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Milprem (Generic Meprobamate)

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Why is this medication prescribed?

Meprobamate is prescribed primarily for its anxiolytic (anxiety-reducing) and muscle-relaxant properties. It is used in the short-term treatment of anxiety and tension-related disorders, as well as to alleviate muscle spasms and tension. Here are some common reasons why healthcare providers may prescribe Meprobamate:

  • Anxiety Disorders: Meprobamate can help relieve symptoms of anxiety disorders, such as generalized anxiety disorder (GAD), when used for short-term relief. It is not typically recommended for long-term use due to the risk of dependence and tolerance.
  • Muscle Spasms: Meprobamate’s muscle-relaxant properties make it useful in the treatment of conditions involving muscle spasms, such as back pain, neck pain, and certain musculoskeletal injuries.
  • Preoperative Anxiety: In some cases, Meprobamate may be prescribed before surgery to help patients relax and reduce anxiety before a surgical procedure.

It’s important to note that Meprobamate is generally intended for short-term use, typically no longer than a few weeks. Prolonged use can lead to dependence, tolerance, and withdrawal symptoms when the medication is discontinued. Because of these risks, healthcare providers usually explore other treatment options for long-term anxiety management, such as therapy and other medications with a lower potential for dependence.

How should this medicine be used?

Here are some general guidelines for using Meprobamate:

  • Dosage: The typical adult dosage for Meprobamate ranges from 200 mg to 400 mg, divided into two to four doses per day. However, your healthcare provider will determine the appropriate dosage based on your condition and individual response to the medication.
  • Take as Prescribed: Always take Meprobamate exactly as prescribed by your healthcare provider. Do not take more or less of the medication, and do not alter the dosing schedule without consulting your doctor.
  • With or Without Food: Meprobamate can be taken with or without food. If it upsets your stomach, taking it with food or milk may help alleviate any gastrointestinal discomfort.
  • Duration: Meprobamate is generally prescribed for short-term use, usually no longer than a few weeks. Prolonged use can lead to dependence and tolerance, so it should not be used for extended periods unless specifically directed by your healthcare provider.
  • Do Not Suddenly Stop: If your healthcare provider decides to discontinue Meprobamate or switch you to another medication, they will provide guidance on how to gradually reduce the dosage to prevent withdrawal symptoms. Do not abruptly stop taking Meprobamate without consulting your doctor.
  • Missed Doses: If you forget to take a dose, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.
  • Alcohol and Other Medications: Avoid alcohol while taking Meprobamate, as it can enhance the sedative effects of the medication. Additionally, inform your healthcare provider about all other medications, supplements, or herbal products you are taking to check for potential drug interactions.
  • Driving and Operating Machinery: Meprobamate can cause dizziness and impair your ability to concentrate. It is advisable to avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
  • Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. They will monitor your progress and may make adjustments to your treatment plan as needed.

Always communicate openly with your healthcare provider about your response to the medication, any side effects you experience, and any concerns you may have. It’s essential to use Meprobamate as part of a comprehensive treatment plan that may include therapy or other strategies for managing the underlying condition being treated.

Other uses for this medicine

Some other uses for meprobamate that were less common include:

  • Alcohol Withdrawal: Meprobamate has been used in the past to manage symptoms of alcohol withdrawal, including anxiety and agitation.
  • Premenstrual Syndrome (PMS): In some cases, meprobamate has been prescribed to alleviate symptoms of PMS, such as mood swings and irritability.

What special precautions should I follow?

If you are prescribed meprobamate or considering its use (though it’s rarely prescribed today), you should be aware of the following precautions:

  • Medical Supervision: Meprobamate should only be used under the direct supervision and guidance of a qualified healthcare provider. It should not be used without a prescription.
  • Potential for Dependence: Meprobamate has a risk of dependence and abuse. It should be used with caution, especially in individuals with a history of substance abuse or addiction.
  • Drowsiness: Meprobamate can cause drowsiness and impaired coordination. It is essential to avoid activities that require mental alertness, such as driving or operating heavy machinery, while taking this medication.
  • Alcohol and Other Sedatives: It is important to avoid alcohol and other sedative medications while taking meprobamate, as they can enhance its sedative effects and increase the risk of adverse reactions.
  • Pregnancy and Breastfeeding: Meprobamate should be used with caution during pregnancy and breastfeeding, as its safety in these situations may not be well-established. It’s important to discuss the risks and benefits with your healthcare provider.
  • Allergies and Sensitivities: Inform your healthcare provider of any allergies or sensitivities you may have to medications, as well as any other medical conditions you may be experiencing.

The use of meprobamate may have evolved since then, and it’s crucial to consult with a healthcare provider for the most up-to-date information and guidance regarding its use or alternative treatments for specific medical conditions

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Meprobamate. However, it’s generally advisable to take this medication with food or milk if it upsets your stomach. This may help reduce gastrointestinal discomfort.

What should I do if I forget a dose?

If you forget to take a dose of Meprobamate, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses to make up for a missed one, as this can increase the risk of side effects.

What side effects can this medication cause?

Here are some potential side effects associated with meprobamate:

Common Side Effects:

  • Drowsiness: Meprobamate is known for its sedative effects, and drowsiness is a common side effect. This can impair your ability to drive or operate machinery safely.
  • Dizziness: Some people may experience feelings of dizziness or lightheadedness while taking meprobamate.
  • Nausea: Nausea or stomach upset can occur in some individuals.
  • Headache: Headaches are a relatively common side effect.
  • Blurred Vision: Meprobamate can sometimes cause blurred vision.

Less Common Side Effects:

  • Confusion: Some people may experience confusion or difficulty concentrating.
  • Weakness: A feeling of weakness or fatigue can occur.
  • Skin Rash: Skin rash or itching is a less common side effect.
  • Hives: In rare cases, meprobamate can cause hives (raised, itchy skin welts).
  • Allergic Reactions: While rare, allergic reactions to meprobamate can occur. Signs of an allergic reaction may include difficulty breathing, swelling of the face, lips, tongue, or throat, and hives. Seek immediate medical attention if you experience these symptoms.
  • Dependence and Withdrawal: Prolonged or high-dose use of meprobamate can lead to physical and psychological dependence. Abruptly stopping the medication after long-term use can result in withdrawal symptoms such as anxiety, restlessness, and insomnia.

It’s essential to take meprobamate exactly as prescribed by your healthcare provider and to report any unusual or severe side effects to them promptly. Additionally, because meprobamate has a potential for dependence and abuse, it should be used with caution and only as directed by a medical professional.

What should I know about storage and disposal of this medication?


  • Keep in a Safe Location: Store meprobamate in a safe and secure location out of reach of children and pets. Medications should be stored in a place where they cannot be accidentally ingested.
  • Room Temperature: Store meprobamate at room temperature, away from excessive heat, moisture, and direct sunlight. Avoid storing it in the bathroom or kitchen, as these areas can be humid.
  • Original Packaging: Keep the medication in its original packaging or container to ensure it’s labeled correctly and to prevent any mix-ups with other medications.
  • Child-Resistant Container: If your meprobamate prescription comes in a child-resistant container, make sure to close it tightly after each use.


If you have expired or unused Meprobamate, do not keep it in your medicine cabinet indefinitely. Follow your local guidelines or the specific recommendations from your healthcare provider or pharmacist on how to safely dispose of it. Many areas have medication take-back programs or drop-off locations. If those options are not available, you can dispose of the medication by mixing it with an undesirable substance (like coffee grounds or cat litter) in a sealed bag and throwing it in the household trash. Be sure to remove any personal information from the medication container before disposal.

In case of emergency/overdose

In case of an emergency or suspected overdose, here’s what you should do:

  • Seek Medical Attention: If you or someone you know may have taken an overdose of meprobamate or is experiencing severe symptoms, call 911 or go to the nearest emergency room immediately.
  • Poison Control: You can also contact your local poison control center at 1-800-222-1222 for guidance on how to handle a suspected overdose.

What other information should I know

Here are some additional points to consider:

  • Follow Prescribing Instructions: Take meprobamate exactly as prescribed by your healthcare provider. Do not exceed the prescribed dose or use it for longer than recommended.
  • Inform Your Healthcare Provider: Inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs, supplements, and herbal products, as they can interact with meprobamate.
  • Avoid Alcohol: Avoid alcohol while taking meprobamate, as it can enhance the sedative effects and increase the risk of side effects.
  • Regular Follow-Up: If you are prescribed meprobamate, schedule regular follow-up appointments with your healthcare provider to monitor your progress and adjust your treatment plan as needed.

Medication guidelines and recommendations can change over time, so always consult with your healthcare provider or pharmacist for the most up-to-date information and guidance regarding the use, storage, and disposal of meprobamate or any other medication.

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