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Methergine (Generic Methylergonovine)

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Why is this medication prescribed?

Methergine is a brand name for the medication Methylergonovine. It is primarily prescribed for the prevention and treatment of uterine bleeding following childbirth or after certain medical procedures involving the uterus. Methergine works by constricting the blood vessels in the uterus, which can help control excessive bleeding.

How should this medicine be used?

Here are some guidelines on how Methergine is typically used:

  • Dosage: The dosage of Methergine can vary depending on the specific medical condition and the healthcare provider’s recommendations. It is available in different forms, including tablets and injections.
  • Postpartum Hemorrhage: In cases of postpartum hemorrhage (excessive bleeding after childbirth), Methergine may be administered either orally. The usual oral dose for postpartum hemorrhage is typically 0.2 mg every 6 to 12 hours, but the specific dosage and frequency will depend on the healthcare provider’s assessment of the situation. For intramuscular or intravenous injection, the dosage may vary as well.
  • Uterine Atony: Methergine is also used to treat uterine atony, a condition where the uterus does not contract properly after childbirth.
  • Medical Procedures: Methergine may be used after certain gynecological procedures, such as dilation and curettage (D&C), to help control uterine bleeding. The dosage and method of administration will be determined by the healthcare provider.
  • Follow Instructions: It is crucial to follow your healthcare provider’s instructions regarding the dosage, frequency, and method of administration. Do not exceed the prescribed dose.
  • Side Effects: Like all medications, Methergine can have side effects, including nausea, vomiting, headache, high blood pressure, and abdominal pain. If you experience any unusual or severe side effects, contact your healthcare provider immediately.
  • Contraindications: Methergine should not be used in certain situations, such as if you have a history of hypertension (high blood pressure), coronary artery disease, or other cardiovascular conditions. It is important to inform your healthcare provider about your medical history and any other medications you may be taking.
  • Pregnancy and Breastfeeding: Methergine is not typically prescribed during pregnancy unless the potential benefits outweigh the risks. It may be excreted in breast milk, so it should be used cautiously during breastfeeding.

Always consult with your healthcare provider for personalized guidance on the use of Methergine, and be sure to inform them of any existing medical conditions or medications you are taking to avoid potential interactions or complications. This information is provided as a general guideline and should not substitute for professional medical advice.

Other uses for this medicine

The use of Methergine for conditions other than postpartum hemorrhage should only be done under the direction and supervision of a qualified healthcare provider, as the medication can have potential side effects and interactions with other drugs. Always consult with your healthcare provider for proper guidance and dosing instructions.

What special precautions should I follow?

Regarding special precautions when using Methergine, here are some important considerations:

  • Medical History: Inform your healthcare provider of your complete medical history, including any history of cardiovascular problems, high blood pressure, liver disease, kidney disease, or allergies.
  • Medication Interactions: Methergine may interact with certain medications, including other medications that affect blood pressure. Be sure to provide a list of all medications, supplements, and herbal products you are taking to your healthcare provider.
  • Allergies: If you have known allergies to Methergine or any of its components, inform your healthcare provider.
  • Pregnancy and Breastfeeding: Methergine is not typically prescribed during pregnancy unless the potential benefits outweigh the risks. If you are pregnant or planning to become pregnant, discuss this with your healthcare provider. Methergine may also be excreted in breast milk, so it should be used cautiously during breastfeeding.
  • Blood Pressure Monitoring: Since Methergine can raise blood pressure, your healthcare provider will likely monitor your blood pressure while you are taking the medication. If you have a history of high blood pressure or other cardiovascular conditions, special caution is necessary.
  • Side Effects: Be aware of potential side effects, including nausea, vomiting, headache, abdominal pain, and high blood pressure. Report any severe or unusual side effects to your healthcare provider.

Always follow your healthcare provider’s instructions and recommendations when using Methergine, and do not adjust the dosage or frequency without their guidance. This information is provided as a general guideline and should not replace personalized medical advice from a qualified healthcare professional.

What special dietary instructions should I follow?

There are no specific dietary instructions that are typically associated with Methergine (Methylergonovine) use. However, it’s essential to follow your healthcare provider’s instructions regarding your diet and any potential dietary restrictions, especially if you have any underlying medical conditions or are taking other medications that may interact with Methergine.

What should I do if I forget a dose?

If you forget to take a dose of Methergine, here’s what you should do:

  • If It’s Close to the Missed Dose Time: If you realize you missed a dose but it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
  • If There’s Significant Time Before the Next Dose: If you have a significant amount of time before your next scheduled dose, take the missed dose as soon as you remember. Then, continue with your regular dosing schedule.

What side effects can this medication cause?

Methergine (Methylergonovine) can cause side effects, and it’s essential to be aware of these potential reactions while taking the medication. Not everyone will experience side effects, and some individuals may experience them more severely than others. Common side effects of Methergine may include:

  • Nausea and Vomiting: Nausea and vomiting are among the most common side effects of Methergine. Taking the medication with food or milk may help reduce the likelihood of these symptoms.
  • Headache: Some individuals may experience headaches while taking Methergine.
  • Abdominal Pain: Abdominal pain or discomfort can occur as a side effect.
  • High Blood Pressure: Methergine can cause an increase in blood pressure, so it is important for your healthcare provider to monitor your blood pressure regularly while you are on this medication.
  • Dizziness or Lightheadedness: Some people may feel dizzy or lightheaded while taking Methergine, especially when changing positions (e.g., standing up from a sitting or lying position). This is more likely if you have a history of low blood pressure.
  • Nasal Congestion: In some cases, Methergine may cause nasal congestion or a stuffy nose.
  • Chest Pain: Although less common, some individuals may experience chest pain while taking Methergine. This symptom should be reported to a healthcare provider promptly.
  • Other Less Common Side Effects: Methergine may also rarely cause other side effects, such as diarrhea, sweating, or cold and clammy skin.

It’s important to note that Methergine should not be used in individuals with a history of coronary artery disease, hypertension, or other cardiovascular conditions, as it can raise blood pressure and potentially exacerbate these conditions.

If you experience any severe or unusual side effects, such as severe chest pain, shortness of breath, severe headache, or signs of an allergic reaction (e.g., rash, itching, swelling, severe dizziness), seek immediate medical attention. These could be signs of a serious adverse reaction.

Always discuss any side effects or concerns with your healthcare provider. They can provide guidance on managing side effects and determine whether the benefits of Methergine outweigh the potential risks for your specific medical condition. This information is provided as a general overview, and individual experiences with medications can vary.

What should I know about storage and disposal of this medication?


  • Store Methergine at room temperature, away from excessive heat and moisture.
  • Keep the medication out of the reach of children and pets, as Methergine should only be used under the supervision of a healthcare provider.


  • Do not keep expired or unused Methergine. When you have finished your course of treatment or if the medication has expired, follow proper disposal guidelines.
  • Do not flush Methergine down the toilet or pour it down the drain unless instructed to do so. Check with your healthcare provider or local pharmacy for specific disposal instructions in your area.

In case of emergency/overdose

In case of an emergency or suspected overdose of Methyldopa:

  • If you suspect an overdose of Methergine or if someone has ingested the medication accidentally, seek immediate medical attention or contact your local poison control center (in the United States, you can reach the Poison Help hotline at 1-800-222-1222).
  • Symptoms of overdose may include severe nausea, vomiting, severe headache, high blood pressure, seizures, and potentially life-threatening complications. It’s crucial to get medical help promptly in such cases.

What other information should I know?

  • Always take Methergine exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking it without their guidance.
  • Inform all healthcare providers, including dentists and specialists, that you are taking Methergine. This is important in case of any procedures or surgeries, as Methergine can affect blood pressure and may interact with other medications.
  • Keep a record of your blood pressure readings while taking Methergine if your healthcare provider has advised you to monitor your blood pressure at home.
  • Do not share Methergine with others, as it is prescribed based on individual medical conditions and needs.
  • If you experience any side effects or have concerns about the medication, discuss them with your healthcare provider. They can provide guidance and make any necessary adjustments to your treatment plan.
  • Follow all dietary and lifestyle recommendations provided by your healthcare provider to manage any potential side effects or risks associated with Methergine.
  • If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Methergine with your healthcare provider. They can provide guidance on its safety and potential risks in these situations.

Always rely on the advice and instructions of your healthcare provider when it comes to the use of Methergine, as they can provide personalized guidance based on your medical history and specific needs.

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