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Metaglip (Generic Glipizide)

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Why is this medication prescribed?

Glipizide is a medication commonly prescribed to manage high blood sugar levels in people with type 2 diabetes. It belongs to a class of drugs known as sulfonylureas, which work by stimulating the pancreas to release more insulin and by increasing the sensitivity of the body’s cells to insulin. Insulin is a hormone that helps regulate blood sugar (glucose) levels.

How should this medicine be used?

Here’s how Glipizide is typically prescribed and used:

  • Prescription: A healthcare provider, usually an endocrinologist or a primary care physician, prescribes Glipizide when they determine that a patient with type 2 diabetes requires medication to control their blood sugar levels. It is often prescribed when lifestyle changes like diet and exercise alone are insufficient to manage blood sugar.
  • Dosage: The specific dosage of Glipizide can vary from person to person and is determined by the healthcare provider based on factors such as the individual’s blood sugar levels, medical history, and response to the medication. Dosage may be adjusted over time to achieve optimal blood sugar control.
  • Administration: Glipizide is typically taken orally, usually once daily with breakfast or as directed by the healthcare provider. It is essential to follow the prescribed dosing schedule carefully.
  • Monitoring: Regular blood sugar monitoring is essential for individuals taking Glipizide. This helps ensure that blood sugar levels are within the target range and allows for adjustments in medication dosage if needed.
  • Diet and Exercise: Glipizide should be used in conjunction with a healthy diet and regular exercise as part of a comprehensive diabetes management plan. A healthcare provider or a registered dietitian can provide guidance on meal planning and physical activity.
  • Hypoglycemia: Glipizide can lower blood sugar levels, and if the dosage is too high or if it is not taken with food, it may lead to hypoglycemia (low blood sugar). Symptoms of hypoglycemia include shakiness, sweating, rapid heartbeat, confusion, and in severe cases, loss of consciousness. If hypoglycemia occurs, consuming a source of fast-acting carbohydrates (such as fruit juice or glucose tablets) can help raise blood sugar levels quickly.
  • Side Effects and Precautions: It’s important for individuals taking Glipizide to be aware of potential side effects and to discuss any concerns with their healthcare provider. Common side effects may include nausea, diarrhea, and weight gain. Additionally, Glipizide should be used cautiously in people with certain medical conditions, and it may interact with other medications. Always inform your healthcare provider of all the medications you are taking.
  • Regular Follow-Up: Regular check-ups with a healthcare provider are important to monitor the effectiveness of Glipizide and make any necessary adjustments to the treatment plan.

It’s crucial to follow your healthcare provider’s recommendations and instructions regarding Glipizide or any other diabetes medication to effectively manage your blood sugar levels while minimizing potential side effects and complications. Never adjust your medication dosage or stop taking it without consulting your healthcare provider.

Other uses for this medicine

Glipizide is primarily prescribed for the management of high blood sugar levels in people with type 2 diabetes. However, it is not typically used for other medical conditions. The main purpose of Glipizide is to stimulate insulin production and improve insulin sensitivity to lower blood sugar levels in individuals with type 2 diabetes.

What special precautions should I follow?

Regarding special precautions when using Glipizide, here are some important considerations:

  • Allergies: Before taking Glipizide, inform your healthcare provider if you have any allergies, especially if you are allergic to sulfonylurea drugs or any other medications. This is essential to avoid potential allergic reactions.
  • Medical History: Provide your healthcare provider with a complete medical history, including any previous or current medical conditions. Special attention should be given to kidney or liver problems, as these organs play a role in processing and eliminating the medication.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Glipizide with your healthcare provider. Some diabetes medications may not be safe during pregnancy or while breastfeeding, so alternative treatments may be considered.
  • Hypoglycemia: Glipizide can lower blood sugar levels, sometimes leading to hypoglycemia (low blood sugar). Be aware of the symptoms of hypoglycemia, such as shakiness, sweating, rapid heartbeat, confusion, and irritability. Always carry a source of fast-acting carbohydrates, such as glucose tablets or candy, to treat low blood sugar episodes.
  • Alcohol: Alcohol consumption can interact with Glipizide and increase the risk of hypoglycemia. It’s advisable to limit alcohol intake or consult your healthcare provider for guidance on alcohol use while taking this medication.
  • Other Medications: Glipizide can interact with other medications, including prescription and over-the-counter drugs, herbal supplements, and vitamins. Inform your healthcare provider of all the medications and supplements you are taking to ensure there are no potential interactions.
  • Blood Sugar Monitoring: Regularly monitor your blood sugar levels as directed by your healthcare provider. This will help you and your healthcare provider assess the effectiveness of Glipizide and make necessary adjustments to your treatment plan.
  • Dosage Adjustments: Follow the prescribed dosage instructions carefully. Do not change your dose or stop taking Glipizide without consulting your healthcare provider. Dosage adjustments may be necessary over time.
  • Lifestyle Changes: Continue to follow a healthy diet and exercise plan as recommended by your healthcare provider. These lifestyle changes are an essential part of managing diabetes.
  • Emergency Information: Make sure your family members or close contacts are aware of your diabetes and know how to respond in case of severe hypoglycemia or other emergencies.

Always communicate openly with your healthcare provider about any concerns or side effects you may experience while taking Glipizide. They can provide you with personalized guidance and ensure that your diabetes management plan is safe and effective for your specific situation.

What special dietary instructions should I follow?

Special Dietary Instructions for Glipizide:

  • It’s essential to follow a balanced diet as recommended by your healthcare provider or a registered dietitian when taking Glipizide.
  • Pay attention to carbohydrate intake, as Glipizide works by increasing insulin production and may lower blood sugar levels in response to carbohydrates. Consistent carbohydrate intake can help stabilize blood sugar levels.
  • Try to avoid excessive consumption of foods high in sugar, as they can lead to rapid spikes in blood sugar levels.
  • Include a variety of whole grains, vegetables, lean proteins, and healthy fats in your meals to maintain stable blood sugar levels.
  • Monitor your portion sizes and meal timing, and try to eat regular, evenly spaced meals to avoid large fluctuations in blood sugar levels.

What should I do if I forget a dose?

Regarding what to do if you forget a dose of Glipizide:

  • If you forget to take a dose of Glipizide, take it as soon as you remember, unless it is close to the time for your next scheduled dose. If it’s almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
  • Do not take a double dose to make up for the missed one, as this can increase the risk of hypoglycemia. If you’re uncertain about how to handle a missed dose or if you have missed multiple doses, it’s essential to contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Glipizide, like any medication, can cause side effects in some individuals. It’s important to note that not everyone will experience side effects, and the severity of side effects can vary from person to person. Common side effects of Glipizide may include:

  • Hypoglycemia (Low Blood Sugar): This is the most common side effect of Glipizide. It can occur if the medication lowers blood sugar levels too much. Symptoms of hypoglycemia may include shakiness, sweating, rapid heartbeat, confusion, irritability, headache, and in severe cases, loss of consciousness. It’s important to be aware of these symptoms and take steps to treat low blood sugar promptly, such as consuming a source of fast-acting carbohydrates (e.g., fruit juice, glucose tablets).
  • Gastrointestinal Upset: Some people may experience gastrointestinal symptoms like nausea, diarrhea, or stomach discomfort when taking Glipizide.
  • Weight Gain: Weight gain can be a side effect of Glipizide, although not everyone will experience this. It’s important to maintain a healthy diet and engage in regular physical activity to manage weight while taking this medication.
  • Skin Reactions: Rarely, Glipizide may cause skin reactions such as rash or itching.
  • Sensitivity to Sunlight: In some cases, Glipizide can make the skin more sensitive to sunlight, increasing the risk of sunburn.
  • Liver Enzyme Abnormalities: Glipizide may affect liver function, leading to elevated liver enzyme levels. This is typically monitored through blood tests.
  • Allergic Reactions: While rare, allergic reactions to Glipizide can occur. Symptoms of an allergic reaction may include hives, itching, swelling of the face, lips, or tongue, and difficulty breathing. Seek immediate medical attention if you experience any of these symptoms.
  • Other Rare Side Effects: In very rare cases, Glipizide may be associated with more serious side effects, such as blood disorders or jaundice (yellowing of the skin and eyes). These side effects are uncommon but should be reported to a healthcare provider if they occur.

It’s essential to communicate any side effects or concerns with your healthcare provider. They can assess the severity of side effects, adjust your medication if necessary, or recommend alternative treatments. Additionally, your healthcare provider can provide guidance on how to minimize the risk of hypoglycemia and manage any other side effects effectively.

Remember that the benefits of Glipizide in controlling blood sugar levels often outweigh the potential side effects. However, individual responses to medications can vary, so it’s crucial to work closely with your healthcare team to ensure that Glipizide is the right choice for your diabetes management and that any side effects are properly managed.

What should I know about storage and disposal of this medication?


  • Room Temperature: Store Glipizide at room temperature, typically between 68°F to 77°F (20°C to 25°C).
  • Protect from Moisture: Keep the medication in its original container and protect it from moisture and humidity. Avoid storing it in the bathroom.
  • Keep Out of Reach: Keep Glipizide out of the reach of children and pets to prevent accidental ingestion.
  • Do Not Freeze: Do not freeze the medication.


  • Follow Local Regulations: Check with your local pharmacy or healthcare provider for guidance on how to properly dispose of unused or expired Glipizide tablets. Different regions may have specific regulations for medication disposal.
  • Do Not Flush: Do not flush Glipizide down the toilet or pour it into a drain unless instructed to do so by local disposal guidelines.
  • Medication Take-Back Programs: Many communities have medication take-back programs or special disposal sites where you can safely dispose of unused medications. These programs help prevent environmental contamination and accidental ingestion.

In case of emergency/overdose

In case of an emergency or suspected overdose with Glipizide, take the following steps:

  • Contact Emergency Services: Call 911 (or your local emergency number) immediately for medical assistance if someone is experiencing severe symptoms.
  • Poison Control: If you suspect an overdose but the person is conscious and alert, you can also contact your local poison control center or the national poison helpline at 1-800-222-1222 (United States) for guidance.
  • Symptoms: Overdose symptoms may include severe hypoglycemia (very low blood sugar), which can manifest as confusion, seizures, loss of consciousness, and potentially life-threatening complications. Emergency medical treatment is crucial to address low blood sugar in an overdose situation.

What other information should I know

  • Regular Monitoring: Regularly monitor your blood sugar levels as advised by your healthcare provider to ensure that Glipizide is effectively managing your diabetes.
  • Medication Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Glipizide can interact with other drugs. Certain medications can either enhance or diminish the effects of Glipizide, potentially affecting your blood sugar control.
  • Lifestyle Factors: Continue to follow a healthy diet and exercise plan as recommended by your healthcare provider. These lifestyle changes play a significant role in diabetes management.
  • Follow Instructions: Always take Glipizide exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your healthcare team.
  • Regular Check-Ups: Attend regular follow-up appointments with your healthcare provider to monitor your diabetes management and discuss any concerns or side effects.
  • Medical Alert: If you experience severe hypoglycemia or have a history of severe episodes, consider wearing a medical alert bracelet or necklace that indicates your condition to alert healthcare professionals in case of emergency.
  • Dietary Changes: Consult with a registered dietitian or nutritionist for dietary guidance tailored to your diabetes management plan.

Remember that Glipizide is just one component of a comprehensive diabetes management plan. It should be used in conjunction with lifestyle modifications, regular blood sugar monitoring, and guidance from your healthcare provider to achieve optimal results and minimize potential risks.

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