PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Nefrecil (Generic Phenazopyridine)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!


If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Phenazopyridine is a medication prescribed to provide relief from the discomfort, pain, and burning sensation that can occur during urinary tract infections (UTIs) and other urinary tract irritations. It is a urinary analgesic that helps to soothe the lining of the urinary tract, particularly the bladder, by acting as a local anesthetic. It does not treat the underlying cause of the infection or irritation but can provide symptomatic relief while other treatments, such as antibiotics, work to address the infection itself.

How should this medicine be used?

Phenazopyridine is typically used to provide relief from discomfort, pain, and burning sensation that can occur during urinary tract infections (UTIs) and other urinary tract irritations. It is important to use Phenazopyridine as directed by your healthcare provider. Here are some general guidelines for its use:

  • Dosage: The typical adult dosage of Phenazopyridine is 200 mg to 300 mg, taken orally three times a day after meals. The exact dosage may vary depending on the severity of symptoms and the specific prescription provided by your healthcare provider.
  • Short-term use: Phenazopyridine is intended for short-term use only, usually for no more than two days. If your symptoms persist beyond this period, or if they worsen, seek further medical evaluation, as it may indicate an unresolved or worsening condition that requires different treatment.
  • Water intake: While taking Phenazopyridine, it is essential to drink plenty of water to help flush out bacteria and reduce the concentration of urine. Adequate hydration is crucial for maintaining a healthy urinary tract.
  • Full course: Complete the entire course of Phenazopyridine as prescribed by your healthcare provider, even if you start feeling better. Stopping the medication prematurely may lead to incomplete symptom relief and potential recurrence of the infection.
  • Avoid long-term use: Phenazopyridine is not meant for prolonged use. If your symptoms persist for more than two days, or if they recur, consult your healthcare provider for further evaluation and appropriate treatment.
  • Staining of urine: Phenazopyridine can temporarily cause your urine to become reddish-orange or brown in color. This is normal and should not be a cause for concern. However, be cautious, as it may stain clothing.
  • Symptomatic relief: Remember that Phenazopyridine is not an antibiotic and does not treat the underlying infection causing the symptoms. It provides symptomatic relief by soothing the urinary tract lining and reducing pain and discomfort.
  • Follow-up: Attend any follow-up appointments as scheduled by your healthcare provider. They may want to monitor your progress and ensure that the infection or condition is resolving appropriately.
  • Inform your healthcare provider: Before starting Phenazopyridine, inform your healthcare provider about any allergies, medical conditions, or medications you are taking, to avoid potential interactions or contraindications.

Always follow your healthcare provider’s instructions and the instructions on the medication label carefully. If you have any questions or concerns about the use of Phenazopyridine, do not hesitate to contact your healthcare provider for guidance.

Other uses for this medicine

Phenazopyridine is primarily used for providing symptomatic relief from urinary tract infections (UTIs) and urinary tract irritations. However, it may also be used off-label for other purposes, as determined by a healthcare provider. Some examples of off-label uses may include temporary relief from discomfort or pain in certain urological conditions or after certain medical procedures involving the urinary tract. Nonetheless, it’s essential to emphasize that using Phenazopyridine for off-label purposes should be done under the guidance and supervision of a healthcare professional.

What special precautions should I follow?

  • Allergies: If you have a known allergy to Phenazopyridine or any of its ingredients, you should avoid using this medication.
  • Liver or kidney problems: Individuals with liver or kidney disease should use Phenazopyridine with caution and under the supervision of a healthcare provider, as the drug is metabolized in the liver and excreted by the kidneys. Dosing adjustments may be necessary in such cases.
  • Pregnancy and breastfeeding: Phenazopyridine is not recommended during pregnancy or while breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for safer alternatives.
  • Pediatric use: Phenazopyridine is generally not recommended for children under the age of 12 unless specifically prescribed by a pediatrician.
  • Elderly population: Elderly individuals may be more susceptible to certain side effects of Phenazopyridine. Caution should be exercised, and dosage adjustments may be necessary.
  • Interactions with other medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Phenazopyridine can interact with certain drugs, potentially affecting their effectiveness or increasing the risk of side effects.
  • Blood glucose testing: Phenazopyridine can interfere with urine tests for glucose, giving false-positive results. If you need to test your urine for glucose, inform the healthcare provider that you are taking Phenazopyridine.
  • Eye discoloration: Prolonged use of Phenazopyridine may lead to a yellowish discoloration of the sclera (the white part of the eye). This effect is harmless and reversible upon discontinuation of the medication.
  • Avoid long-term use: Phenazopyridine is not meant for prolonged use. If your symptoms persist for more than two days, or if they worsen, seek further medical evaluation.
  • Alcohol consumption: Avoid consuming alcohol while taking Phenazopyridine, as it may increase the risk of liver toxicity.

Always follow the specific instructions provided by your healthcare provider, and do not hesitate to seek their advice if you have any concerns or experience adverse effects while using Phenazopyridine.

What special dietary instructions should I follow?

  • There are no specific dietary restrictions associated with Phenazopyridine. However, it’s generally a good practice to take the medication with food to minimize potential stomach upset.
  • Drinking plenty of water while taking Phenazopyridine can help flush out your urinary system and may aid in reducing symptoms.

What should I do if I forget a dose?

  • If you miss a dose of Phenazopyridine, take it as soon as you remember. However, if it is close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
  • Never take a double dose to make up for a missed one, as this can increase the risk of side effects.

What side effects can this medication cause?

As for the side effects of Phenazopyridine, it is a medication commonly used to relieve urinary pain, burning, and discomfort associated with urinary tract infections or other urinary conditions. Some possible side effects may include:

Common side effects:

  • Headache
  • Dizziness
  • Stomach upset or nausea
  • Vomiting
  • Upset stomach
  • Diarrhea
  • Itching or skin rash
  • Reddish or orange discoloration of urine (this is normal and expected while taking Phenazopyridine)

Less common side effects:

  • Methemoglobinemia: This is a rare condition where the drug causes an abnormal increase in methemoglobin, a form of hemoglobin that cannot carry oxygen effectively. Symptoms include bluish lips or fingernails, shortness of breath, fatigue, confusion, and rapid heart rate. Seek medical attention immediately if you experience any of these symptoms.

Phenazopyridine may also cause allergic reactions in some individuals, which can be severe and require immediate medical attention. Signs of an allergic reaction may include difficulty breathing, hives, swelling of the face, lips, tongue, or throat.

Keep in mind that this is not an exhaustive list of side effects, and individual responses to medications can vary. If you experience any unusual or severe side effects while taking Phenazopyridine, contact your healthcare provider promptly. They can provide personalized advice and recommendations based on your specific medical history and condition.

What should I know about storage and disposal of this medication?

  • Storage: Keep Phenazopyridine in its original container, tightly closed, and at room temperature (usually between 68°F to 77°F or 20°C to 25°C). Protect it from light, moisture, and excessive heat.
  • Keep out of reach of children and pets: Store Phenazopyridine in a safe place where children and pets cannot access it.
  • Disposal: If you have any leftover or expired Phenazopyridine, do not flush it down the toilet or pour it down the drain unless specifically instructed to do so. Properly dispose of unused medication according to local guidelines and regulations. You can consult your pharmacist or local waste disposal facility for guidance on how to dispose of medications safely.

In case of emergency/overdose

  • If you suspect an overdose or accidental ingestion of a large amount of Phenazopyridine, call your local emergency number (such as 911 in the United States) or go to the nearest emergency room immediately.
  • Symptoms of overdose may include severe dizziness, severe headache, rapid heartbeat, nausea, vomiting, and difficulty breathing. Be prepared to provide information about the medication and the amount taken.

What other information should I know?

  • Follow medical advice: Always take Phenazopyridine as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting them first.
  • Inform healthcare provider: Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Phenazopyridine, to avoid potential drug interactions.
  • Follow up: Attend all follow-up appointments as scheduled by your healthcare provider. This is important to monitor your progress and address any concerns or side effects.
  • Urine discoloration: Phenazopyridine can cause a temporary reddish-orange or brown discoloration of the urine. This effect is harmless but may stain clothing, so be cautious.
  • Medical conditions: Inform your healthcare provider about any existing medical conditions, especially liver or kidney problems, before using Phenazopyridine.
  • Allergic reactions: If you experience symptoms of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.
  • Avoid alcohol and driving: Phenazopyridine may cause drowsiness and impair your ability to drive or operate machinery. Avoid consuming alcohol while taking this medication.
  • Short-term use: Phenazopyridine is meant for short-term use only. If your symptoms persist beyond the recommended duration, contact your healthcare provider for further evaluation and treatment.

Always adhere to the guidance provided by your healthcare provider and the instructions on the medication label for safe and effective use of Phenazopyridine. If you have any questions or concerns, don’t hesitate to reach out to your healthcare professional for clarification.

Copyright © 2023