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Why is this medication prescribed?

Methylergonovine is a medication prescribed for specific medical conditions, primarily related to the uterus and its contractions. Methylergonovine is a member of the ergot alkaloids drug class. Methylergonovine is used to stop or treat uterine bleeding that may occur following childbirth or an abortion.

How should this medicine be used?

Methylergonovine should only be used under the supervision and guidance of a qualified healthcare provider, as its dosage and administration can vary based on the specific medical condition being treated and the patient’s individual circumstances. It is typically available in tablet and injectable forms. Here are some general guidelines on how Methylergonovine may be used:

  • Postpartum Hemorrhage and Uterine Atony: When used to manage postpartum hemorrhage or uterine atony after childbirth, Methylergonovine is usually administered as an injection (intramuscular or intravenous) in a healthcare setting, such as a hospital. The typical dosage is 0.2 mg (milligrams) given slowly, and it may be repeated at intervals if necessary. The total dosage and frequency will be determined by the healthcare provider based on the severity of bleeding and the patient’s response.
  • Migraine Headaches: When used for the treatment of migraines, Methylergonovine is typically taken orally in tablet form. The usual recommended dose is 0.2 mg to 0.4 mg, taken at the onset of a migraine headache and repeated as needed every 6 to 8 hours. However, the dosage and frequency can vary based on individual response and the healthcare provider’s recommendations.

It’s important to follow your healthcare provider’s instructions precisely regarding the dosage and administration of Methylergonovine. Do not exceed the prescribed dose or frequency, as it may lead to side effects or adverse reactions. If you have any questions or concerns about how to use this medication, be sure to discuss them with your healthcare provider.

Methylergonovine should not be used during pregnancy, as it can cause uterine contractions and potential harm to the fetus. Additionally, inform your healthcare provider about any other medications, supplements, or medical conditions you have, as there may be interactions or contraindications to consider.

Other uses for this medicine

Methylergonovine is primarily used for the conditions mentioned earlier, such as postpartum hemorrhage, uterine atony after childbirth, and the treatment of severe migraine headaches. However, it’s important to note that healthcare providers may sometimes prescribe medications for off-label uses. Any such use should be carefully considered by a healthcare provider based on the patient’s specific needs and medical history.

What special precautions should I follow?

As for special precautions when using Methylergonovine, here are some important considerations:

  • Pregnancy: Methylergonovine should not be used during pregnancy unless it is specifically indicated by a healthcare provider for a medical reason. It can stimulate uterine contractions, which may pose a risk to the developing fetus.
  • Breastfeeding: It is not recommended to breastfeed while taking Methylergonovine, as the medication may pass into breast milk. Discuss the potential risks and benefits with your healthcare provider if you are breastfeeding.
  • Liver or Kidney Impairment: Individuals with significant liver or kidney problems may require dosage adjustments or special monitoring while using Methylergonovine. Your healthcare provider will assess your specific situation and make appropriate recommendations.
  • Hypertension (High Blood Pressure): Methylergonovine can lead to an increase in blood pressure. If you have a history of hypertension or other cardiovascular issues, your healthcare provider will need to closely monitor your blood pressure while you are on this medication.
  • Allergies and Sensitivities: Inform your healthcare provider about any known allergies or sensitivities to medications or substances, as well as any adverse reactions you may have had to other ergot alkaloids.
  • Interactions: Methylergonovine may interact with other medications you are taking. Be sure to inform your healthcare provider about all prescription drugs, over-the-counter medications, supplements, and herbal products you are using to avoid potential drug interactions.
  • Side Effects: Be aware of potential side effects of Methylergonovine, which can include nausea, vomiting, headache, dizziness, and increased blood pressure. If you experience any severe or persistent side effects, contact your healthcare provider.

Always follow your healthcare provider’s instructions and guidance when using Methylergonovine or any other medication. They will take into account your individual medical history and needs to ensure safe and effective treatment. If you have any concerns or questions about this medication, do not hesitate to discuss them with your healthcare provider.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with Methylergonovine use. However, it’s important to take the medication as prescribed by your healthcare provider and follow any general dietary recommendations they provide for your overall health and well-being.

What should I do if I forget a dose?

If you forget a dose of Methylergonovine, here’s what you should do:

  • If you’re taking Methylergonovine for Postpartum Hemorrhage or Uterine Atony: Contact your healthcare provider or the healthcare facility where you received the injection as soon as possible to discuss the missed dose. They will provide guidance on whether or not a makeup dose is necessary.
  • If you’re taking Methylergonovine for Migraine Headaches: Take the missed dose as soon as you remember, but do not take it if it’s close to the time for your next scheduled dose. In that case, simply resume your regular dosing schedule. Do not double up on doses to make up for the missed one.

What side effects can this medication cause?

Methylergonovine, like any medication, can cause side effects in some individuals. Not everyone will experience these side effects, and the severity and likelihood of side effects can vary from person to person. Common side effects of Methylergonovine may include:

  • Nausea and Vomiting: Gastrointestinal symptoms, such as nausea and vomiting, are among the most common side effects of Methylergonovine.
  • Headache: Some individuals may experience headache as a side effect of the medication.
  • Dizziness: Methylergonovine can cause dizziness or lightheadedness in some people, which may be more pronounced if you stand up quickly from a sitting or lying position.
  • Increased Blood Pressure: Methylergonovine can lead to an increase in blood pressure, and individuals with a history of hypertension (high blood pressure) may be more susceptible to this side effect.
  • Muscle Cramps or Pain: Some individuals may experience muscle cramps or pain as a side effect of the medication.
  • Nasal Congestion: Nasal congestion or a stuffy nose can occur as a side effect of Methylergonovine.
  • Cold or Numb Fingers or Toes: Methylergonovine can cause vasoconstriction (narrowing of blood vessels), which may lead to sensations of cold or numbness in the fingers or toes.
  • Allergic Reactions: Although rare, allergic reactions to Methylergonovine can occur. Seek immediate medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s important to report any side effects you experience to your healthcare provider, especially if they are severe, persistent, or concerning. Your healthcare provider will be able to assess whether the benefits of Methylergonovine outweigh the potential risks and whether any adjustments to your treatment plan are necessary.

Additionally, Methylergonovine should not be used without a prescription and should only be taken under the supervision of a qualified healthcare provider who can monitor for side effects and provide appropriate guidance.

What should I know about storage and disposal of this medication?


  • Store Methylergonovine as directed by your healthcare provider or pharmacist. Typically, it should be kept at room temperature away from excessive heat and moisture.
  • Keep the medication out of the reach of children and pets, as Methylergonovine should only be used under medical supervision.


  • Do not keep Methylergonovine that is no longer needed or has expired. Safely dispose of any unused medication to prevent accidental ingestion.
  • To dispose of Methylergonovine properly, follow any local or national guidelines for the disposal of pharmaceutical waste. Some communities have take-back programs or special disposal instructions for medications.

In case of emergency/overdose

In case of an emergency or suspected overdose of Methylergonovine, seek immediate medical attention or contact a poison control center at 1-800-222-1222 (if available in your country).

What other information should I know

  • Inform all healthcare providers involved in your care about any medications you are taking, including Methylergonovine. This helps them make informed decisions about your treatment.
  • Follow your healthcare provider’s instructions carefully regarding the dosage and administration of Methylergonovine. Do not exceed the prescribed dose or take it more frequently than recommended.
  • If you experience any unusual or severe side effects while taking Methylergonovine, contact your healthcare provider promptly.
  • It’s important to attend all scheduled follow-up appointments with your healthcare provider to monitor your progress and response to the medication.
  • Do not share Methylergonovine with others, even if they have similar symptoms or conditions, as it is prescribed based on individual medical assessments.
  • Methylergonovine may interact with other medications you are taking, so inform your healthcare provider about all the medications, supplements, and herbal products you are using.
  • If you have any questions or concerns about Methylergonovine or your treatment plan, don’t hesitate to discuss them with your healthcare provider or pharmacist.

Always follow your healthcare provider’s guidance and recommendations when it comes to the use of Methylergonovine, and use the medication responsibly and safely.

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