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Nourianz (Generic Istradefylline)

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Why is this medication prescribed?

Nourianz (generic name: istradefylline) is a medication that was prescribed as an adjunctive (additional) treatment for Parkinson’s disease. Parkinson’s disease is a neurodegenerative disorder that affects movement and is characterized by symptoms such as tremors, stiffness, and difficulty with balance and coordination.

Nourianz is specifically indicated for use in patients with Parkinson’s disease who experience “off” episodes, which are periods when their medications are not working optimally, leading to a return of symptoms. It works by blocking a specific receptor in the brain called adenosine A2A, which helps to restore normal movement by modulating the activity of neurotransmitters involved in motor function.

How should this medicine be used?

Nourianz (istradefylline) is available in tablet form and should be taken orally. The specific dosing instructions for Nourianz may vary depending on the individual and their condition, so it’s important to follow the instructions provided by the prescribing healthcare professional. Here are some general guidelines:

  • Nourianz is usually taken once daily, with or without food. It is important to take it at the same time each day to maintain a consistent level of the medication in your body.
  • The starting dose of Nourianz is typically 20 mg per day. However, your doctor may adjust the dose based on your individual response and tolerance.
  • Swallow the tablet whole with a glass of water. Do not crush, break, or chew the tablet unless specifically instructed by your doctor.
  • It may take several weeks to experience the full benefits of Nourianz. Continue taking it regularly as prescribed, even if you start feeling better.
  • If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
  • It’s important to follow up with your healthcare professional regularly to monitor your response to Nourianz and make any necessary adjustments to your treatment plan.

Remember, these are general guidelines, and individual dosing and instructions may vary. Always follow the specific instructions provided by your healthcare professional. If you have any questions or concerns about your medication regimen, it’s best to consult with your prescribing doctor or pharmacist.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you think this drug may be recommended for other conditions.

What special precautions should I follow?

Nourianz (generic name: istradefylline) is a medication used in the treatment of Parkinson’s disease. When taking Nourianz, it is important to follow certain precautions to ensure its safe and effective use. Here are some special precautions associated with Nourianz:

  • Allergies: Inform your healthcare provider if you have any known allergies to istradefylline or any other medications. They can assess whether Nourianz is suitable for you or if an alternative medication should be considered.
  • Medical conditions: Discuss your medical history with your doctor, especially if you have a history of cardiovascular disease, abnormal heart rhythms, liver problems, or any other significant health conditions. Certain medical conditions may require caution or monitoring while taking Nourianz.
  • Interactions: Inform your doctor about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and supplements. Nourianz may interact with certain medications, such as monoamine oxidase inhibitors (MAOIs), which can lead to potentially serious side effects.
  • Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using Nourianz with your healthcare provider. The safety of Nourianz during pregnancy and breastfeeding has not been established, so a thorough evaluation is necessary.
  • Driving and operating machinery: Nourianz may cause dizziness, drowsiness, or other neurological side effects that can impair your ability to drive or operate machinery. It is important to assess your individual response to the medication and avoid potentially dangerous activities until you are certain of how Nourianz affects you.
  • Alcohol: Avoid or limit the consumption of alcohol while taking Nourianz. Alcohol can exacerbate the sedative effects of the medication and may increase the risk of side effects.
  • Regular check-ups: Follow up with your healthcare provider regularly to monitor your response to Nourianz and to evaluate its effectiveness. Your doctor may need to adjust the dose or make other treatment modifications based on your progress.

Always consult your healthcare provider for personalized advice and guidance regarding the precautions specific to your situation when taking Nourianz or any other medication.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Nourianz. However, it is generally recommended to follow a balanced and healthy diet when taking any medication. Consider the following guidelines:

  • Balanced diet: Consume a variety of foods from different food groups, including fruits, vegetables, whole grains, lean proteins, and healthy fats.
  • Adequate hydration: Drink sufficient water throughout the day to stay hydrated.
  • Levodopa interactions: If you are also taking levodopa, be mindful of the timing of your meals. High-protein meals or protein supplements can interfere with the absorption of levodopa. Consult your healthcare provider for specific instructions on the timing of medication and dietary protein.

What should I do if I forget a dose?

If you forget to take a dose of Nourianz, follow these steps:

  • Take it as soon as you remember: If you remember within a few hours of the missed dose, take it immediately.
  • Skip the missed dose if too close to the next dose: If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
  • Consult your doctor or pharmacist: If you are unsure about what to do or have concerns about missed doses, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Nourianz (istradefylline) is a medication used in the treatment of Parkinson’s disease. Like any medication, it can cause certain side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience them to a greater or lesser extent. If you have any concerns about the side effects of Nourianz, it is best to consult your healthcare provider. Here are some potential side effects associated with Nourianz:

  • Dyskinesia: Nourianz may increase the risk of developing or worsening dyskinesia, which refers to involuntary or abnormal movements. This is particularly important to monitor if Nourianz is used in conjunction with levodopa.
  • Dizziness: Some individuals may experience dizziness or lightheadedness while taking Nourianz. It is advisable to avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you.
  • Hallucinations: Nourianz may cause hallucinations or other psychotic-like behavior. If you experience any unusual changes in perception or behavior, it is important to inform your healthcare provider.
  • Insomnia: Difficulty sleeping or insomnia may occur in some individuals taking Nourianz. If you experience sleep disturbances, it is recommended to discuss this with your doctor.
  • Nausea: Nourianz can cause nausea or an upset stomach. Taking the medication with food may help reduce these symptoms.
  • Orthostatic hypotension: Some individuals may experience a drop in blood pressure upon standing, resulting in dizziness or lightheadedness. It is important to rise slowly from a sitting or lying position to minimize the risk of falls.
  • Other common side effects: Additional side effects that may occur include constipation, headache, dry mouth, decreased appetite, abnormal dreams, and fatigue.

It’s important to promptly report any unusual or severe side effects to your healthcare provider. They can provide guidance, adjust the dosage if necessary, or suggest alternative treatment options.

What should I know about storage and disposal of this medication?

  • Storage: Keep Nourianz in its original container, tightly closed, and out of reach of children and pets. Store it at room temperature, away from excessive heat, moisture, and direct sunlight. Avoid storing it in the bathroom, as the humidity can affect its stability.
  • Disposal: Do not dispose of Nourianz in household trash or flush it down the toilet unless instructed to do so. Properly dispose of unused or expired medication through medication take-back programs or follow the guidelines provided by your local pharmacy or healthcare facility.

In case of emergency/overdose

  • If you or someone else is experiencing severe symptoms or has taken an excessive amount of Nourianz, immediately call emergency services or go to the nearest emergency room.
  • You can also contact your local poison control center for guidance on how to handle the situation.

What other information should I know?

Additionally, inform your doctor about any allergies or hypersensitivities you may have, as well as any previous adverse reactions to medications. They can assess the appropriateness of prescribing Nourianz based on your individual circumstances.

Lastly, attend regular follow-up appointments with your doctor to monitor the medication’s effectiveness and address any concerns or questions you may have.

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