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MetroGel Vaginal (Generic Metronidazole Vaginal)

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Why is this medication prescribed?

MetroGel Vaginal is a prescription medication primarily prescribed for the treatment of bacterial vaginosis, a common vaginal infection. Bacterial vaginosis occurs when there is an overgrowth of certain bacteria in the vagina, leading to symptoms such as vaginal discharge, odor, itching, and irritation.

How should this medicine be used?

MetroGel Vaginal (metronidazole vaginal gel) is a medication used to treat certain vaginal infections, including bacterial vaginosis. It is important to use MetroGel Vaginal exactly as prescribed by your healthcare provider. Here are the general guidelines for how to use MetroGel Vaginal:

  • Wash your hands: Before using the medication, thoroughly wash your hands with soap and water to prevent the spread of bacteria and ensure proper hygiene.
  • Preparing the applicator: Open the package containing the MetroGel Vaginal applicator. Attach the applicator to the tube of gel.
  • Lie down: It is usually recommended to lie down on your back with your knees bent and feet apart, or you can also assume a comfortable position.
  • Fill the applicator: Squeeze the tube of MetroGel to fill the applicator with the prescribed dose of gel.
  • Insert the applicator: Gently insert the filled applicator into the vagina as far as it comfortably goes. This is usually done at bedtime to allow the medication to stay in place overnight.
  • Dispense the gel: Push the plunger on the applicator to dispense the gel into the vagina. Withdraw the applicator slowly to ensure that all the gel is released.
  • Remove the applicator: Carefully remove the applicator from the vagina and dispose of it in the trash. Do not flush the applicator down the toilet.
  • Wash your hands again: After using the applicator, wash your hands again with soap and water.
  • Follow the prescribed treatment course: Use MetroGel Vaginal for the full course of treatment, even if your symptoms improve before the medication is finished. It’s important to complete the entire prescribed regimen to ensure that the infection is fully treated.
  • Avoid sexual activity during treatment: It’s generally recommended to avoid sexual intercourse while using MetroGel Vaginal, as it can weaken latex condoms and diaphragms. If you have sexual intercourse during treatment, use alternative forms of contraception.
  • Follow your healthcare provider’s instructions: Be sure to follow any additional instructions or precautions provided by your healthcare provider.

If you experience any irritation, itching, or burning while using MetroGel Vaginal, or if your symptoms worsen or do not improve, contact your healthcare provider for further guidance. Additionally, inform your healthcare provider of any other medications you are taking, as there may be potential drug interactions. Always use MetroGel Vaginal as directed and complete the full course of treatment to ensure the best possible outcome.

Other uses for this medicine

Some potential off-label uses of MetroGel Vaginal include:

  • Trichomoniasis: MetroGel Vaginal may be prescribed to treat trichomoniasis, a sexually transmitted infection caused by the parasite Trichomonas vaginalis. However, oral metronidazole is more commonly used for treating trichomoniasis.
  • Certain Anaerobic Infections: In some cases, MetroGel Vaginal may be prescribed for the treatment of other localized anaerobic infections.

What special precautions should I follow?

As for special precautions when using MetroGel Vaginal:

  • Allergies: Inform your healthcare provider of any known allergies to metronidazole or other medications. If you have had an allergic reaction to metronidazole or a similar drug in the past, it’s crucial to let your healthcare provider know.
  • Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant or breastfeeding, as they will need to weigh the potential benefits of the medication against any potential risks to the baby.
  • Alcohol Consumption: Avoid consuming alcoholic beverages while using MetroGel Vaginal and for at least 24 hours after the last dose. Combining metronidazole with alcohol can lead to severe nausea, vomiting, and other side effects.
  • Other Medications: Make sure your healthcare provider is aware of all the medications you are currently taking, including prescription drugs, over-the-counter medicines, vitamins, and supplements. Some medications may interact with metronidazole.
  • Use of Barrier Contraceptives: As mentioned earlier, metronidazole can weaken latex condoms and diaphragms. If you are using these methods of contraception, consider using an alternative form of birth control during treatment with MetroGel Vaginal and for at least 72 hours afterward.
  • Side Effects: Be aware of potential side effects such as vaginal irritation, burning, or itching. If these side effects are severe or bothersome, contact your healthcare provider.
  • Follow-Up: Attend any follow-up appointments or testing recommended by your healthcare provider to ensure that the infection has been successfully treated.

Always use MetroGel Vaginal as prescribed and directed by your healthcare provider, and do not use it for any condition other than what it was prescribed for unless instructed to do so by a healthcare professional. If you have any questions or concerns about this medication, consult your healthcare provider for guidance.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with MetroGel Vaginal. However, you should follow a healthy and balanced diet to support your overall well-being during treatment. Maintaining good nutrition can help your body recover from infection more effectively.

What should I do if I forget a dose?

If you miss a dose of MetroGel Vaginal, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for the missed one.

What side effects can this medication cause?

MetroGel Vaginal (metronidazole vaginal gel) can cause side effects, although not everyone will experience them, and the severity of side effects can vary from person to person. Some common and less common side effects of MetroGel Vaginal may include:

Common Side Effects:

  • Vaginal Discomfort: This may include irritation, burning, itching, or a feeling of dryness in the vaginal area.
  • Vaginal Discharge: You may experience an increase in vaginal discharge during treatment. This is often temporary and a normal response to the medication.
  • Unusual Taste: Some people may notice a metallic or bitter taste in the mouth while using the medication.
  • Nausea: Nausea is a possible side effect, although it’s less common when using the vaginal gel compared to the oral form of metronidazole.

Less Common Side Effects:

  • Headache: Some individuals may experience mild to moderate headaches.
  • Dizziness: Dizziness can occur in some cases.
  • Stomach Cramps or Abdominal Pain: This side effect is less common but can happen.
  • Allergic Reactions: Although rare, some individuals may develop an allergic reaction to metronidazole, which can include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.

It’s important to note that the occurrence and severity of side effects can vary, and not everyone will experience them. If you experience any severe or bothersome side effects while using MetroGel Vaginal, or if you have concerns about the medication, contact your healthcare provider. They can provide guidance on how to manage side effects or may adjust your treatment if necessary.

What should I know about storage and disposal of this medication?

Regarding storage and disposal, here are some guidelines:


  • Store MetroGel Vaginal at room temperature, away from excessive heat and moisture.
  • Keep the medication out of the reach of children and pets.
  • Do not freeze the medication.


  • Dispose of any unused or expired MetroGel Vaginal in a safe and environmentally responsible manner. Do not flush it down the toilet unless specifically instructed to do so.
  • You can check with your local pharmacy or healthcare provider for guidance on proper medication disposal options in your area. Many communities have medication disposal programs or locations.

In case of emergency or suspicion of an overdose, take the following steps:

If you suspect an overdose or experience severe symptoms, seek immediate medical attention or contact a poison control center (in the United States, you can call 1-800-222-1222). Signs of an overdose can include severe nausea, vomiting, loss of coordination, and seizures.

What other information should I know

  • MetroGel Vaginal is a prescription medication and should only be used under the guidance and supervision of a healthcare provider.
  • Do not share this medication with others, even if they have similar symptoms. It is prescribed based on your specific condition and needs.
  • Finish the full course of treatment, even if your symptoms improve before you complete the prescribed duration. Stopping the medication prematurely may lead to a recurrence of the infection.
  • It’s essential to avoid sexual activity during the treatment period and for at least 24 hours after the last dose of MetroGel Vaginal. As mentioned earlier, metronidazole can weaken latex condoms and diaphragms, reducing their effectiveness.
  • Inform your healthcare provider of any other medications, supplements, or herbal products you are taking to ensure there are no potential drug interactions.
  • If you experience any unexpected or severe side effects while using MetroGel Vaginal, contact your healthcare provider promptly.
  • Follow your healthcare provider’s instructions for follow-up appointments or testing to ensure that the infection has been successfully treated.
  • Consult your healthcare provider or pharmacist if you have any additional questions or concerns about MetroGel Vaginal or its use.

Always use MetroGel Vaginal as directed by your healthcare provider and follow their recommendations for safe storage, disposal, and handling of the medication. Your healthcare provider can provide specific guidance based on your individual circumstances and needs.

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