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Why is this medication prescribed?

Odevixibat was an experimental drug that was being investigated for the treatment of certain rare liver disorders. Odevixibat belongs to a class of medications known as ileal bile acid transport inhibitors. It is primarily studied for its potential to treat cholestatic liver diseases, such as progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome.

In cholestatic liver diseases, there is a disruption in the flow of bile from the liver, leading to the accumulation of toxic bile acids in the liver and other tissues. Odevixibat works by inhibiting the reabsorption of bile acids in the ileum (the last part of the small intestine), which reduces their concentration in the liver and helps improve liver function.

How should this medicine be used?

The dosing and usage instructions for odevixibat can vary depending on the specific liver disorder being treated, as well as other individual factors. Therefore, it is crucial to consult with a healthcare professional or follow the instructions provided by the prescribing physician.

In clinical trials, odevixibat was typically administered orally in the form of tablets or suspension. The dosing frequency and duration of treatment can differ based on the condition being treated, the patient’s age, weight, and overall health. It is essential to strictly follow the prescribed dosing schedule and any accompanying instructions provided by the healthcare professional.

If you or someone you know is considering the use of odevixibat, it is strongly recommended to consult with a healthcare professional who can provide the most accurate and up-to-date information based on the individual’s specific circumstances and the latest research findings.

Other uses for this medicine

Inquire with your doctor or pharmacist for more details if you believe this drug may be prescribed for other purposes.

What special precautions should I follow?

Here are some general precautions to consider:

  • Consultation with a healthcare professional: Odevixibat is a prescription medication, and it should only be used under the supervision and guidance of a healthcare professional who is familiar with the patient’s medical history and condition.
  • Allergies and sensitivities: Inform your healthcare professional about any known allergies or sensitivities to medications, especially if you have previously experienced any adverse reactions to odevixibat or its ingredients.
  • Pregnancy and breastfeeding: The use of odevixibat during pregnancy or while breastfeeding should be discussed with a healthcare professional. They can weigh the potential benefits against any potential risks to the mother and the developing fetus or nursing infant.
  • Drug interactions: It is important to inform your healthcare professional about all other medications, supplements, or herbal products you are taking. Odevixibat may interact with certain medications, potentially affecting their efficacy or increasing the risk of side effects.
  • Side effects: Like any medication, odevixibat may cause side effects. It is important to be aware of potential side effects and promptly report any unexpected or severe symptoms to your healthcare professional.

These precautions are general in nature, and it is important to consult with a healthcare professional for specific guidance and the most up-to-date information regarding the use of odevixibat, including any additional precautions that may be relevant to your individual circumstances.

What special dietary instructions should I follow?

There were no specific dietary instructions provided for odevixibat. However, it is important to follow a healthy and balanced diet as recommended by your healthcare professional, especially if you have a liver disorder.

What should I do if I forget a dose?

Regarding a missed dose of odevixibat, it is generally advised to take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, it is recommended to skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one.

What side effects can this medication cause?

Here are some of the commonly reported side effects:

  • Diarrhea: Diarrhea was one of the most commonly reported side effects of odevixibat in clinical trials. It may range from mild to severe and can be accompanied by abdominal discomfort or cramping.
  • Abdominal pain: Some individuals may experience abdominal pain or discomfort as a side effect of odevixibat.
  • Vomiting: Nausea and vomiting were reported in some cases, although they were generally mild.
  • Headache: Headaches have been reported as a possible side effect of odevixibat.
  • Elevated liver enzymes: In some instances, odevixibat may cause a temporary increase in liver enzymes in the blood. Regular monitoring of liver function may be necessary during treatment.
  • Changes in blood cholesterol levels: Odevixibat may lead to changes in blood cholesterol levels, including increases in low-density lipoprotein (LDL) cholesterol and decreases in high-density lipoprotein (HDL) cholesterol. Monitoring of lipid levels may be recommended during treatment.
  • Other side effects: Additional side effects that have been reported in clinical trials include upper respiratory tract infection, cough, and fever.

It’s important to note that the above list is not exhaustive, and other side effects may occur. Furthermore, the safety profile of odevixibat may have evolved since my knowledge cutoff. If you are considering the use of odevixibat, it is crucial to consult with a healthcare professional who can provide you with the most up-to-date information on the drug’s side effects and any precautions specific to your individual circumstances.

What should I know about storage and disposal of this medication?


  • Follow the storage instructions provided on the medication packaging or by the pharmacist.
  • Typically, odevixibat is stored at room temperature, away from excessive heat, moisture, and light.
  • Keep the medication out of the reach of children and pets.


  • Dispose of unused or expired odevixibat as instructed by your healthcare professional or pharmacist.
  • Do not flush the medication down the toilet or pour it down the drain unless specifically advised to do so.
  • Follow any local regulations or guidelines for the proper disposal of medications. You can consult your pharmacist or local waste disposal authorities for specific instructions.

In case of emergency/overdose

In case of an emergency or suspected overdose, it is important to seek immediate medical attention. Contact your local emergency services or poison control center. Be prepared to provide them with all relevant information, including the name of the medication (odevixibat), dosage, and any other medications or substances that may have been taken.

What other information should I know?

  • Inform all healthcare professionals involved in your care about all medications you are taking, including odevixibat. This includes prescription medications, over-the-counter drugs, herbal supplements, and vitamins.
  • Attend regular check-ups and follow-up appointments as advised by your healthcare professional to monitor your response to the medication and assess any potential side effects.
  • If you experience any unexpected or concerning symptoms while taking odevixibat, contact your healthcare professional for guidance and advice.

For the most accurate and up-to-date instructions on storage, disposal, emergency procedures, and other relevant information, it is recommended to consult with your healthcare professional and carefully read the information provided with the medication packaging.

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