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NovoLog Mix 70/30 (Generic Insulin Aspart (rDNA Origin) Injection)

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Why is this medication prescribed?

NovoLog Mix 70/30 is a prescription medication used to manage blood sugar levels in individuals with diabetes. It is a combination of two types of insulin: insulin aspart (a rapid-acting insulin) and insulin aspart protamine (an intermediate-acting insulin). The ratio of these insulins in NovoLog Mix 70/30 is 70% insulin aspart and 30% insulin aspart protamine.

NovoLog Mix 70/30 is typically prescribed for people with diabetes who require insulin therapy to control their blood glucose levels. It is primarily used for those with type 2 diabetes, but it may also be used in some cases for individuals with type 1 diabetes.

The main goals of using NovoLog Mix 70/30 are to:

  • Lower Blood Sugar Levels: The insulin in NovoLog Mix 70/30 helps to regulate blood sugar by facilitating the uptake of glucose into cells for energy use, thereby reducing the amount of sugar in the bloodstream.
  • Manage Mealtime Glucose Spikes: The rapid-acting insulin aspart component in the medication starts working quickly after injection to address the rise in blood sugar levels that occur after meals.
  • Provide Basal Insulin Coverage: The intermediate-acting insulin aspart protamine component has a longer duration of action, providing continuous basal insulin coverage between meals and overnight.

By combining these two types of insulin, NovoLog Mix 70/30 offers a convenient option for people who may have difficulty managing their diabetes with separate insulin injections.

How should this medicine be used?

NovoLog Mix 70/30 comes in the form of a subcutaneous injection, which means it is injected under the skin. The dosage and administration schedule will be determined by a healthcare professional based on the individual’s specific needs, blood sugar levels, and other factors.

Here are some general guidelines for using NovoLog Mix 70/30:

  • Dosage: The specific dosage will vary from person to person. It is crucial to follow the healthcare provider’s instructions and not change the dosage without consulting them first.
  • Injection sites: NovoLog Mix 70/30 is typically injected into the subcutaneous tissue of the abdomen, thigh, or upper arm. It’s essential to rotate injection sites to prevent lipodystrophy (changes in fat distribution) and ensure consistent absorption.
  • Timing: The timing of injections will depend on the individual’s meal schedule. NovoLog Mix 70/30 is usually injected 15 minutes before a meal to match the rapid-acting insulin with the meal’s carbohydrate intake.
  • Blood sugar monitoring: Regular blood sugar monitoring is essential while using NovoLog Mix 70/30. This helps to adjust the dosage as needed and maintain optimal blood sugar levels.
  • Storage: NovoLog Mix 70/30 should be stored in the refrigerator. Do not freeze it, and avoid exposing it to direct sunlight or high temperatures. Once opened, it can be kept at room temperature for up to 14 days.

Remember, insulin therapy requires careful management, and it is essential to work closely with a healthcare professional to determine the correct dosage and administration schedule for NovoLog Mix 70/30. Additionally, any changes in diet, exercise, or other medications should be discussed with the healthcare provider as they can affect blood sugar levels and insulin requirements.

Other uses for this medicine

NovoLog Mix 70/30 is primarily indicated for the treatment of diabetes mellitus, as explained in the previous response. However, it is important to note that medications like NovoLog Mix 70/30 should only be used for their approved indications and as prescribed by a healthcare professional. Using it for other purposes not listed in the official prescribing information is considered off-label use and should be avoided without proper medical guidance.

What special precautions should I follow?

Special precautions for using NovoLog Mix 70/30:

  • Allergies: Inform your healthcare provider if you are allergic to insulin aspart or any other ingredients in NovoLog Mix 70/30. Allergic reactions to insulin can occur and may cause symptoms like rash, itching, difficulty breathing, or swelling of the face, tongue, or throat.
  • Hypoglycemia (low blood sugar): NovoLog Mix 70/30 can cause hypoglycemia if the dose is too high or if you skip meals, exercise excessively, or consume alcohol. Learn to recognize the symptoms of hypoglycemia, such as sweating, dizziness, rapid heartbeat, confusion, and weakness. Carry a fast-acting source of glucose (like glucose tablets or gel) at all times to treat low blood sugar episodes.
  • Hyperglycemia (high blood sugar): Monitor your blood sugar regularly to ensure it stays within the target range. High blood sugar levels can lead to hyperglycemia, which can cause symptoms like increased thirst, frequent urination, blurred vision, and fatigue.
  • Changes in insulin needs: The dosage of NovoLog Mix 70/30 may need to be adjusted during times of illness, stress, changes in physical activity, or changes in diet. Always consult your healthcare provider before making any adjustments to your insulin regimen.
  • Drug interactions: Certain medications can affect insulin requirements, so inform your healthcare provider about all the medications, including over-the-counter drugs and supplements, you are taking.
  • Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of NovoLog Mix 70/30 with your healthcare provider. Proper management of blood sugar levels is essential during pregnancy, and insulin requirements may change during this time.
  • Medical conditions: Inform your healthcare provider about any other medical conditions you have, such as kidney or liver problems, as they can impact the use of NovoLog Mix 70/30.
  • Storage: Follow the storage instructions provided with the medication. Do not use NovoLog Mix 70/30 if it has been frozen or exposed to extreme heat.

Always follow your healthcare provider’s instructions and attend regular check-ups to monitor your diabetes management and adjust your insulin regimen as needed. Properly managing your diabetes can help reduce the risk of complications and improve your overall health.

What special dietary instructions should I follow?

Special Dietary Instructions for NovoLog Mix 70/30:

  • Your doctor or a registered dietitian will likely provide specific dietary guidelines to manage your diabetes while using NovoLog Mix 70/30.
  • Typically, people taking insulin need to monitor their carbohydrate intake and distribute it evenly throughout the day. This helps match the insulin action to the food being consumed, thus controlling blood sugar levels.
  • It’s essential to eat balanced meals and avoid excessive intake of sugary or high-carbohydrate foods and beverages.
  • Incorporate a variety of nutrient-rich foods, such as vegetables, lean proteins, whole grains, and healthy fats into your diet.

What should I do if I forget a dose?

If you forget to take a dose of NovoLog Mix 70/30, follow these general guidelines:

  • If you forget to take a dose of NovoLog Mix 70/30 at your usual time, take it as soon as you remember, but make sure there is a sufficient time gap until your next scheduled dose. Do not take a double dose to make up for a missed one.
  • If you are unsure about what to do or if you miss doses frequently, contact your healthcare provider for guidance.

What side effects can this medication cause?

NovoLog Mix 70/30, like any medication, may cause side effects in some individuals. Not everyone will experience side effects, and the severity and frequency of side effects can vary from person to person. Common side effects of NovoLog Mix 70/30 may include:

  • Hypoglycemia: Low blood sugar (hypoglycemia) is a potential side effect of all insulin medications, including NovoLog Mix 70/30. Symptoms of hypoglycemia can include sweating, dizziness, rapid heartbeat, trembling, confusion, irritability, and weakness. It is essential to monitor blood sugar levels regularly and be prepared to treat hypoglycemia with a fast-acting source of glucose, such as glucose tablets or gel.
  • Injection Site Reactions: Some individuals may experience redness, swelling, itching, or pain at the injection site. These reactions are usually mild and go away on their own.
  • Allergic Reactions: While rare, some people may experience allergic reactions to NovoLog Mix 70/30. Symptoms of an allergic reaction can include rash, itching, difficulty breathing, swelling of the face, tongue, or throat. If you experience any signs of an allergic reaction, seek immediate medical attention.
  • Hypokalemia: In some cases, insulin therapy can cause low potassium levels in the blood (hypokalemia). This can lead to symptoms like muscle weakness, cramps, and an irregular heartbeat.
  • Weight Gain: Insulin therapy, including NovoLog Mix 70/30, may be associated with weight gain in some individuals.
  • Edema: Fluid retention and edema (swelling) may occur with insulin therapy, though it is not very common.
  • Lipodystrophy: Repeated injections at the same site can cause fat tissue breakdown or buildup, leading to lumps or indentations in the skin known as lipodystrophy.

It’s important to remember that the benefits of insulin therapy in managing diabetes usually outweigh the potential side effects. Most people who use NovoLog Mix 70/30 do not experience serious side effects. However, if you notice any unusual or concerning symptoms while using this medication, it’s essential to inform your healthcare provider promptly. They can help assess the situation and make any necessary adjustments to your treatment plan.

This list of side effects is not exhaustive, and other rare or uncommon side effects may occur. Always consult your healthcare provider or diabetes educator for more comprehensive information about potential side effects associated with NovoLog Mix 70/30 and any other medications you may be taking.

What should I know about storage and disposal of this medication?


  • NovoLog Mix 70/30 should be stored in the refrigerator at a temperature between 36°F and 46°F (2°C to 8°C).
  • Do not freeze NovoLog Mix 70/30. Freezing can damage the insulin and make it ineffective.
  • If necessary, unopened vials or pen cartridges can be kept at room temperature (up to 86°F or 30°C) for up to 14 days. Keep them away from direct sunlight and heat sources.
  • Once a vial or pen cartridge is in use, it can be stored at room temperature (up to 86°F or 30°C) for up to 14 days. However, avoid exposing it to extreme heat or sunlight.


  • Safely dispose of used needles and syringes in a sharps container or a puncture-proof container, such as a heavy-duty plastic container with a secure lid.
  • Do not throw away NovoLog Mix 70/30 or any other medications in the household trash or flush them down the toilet unless specifically instructed to do so by local guidelines or authorities.

In case of emergency/overdose

If you suspect an overdose of NovoLog Mix 70/30 or experience severe hypoglycemia (low blood sugar) symptoms, seek immediate medical attention or contact your local emergency services.

Symptoms of hypoglycemia (low blood sugar) may include:

  • Sweating
  • Dizziness
  • Rapid or irregular heartbeat
  • Shakiness or trembling
  • Blurred vision
  • Extreme hunger
  • Confusion or irritability
  • Weakness or fatigue

What other information should I know

  • Keep a fast-acting source of glucose with you at all times, such as glucose tablets or gel, to treat episodes of hypoglycemia.
  • Regularly monitor your blood sugar levels as directed by your healthcare provider to ensure they stay within the target range.
  • Always follow your healthcare provider’s instructions regarding insulin dosing, meal planning, and exercise to effectively manage your diabetes.
  • Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, you are taking, as they may interact with NovoLog Mix 70/30.
  • Attend regular check-ups with your healthcare provider to review your diabetes management plan and make any necessary adjustments to your insulin regimen.
  • Inform medical personnel about your use of NovoLog Mix 70/30 in case of any medical procedures or hospitalizations.

Remember, diabetes management requires careful attention to your insulin regimen, diet, and lifestyle. Always consult your healthcare provider or diabetes educator if you have any questions or concerns about using NovoLog Mix 70/30 or managing your diabetes effectively.

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