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Methyldopa and Hydrochlorothiazide

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Why is this medication prescribed?

High blood pressure is treated with methyldopa and hydrochlorothiazide together. Methyldopa works by relaxing blood arteries to improve blood flow throughout the body. By removing surplus salt and water from the body, the blood pressure-lowering drug hydrochlorothiazide helps.

The brain, heart, blood vessels, kidneys, and other organs can be harmed by high blood pressure, a frequent disorder that can be managed or prevented by using proper medication. Loss of vision, heart disease, a heart attack, heart failure, a stroke, kidney failure, and other issues may result from damage to these organs. Altering your lifestyle will aid in blood pressure control in addition to taking medication. A low-fat, low-sodium diet, keeping a healthy weight, engaging in at least 30 minutes of exercise most days, quitting smoking, and drinking in moderation are just a few of these adjustments.

How should this medicine be used?

The oral tablet form of this drug is provided. It is typically taken twice or three times daily. Take your medications at roughly the same times each day to help you remember to take your methyldopa and hydrochlorothiazide. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Methyldopa and hydrochlorothiazide should be taken exactly as prescribed. Never take it in quantities or frequencies other than those recommended by your doctor.

High blood pressure is not cured by this medicine, although it does moderate it. Despite feeling fine, keep taking hydrochlorothiazide and methyldopa. Hydrochlorothiazide and methyldopa should not be stopped without consulting a physician.

Other uses for this medicine

Another purpose for this medication’s prescription is possible. To learn more, consult your physician or pharmacist.

What special precautions should I follow?

Methyldopa and Hydrochlorothiazide are medications used to treat high blood pressure (hypertension). It’s important to follow your healthcare provider’s instructions carefully when taking these medications. Here are some special precautions, dietary instructions, and what to do if you forget a dose:

Special Precautions:

  • Follow your doctor’s instructions: Always take Methyldopa and Hydrochlorothiazide exactly as prescribed by your healthcare provider. Do not change the dose or stop taking the medication without consulting your doctor.
  • Regular monitoring: Your healthcare provider may require regular blood pressure checks and lab tests to monitor your response to these medications and check for any potential side effects.
  • Avoid alcohol: Alcohol may increase the blood pressure-lowering effects of Methyldopa and can cause dizziness and lightheadedness. It’s best to avoid alcohol or limit its consumption while taking these medications.
  • Driving and machinery: Methyldopa and Hydrochlorothiazide can cause dizziness or drowsiness. If you experience these side effects, avoid activities that require mental alertness, such as driving or operating heavy machinery.
  • Orthostatic hypotension: These medications can cause a sudden drop in blood pressure when you stand up from a sitting or lying position (orthostatic hypotension). To minimize this risk, rise slowly from a seated or lying position.
  • Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of these medications with your healthcare provider. They will weigh the benefits and risks and may suggest alternative medications.

Always consult with your healthcare provider for personalized advice and precautions related to the use of Methylnaltrexone, especially if you have concerns or are considering its use for off-label purposes. Your healthcare provider can assess whether it is an appropriate option for your specific medical condition and needs.

What special dietary instructions should I follow?

Special Dietary Instructions for Methyldopa or Hydrochlorothiazide:

  • Dietary sodium: Hydrochlorothiazide is a diuretic that can increase the excretion of sodium and water. Depending on your specific medical condition, your doctor may recommend dietary changes to control your sodium intake. Reducing sodium can help manage fluid balance and blood pressure.
  • Potassium-rich foods: Diuretics like Hydrochlorothiazide can lead to potassium loss. To counteract this, you may be advised to include potassium-rich foods in your diet, such as bananas, oranges, potatoes, and spinach. However, always follow your doctor’s recommendations, as they will tailor your dietary advice to your specific needs.

What should I do if I forget a dose?

If you forget to take a dose of Methyldopa or Hydrochlorothiazide, follow these guidelines:

  • Take it as soon as you remember: If it’s not too close to the time for your next scheduled dose, take the missed dose immediately.
  • Skip it if it’s almost time for the next dose: If it’s close to the time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not take a double dose to make up for the missed one.
  • Consult your healthcare provider: If you are unsure about what to do or have questions about missed doses, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Methyldopa and hydrochlorothiazide are medications used to treat high blood pressure (hypertension). They work in different ways and can have various side effects. Here are some of the potential side effects of each medication:

  • Electrolyte imbalance: Hydrochlorothiazide is a diuretic (water pill) that can cause an imbalance in electrolytes such as potassium, sodium, and magnesium. This can lead to muscle cramps, weakness, irregular heartbeats, or other symptoms.
  • Dehydration: Since it increases urination, hydrochlorothiazide can lead to dehydration in some individuals. Signs of dehydration may include dry mouth, extreme thirst, dark urine, and fatigue.
  • Low blood pressure: Hydrochlorothiazide can sometimes cause low blood pressure, leading to dizziness or fainting.
  • Increased blood sugar levels: It may raise blood sugar levels, which can be a concern for individuals with diabetes.
  • Increased uric acid levels: Hydrochlorothiazide can increase uric acid levels in the blood, which may worsen gout or lead to new cases of gout.
  • Skin reactions: Some people may experience skin reactions like rash or photosensitivity (increased sensitivity to sunlight).
  • Drowsiness or dizziness: Methyldopa can cause drowsiness or dizziness, which can impair your ability to concentrate or operate machinery. It’s important to avoid activities that require alertness until you know how this medication affects you.
  • Dry mouth: Some people may experience a dry mouth while taking methyldopa.
  • Orthostatic hypotension: This is a sudden drop in blood pressure when you stand up from a sitting or lying position. It can lead to dizziness or fainting.
  • Depression: Methyldopa can cause or worsen symptoms of depression in some individuals.
  • Liver problems: In rare cases, methyldopa can affect liver function, leading to jaundice (yellowing of the skin and eyes), dark urine, and other symptoms of liver dysfunction.

It’s important to note that not everyone will experience these side effects, and some individuals may tolerate these medications well. Your doctor will weigh the potential benefits against the risks when prescribing these medications, and they will monitor your response and side effects during treatment. If you experience any concerning or severe side effects, you should contact your healthcare provider promptly. Additionally, it’s important to follow your healthcare provider’s instructions and attend regular follow-up appointments while taking these medications.

What should I know about storage and disposal of this medication?


  • Storage Conditions: Store Methyldopa and Hydrochlorothiazide at room temperature, away from excessive heat, moisture, and direct sunlight. Follow the specific storage instructions provided on the medication packaging or by your pharmacist.
  • Keep Out of Reach of Children and Pets: Store these medications in a place that is out of the reach of children and pets, as accidental ingestion can be harmful.
  • Original Containers: Keep the medications in their original containers to avoid confusion with other drugs.


  • Proper Disposal: Dispose of any unused or expired Methyldopa and Hydrochlorothiazide properly. Do not flush them down the toilet or throw them in the trash unless directed to do so. Instead, take them to a medication disposal program or facility in your community. Many pharmacies and law enforcement agencies provide options for safe disposal.
  • Do Not Share Medication: Do not share your prescription medications with others, even if they have similar symptoms or conditions. Medications should only be taken under the guidance of a healthcare provider.

In case of emergency/overdose

  • In Case of Emergency: If you or someone you are with experiences severe symptoms or signs of an overdose, such as extreme dizziness, fainting, difficulty breathing, irregular heartbeat, or loss of consciousness, call emergency services (911 in the United States) immediately.
  • Poison Control: If you suspect an overdose but the person is conscious and alert, you can contact your local poison control center for guidance. They can provide information on what steps to take and can advise you on the appropriate next steps.

What other information should I know

  • Follow Healthcare Provider’s Instructions: Take Methyldopa and Hydrochlorothiazide exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your healthcare provider, as doing so can affect your blood pressure control.
  • Regular Check-ups: It’s important to attend follow-up appointments with your healthcare provider to monitor your progress and make any necessary adjustments to your treatment plan.
  • Drug Interactions: Inform your healthcare provider and pharmacist about all the medications, supplements, and herbal products you are taking to check for potential drug interactions.
  • Adverse Effects: Be aware of potential side effects and report any unusual or severe symptoms to your healthcare provider promptly.
  • Allergies: If you have known allergies to Methyldopa, Hydrochlorothiazide, or any other medications, inform your healthcare provider and pharmacist.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of taking these medications with your healthcare provider.
  • Medical Conditions: Inform your healthcare provider of any preexisting medical conditions you may have, especially kidney or liver problems.

Remember that the information provided here is for general guidance, and it’s essential to follow your healthcare provider’s specific instructions and recommendations regarding Methyldopa and Hydrochlorothiazide. If you have any questions or concerns about these medications or your treatment plan, do not hesitate to reach out to your healthcare provider or pharmacist for clarification and guidance.

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