PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Noxafil (Generic Posaconazole Injection)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!


If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Noxafil (generic name: posaconazole) is an antifungal medication that is prescribed to treat various fungal infections. It belongs to a class of drugs called triazole antifungals. Noxafil is primarily used for the prevention and treatment of invasive fungal infections in individuals with weakened immune systems.

Specifically, Noxafil may be prescribed in the following situations:

  • Prevention of invasive fungal infections: Noxafil can be given as prophylaxis to individuals at high risk of developing fungal infections, such as those undergoing chemotherapy for cancer, recipients of stem cell or organ transplants, and patients with prolonged neutropenia (low white blood cell count).
  • Treatment of invasive aspergillosis: Aspergillosis is a fungal infection caused by the Aspergillus species. Noxafil can be used as a primary or salvage therapy for invasive aspergillosis, which is a serious infection that can affect various organs, particularly in immunocompromised individuals.
  • Treatment of invasive candidiasis: Candidiasis is a fungal infection caused by the Candida species. Invasive candidiasis can occur in individuals with compromised immune systems, such as those with HIV/AIDS or undergoing immunosuppressive therapy. Noxafil may be used to treat invasive candidiasis.
  • Treatment of oropharyngeal candidiasis: Oropharyngeal candidiasis, also known as thrush, is a fungal infection that affects the mouth and throat. Noxafil may be prescribed for the treatment of this condition.

It’s important to note that Noxafil should be used under the supervision of a healthcare professional, as it may have potential side effects and drug interactions. The dosage and duration of treatment will vary depending on the specific condition being treated and the individual’s overall health status.

How should this medicine be used?

Noxafil (posaconazole) is available in intravenous (IV) injection. The specific instructions for using Noxafil may vary depending on the formulation prescribed by your healthcare provider. It is important to carefully follow the instructions provided by your doctor or pharmacist. To be administered intravenously (into a vein), noxafil is sold as a liquid. On the first day, it is often given twice daily, and thereafter once each day, over the course of 30 to 90 minutes. The length of time you must take this medicine will be decided by your doctor. Noxafil is a prescription drug that can be obtained from a hospital or taken home. Your healthcare practitioner will demonstrate how to utilize the medication if you are receiving Noxafil at home. Check to see that you comprehend these instructions, and if not, consult your healthcare professional.

Other uses for this medicine

Noxafil (posaconazole) is primarily prescribed for the prevention and treatment of fungal infections, as mentioned earlier. However, there may be some off-label or investigational uses of Noxafil that are not officially approved by regulatory authorities. Off-label use refers to the use of a medication for a purpose other than its approved indications. It’s important to note that off-label use should only be considered under the guidance and supervision of a healthcare professional.

What special precautions should I follow?

As for special precautions associated with Noxafil use, here are some important points to consider:

  • Allergies: Inform your healthcare provider if you have any known allergies or hypersensitivity to posaconazole or any other antifungal medications. This is important to ensure that Noxafil is safe for you to use.
  • Medication Interactions: Noxafil can interact with other medications, potentially leading to adverse effects or reduced effectiveness. Inform your doctor or pharmacist about all the medications, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements, that you are taking. Pay particular attention to certain medications, such as rifabutin, phenytoin, carbamazepine, and certain statins, as they may interact with Noxafil. These interactions can affect the blood levels of Noxafil or the interacting medication, so dosage adjustments or alternative treatments may be necessary.
  • Pre-existing Medical Conditions: Inform your healthcare provider about any pre-existing medical conditions you have, especially liver problems, kidney problems, or a history of long QT syndrome (a heart rhythm disorder). These conditions may require special monitoring or dosage adjustments while using Noxafil.
  • Pregnancy and Breastfeeding: It is important to discuss the potential risks and benefits of using Noxafil if you are pregnant or planning to become pregnant. The use of Noxafil during pregnancy should be considered only if the potential benefits outweigh the potential risks. Similarly, it is recommended to consult with your healthcare provider regarding the use of Noxafil while breastfeeding, as it may pass into breast milk.
  • Side Effects: Like all medications, Noxafil can cause side effects. Common side effects may include nausea, diarrhea, headache, fever, and rash. If you experience any unusual or severe side effects while using Noxafil, promptly inform your healthcare provider.

It’s crucial to follow your healthcare provider’s instructions and guidance regarding the use of Noxafil. They will consider your specific medical history and individual circumstances to determine the appropriate precautions and dosage adjustments, if needed.

What special dietary instructions should I follow?

When taking Noxafil (posaconazole), there are no specific dietary restrictions that need to be followed. However, it is generally recommended to take Noxafil with food, preferably a full meal, as this can help improve its absorption. Taking it with food can also help reduce the risk of stomach upset or gastrointestinal side effects.

What should I do if I forget a dose?

If you forget to take a dose of Noxafil, try to take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

What side effects can this medication cause?

Noxafil (posaconazole) may cause side effects in some individuals. It’s important to note that not everyone will experience these side effects, and their severity can vary. Some of the common side effects associated with Noxafil include:

  • Gastrointestinal effects: Nausea, vomiting, diarrhea, abdominal pain, and constipation are among the most frequently reported side effects of Noxafil.
  • Headache: Some individuals may experience headaches while taking Noxafil.
  • Elevated liver enzymes: Noxafil can cause an increase in liver enzyme levels, which may be detected through blood tests. It’s important to monitor liver function regularly during treatment.
  • Skin reactions: Rash, itching, and other skin-related reactions have been reported as side effects of Noxafil.
  • Electrolyte disturbances: Noxafil may cause changes in electrolyte levels, such as low potassium or magnesium levels, which can lead to symptoms like muscle weakness, irregular heartbeats, or muscle cramps.
  • QT prolongation: Noxafil has the potential to prolong the QT interval, which is a measure of heart rhythm. Prolongation of the QT interval can increase the risk of arrhythmias, including a serious condition called torsades de pointes.
  • Allergic reactions: In rare cases, allergic reactions to Noxafil can occur. Seek immediate medical attention if you experience signs of a severe allergic reaction, such as difficulty breathing, swelling of the face or throat, or hives.

It’s important to report any side effects to your healthcare provider promptly. They can evaluate the severity of the side effects and provide guidance on whether any adjustments to your treatment plan are necessary.

This is not an exhaustive list of all possible side effects. If you have specific concerns about potential side effects or experience any unusual symptoms while taking Noxafil, it’s best to consult your healthcare provider for personalized advice.

What should I know about storage and disposal of this medication?


  • Keep Noxafil in its original container with the cap tightly closed.
  • Store it at room temperature, away from excessive heat, moisture, and direct light.
  • Do not freeze the oral suspension or tablets.


  • Do not dispose of Noxafil in household trash or flush it down the toilet.
  • Follow any specific disposal instructions provided by your healthcare provider or local guidelines for medication disposal. They may recommend returning unused medication to a pharmacy or using a take-back program.

In case of emergency/overdose

In case of emergency or suspected overdose, immediately contact your local emergency services (such as 911) or your regional poison control center. It’s important to provide them with as much information as possible, including the name of the medication (Noxafil), the strength or dosage form, the amount taken (if known), and the time of the overdose.

What other information should I know?

  • Compliance: It’s essential to take Noxafil as prescribed by your healthcare provider. Follow the recommended dosage, frequency, and duration of treatment. Do not stop taking Noxafil without consulting your healthcare provider, even if you start feeling better. Incomplete treatment can lead to ineffective therapy or recurrence of the fungal infection.
  • Regular Monitoring: Your healthcare provider may monitor your liver function, electrolyte levels, and other relevant parameters during treatment with Noxafil. Attend all scheduled appointments and laboratory tests as advised.
  • Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking. Some medications, including certain antibiotics, antifungals, anticonvulsants, and others, may interact with Noxafil. These interactions can affect the effectiveness or safety of either medication, so it’s important to disclose your complete medication regimen.
  • Allergic Reactions: If you have previously experienced an allergic reaction to Noxafil or any other antifungal medication, inform your healthcare provider. They can assess the risk and provide appropriate guidance.

Always consult your healthcare provider or pharmacist if you have any specific concerns or questions about the storage, disposal, or any other aspects of using Noxafil. They can provide you with the most accurate and up-to-date information based on your individual circumstances.

Copyright © 2023