PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Naprelan (Generic Naproxen)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Naprelan is an extended-release form of naproxen, a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and swelling. While Naprelan can be effective for many individuals, it is important to be aware of the potential risks associated with its use. Here are some key risks:

  • Gastrointestinal Effects: Like other NSAIDs, Naprelan can cause stomach irritation, ulcers, and gastrointestinal bleeding. This risk is higher in individuals who are older, have a history of stomach ulcers or bleeding, or take high doses of Naprelan for an extended period.
  • Cardiovascular Risks: NSAIDs, including Naprelan, may increase the risk of heart attack, stroke, and other cardiovascular events, particularly when used in high doses or for long durations. This risk is more significant in individuals with existing heart conditions or those who have a high risk of developing cardiovascular problems.
  • Kidney Problems: Prolonged use of Naprelan can lead to kidney damage, including the risk of kidney failure. Individuals with pre-existing kidney issues or dehydration are at a higher risk.
  • Allergic Reactions: Some individuals may experience allergic reactions to Naprelan, including hives, rash, swelling, or difficulty breathing. It is essential to seek immediate medical attention if any signs of an allergic reaction occur.
  • Other Side Effects: Common side effects of Naprelan may include dizziness, headache, stomach upset, indigestion, and mild gastrointestinal discomfort.

It’s crucial to consult with a healthcare professional before starting Naprelan or any medication. They can evaluate your specific health condition, consider potential risks, and determine if Naprelan is suitable for you. Additionally, following the prescribed dosage and duration, and promptly reporting any concerning symptoms to your healthcare provider can help mitigate risks.

Why is this medication prescribed?

Naprelan is a prescription medication that contains the active ingredient naproxen sodium. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naprelan is primarily prescribed to relieve pain and reduce inflammation in conditions such as:

  • Osteoarthritis: It is a degenerative joint disease characterized by the breakdown of cartilage and inflammation in the joints. Naprelan helps alleviate pain and stiffness associated with osteoarthritis.
  • Rheumatoid arthritis: This is an autoimmune disorder where the immune system mistakenly attacks the joints, causing inflammation and pain. Naprelan can help reduce the inflammation and manage the symptoms of rheumatoid arthritis.
  • Ankylosing spondylitis: It is a type of inflammatory arthritis that primarily affects the spine and can lead to stiffness and pain. Naprelan is sometimes prescribed to manage the symptoms of ankylosing spondylitis.
  • Juvenile arthritis: This refers to arthritis that occurs in children. Naprelan may be prescribed to help relieve pain and inflammation in children with juvenile arthritis.
  • Tendonitis and bursitis: These conditions involve inflammation of tendons (tendonitis) or bursae (small fluid-filled sacs that cushion the joints, bursitis). Naprelan can be used to reduce pain and inflammation in these conditions.

It’s important to note that Naprelan, like other NSAIDs, can have potential side effects and interactions with other medications. Therefore, it should only be taken under the supervision and prescription of a healthcare professional who can determine the appropriate dosage and duration of treatment based on an individual’s specific condition and medical history.

How should this medicine be used?

Naprelan should be used exactly as prescribed by your healthcare provider. It is important to follow the instructions on the prescription label and consult your doctor or pharmacist if you have any questions or concerns. Here are some general guidelines for using Naprelan:

  • Dosage: The dosage of Naprelan will vary depending on the condition being treated, the severity of symptoms, and individual factors. Your doctor will determine the appropriate dosage for you. It is important to stick to the prescribed dosage and not exceed it without your doctor’s approval.
  • Timing: Naprelan is usually taken once daily. It is designed to provide a prolonged release of the medication over time, offering 24-hour pain relief. It is typically taken with food to help reduce the risk of stomach upset.
  • Swallowing: Naprelan tablets should be swallowed whole with a glass of water. Do not crush, chew, or break the tablets, as this can interfere with the delayed-release mechanism.
  • Duration: The duration of Naprelan treatment will depend on the specific condition being treated and its response to the medication. Follow your doctor’s instructions regarding the duration of treatment. It is generally not recommended to use Naprelan for an extended period without medical supervision.
  • Interactions: Inform your doctor about all the medications you are currently taking, including over-the-counter drugs, supplements, and herbal products. Some medications may interact with Naprelan and affect its effectiveness or increase the risk of side effects.

Remember, this information is a general guideline, and it is essential to consult your healthcare provider for personalized advice and instructions regarding the use of Naprelan.

Other uses for this medicine

Naprelan is primarily prescribed for pain relief and reducing inflammation in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, and bursitis, as mentioned earlier. However, there may be other off-label uses for Naprelan that are not mentioned in the prescribing information. Off-label use refers to the use of a medication for a purpose other than its approved indications. If your doctor prescribes Naprelan for a different condition, they will have assessed the potential benefits and risks based on their clinical judgment.

What special precautions should I follow?

As for special precautions associated with Naprelan use, it’s important to consider the following:

  • Allergies: If you have a known allergy or hypersensitivity to naproxen sodium or any other NSAIDs, inform your doctor. Allergic reactions can range from mild skin rashes to severe symptoms like difficulty breathing, so it’s crucial to avoid Naprelan if you have a known allergy.
  • Gastrointestinal effects: NSAIDs, including Naprelan, can increase the risk of stomach ulcers, bleeding, and perforation, which can be life-threatening. This risk is higher in elderly individuals, those with a history of stomach ulcers or gastrointestinal bleeding, and those taking high doses or long-term treatment. To minimize these risks, Naprelan should be used at the lowest effective dose for the shortest duration necessary.
  • Cardiovascular effects: NSAIDs may increase the risk of heart attack, stroke, and other cardiovascular events, especially when used long-term or in high doses. This risk may be higher in individuals with pre-existing cardiovascular conditions or risk factors. It’s essential to discuss your medical history with your doctor, especially if you have heart disease, high blood pressure, or a history of stroke.
  • Kidney effects: Naprelan can potentially cause kidney problems, including kidney injury or worsening of pre-existing kidney disease. If you have kidney problems or are at risk for kidney disease, your doctor may need to monitor your kidney function regularly while you are taking Naprelan.
  • Pregnancy and breastfeeding: Naprelan is generally not recommended during pregnancy, especially in the later stages, as it may harm the unborn baby or cause complications during delivery. It may also pass into breast milk, so it’s important to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Drug interactions: Naprelan can interact with other medications, including but not limited to blood thinners, other NSAIDs, diuretics, and certain antidepressants. These interactions can affect the effectiveness of either medication or increase the risk of side effects. Inform your doctor about all the medications you are taking to ensure they are aware of any potential interactions.

It’s crucial to discuss your medical history, current medications, and any specific concerns with your healthcare provider before starting Naprelan to ensure its safe and appropriate use for your individual circumstances.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Naprelan use. However, taking Naprelan with food or milk can help reduce the risk of stomach upset. If you experience any gastrointestinal discomfort while taking Naprelan, it may be helpful to avoid spicy, fatty, or acidic foods, as they can exacerbate stomach issues. It’s always a good idea to maintain a balanced and healthy diet while taking any medication.

What should I do if I forget a dose?

If you forget to take a dose of Naprelan, follow these general guidelines:

  • Regular Dosage: If you usually take Naprelan once daily and miss a dose, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
  • Extended-release Dosage: Naprelan is designed to provide a prolonged release of the medication over time. If you miss a dose of an extended-release formulation, contact your healthcare provider for specific instructions. It’s important not to crush, chew, or break the tablets to ensure the proper release of the medication.

What side effects can this medication cause?

Naprelan, like other nonsteroidal anti-inflammatory drugs (NSAIDs), can cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. Common side effects of Naprelan may include:

  • Gastrointestinal effects: Naprelan can irritate the lining of the stomach and intestines, leading to gastrointestinal side effects such as indigestion, heartburn, stomach pain, nausea, vomiting, and diarrhea. In some cases, it can also cause stomach ulcers or gastrointestinal bleeding, which can be serious.
  • Cardiovascular effects: NSAIDs, including Naprelan, have been associated with an increased risk of cardiovascular events such as heart attack and stroke, particularly when used at high doses or for long periods. This risk may be higher in individuals with pre-existing cardiovascular conditions or risk factors.
  • Fluid retention and edema: Naprelan may cause fluid retention, leading to swelling in the hands, ankles, or feet.
  • Kidney effects: NSAIDs, including Naprelan, can affect kidney function, especially in individuals with pre-existing kidney problems or those at risk for kidney disease. It may cause fluid and electrolyte imbalances or worsen existing kidney conditions.
  • Headache, dizziness, and drowsiness: These side effects may occur, although they are generally mild and temporary.
  • Allergic reactions: Although rare, allergic reactions to Naprelan can occur. Symptoms may include skin rashes, hives, itching, swelling, difficulty breathing, or wheezing. Allergic reactions require immediate medical attention.

Additionally, long-term and high-dose use of Naprelan or other NSAIDs may increase the risk of experiencing side effects. To minimize the risk, it is recommended to use the lowest effective dose for the shortest duration necessary under the guidance of a healthcare professional.

Always consult your doctor or pharmacist if you have any concerns about the side effects of Naprelan or if you experience any unexpected or severe symptoms while taking the medication.

What should I know about storage and disposal of this medication?


  • Follow the storage instructions provided by your pharmacist or the medication packaging. Typically, Naprelan should be stored at room temperature (between 68°F and 77°F or 20°C and 25°C).
  • Keep Naprelan away from moisture, heat, and direct sunlight.
  • Store the medication in its original container, tightly closed, and out of reach of children and pets.


  • Do not keep outdated or unused Naprelan tablets. Properly dispose of them to prevent accidental ingestion or misuse.
  • Follow local regulations and guidelines for the disposal of medication. Check with your pharmacist or local waste disposal facility for proper disposal methods.

In case of emergency/overdose

  • Contact emergency medical services or your local poison control center immediately (e.g., call the National Poison Control Center at 1-800-222-1222 in the United States).
  • Provide them with information about the medication, including the name (Naprelan), strength, and the amount ingested (if known).
  • If possible, have the medication container or packaging available for reference.
  • Follow the instructions provided by the medical professionals or poison control center.

What other information should I know?

  • Regular check-ups: It’s important to have regular check-ups with your healthcare provider while taking Naprelan to monitor your response to the medication, evaluate any side effects, and adjust the treatment plan if necessary.
  • Interaction with other medications: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, supplements, and herbal products. Certain medications may interact with Naprelan and alter its effectiveness or increase the risk of side effects.
  • Allergy and medical history: Inform your doctor about any known allergies or hypersensitivity to NSAIDs or any other medications. Also, provide a comprehensive medical history, including any previous stomach ulcers, gastrointestinal bleeding, heart problems, high blood pressure, kidney disease, or liver disease.
  • Avoid alcohol: Consumption of alcohol while taking Naprelan may increase the risk of stomach bleeding and other adverse effects. It’s generally recommended to limit or avoid alcohol during NSAID treatment.
  • Follow-up appointments: Attend follow-up appointments with your healthcare provider as scheduled to monitor your progress and ensure the continued appropriateness of Naprelan for your condition.

Remember, this information is not exhaustive, and it is crucial to consult your healthcare provider or pharmacist for specific guidance and any additional information related to the use, storage, disposal, and potential emergencies associated with Naprelan.

Copyright © 2023