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Mestinon Timespan (Generic Pyridostigmine)

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Why is this medication prescribed?

Mestinon Timespan is a brand name for a medication called Pyridostigmine extended-release tablets. It is primarily prescribed to treat a condition called myasthenia gravis. Myasthenia gravis is an autoimmune disorder that affects the neuromuscular junction, leading to muscle weakness and fatigue. Pyridostigmine, the active ingredient in Mestinon Timespan, works by increasing the levels of a neurotransmitter called acetylcholine in the body. Acetylcholine is necessary for proper muscle function, and Mestinon Timespan helps improve muscle strength and control in individuals with myasthenia gravis.

How should this medicine be used?

Here are some general guidelines on how Mestinon Timespan should be used, but it’s essential to follow your doctor’s specific instructions:

  • Dosage: The dosage of Mestinon Timespan can vary depending on the severity of your myasthenia gravis and your individual response to the medication. Your doctor will prescribe the appropriate dose for you.
  • Timing: Mestinon Timespan is usually taken on an empty stomach, at least 30 minutes before or 2 hours after meals. This helps ensure optimal absorption of the medication.
  • Extended-Release: Mestinon Timespan is an extended-release tablet, which means it releases the medication slowly over time. This allows for more stable and prolonged control of muscle function. It is typically taken once or twice daily, as prescribed by your doctor.
  • Follow Instructions: Follow your doctor’s instructions carefully. Do not change the dosage or frequency of use without consulting your healthcare provider.
  • Do Not Crush or Chew: Swallow the tablets whole with a glass of water. Do not crush or chew them, as this may affect the extended-release properties of the medication.
  • Monitoring: Your doctor may periodically adjust your dosage based on your symptoms and response to treatment. Regular check-ups and communication with your healthcare provider are essential.
  • Side Effects: Like all medications, Mestinon Timespan can have side effects. Common side effects may include stomach upset, diarrhea, increased saliva, and sweating. If you experience severe or unusual side effects, contact your doctor.
  • Missed Dose: If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
  • Precautions: Inform your doctor of any other medications you are taking, as well as any underlying health conditions you have. Some medications and medical conditions may interact with Mestinon Timespan.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Mestinon Timespan with your healthcare provider.

It’s crucial to work closely with your healthcare team when taking Mestinon Timespan to manage your myasthenia gravis effectively and minimize potential side effects or complications. Always consult your doctor or pharmacist if you have any questions or concerns about your medication.

Other uses for this medicine

Mestinon Timespan is primarily used to treat myasthenia gravis and related neuromuscular conditions. However, in some cases, it may be prescribed for off-label uses, which means uses that are not specifically approved by regulatory authorities but have shown promise in clinical practice. Some off-label uses may include:

  • Orthostatic Hypotension: Mestinon may be used to manage orthostatic hypotension (a drop in blood pressure upon standing) in certain cases.
  • Postural Tachycardia Syndrome (POTS): Mestinon may be prescribed off-label to help manage symptoms of POTS, a condition characterized by an abnormal increase in heart rate when moving from a lying down to an upright position.
  • Neuromuscular Disorders: It may be used in other neuromuscular disorders or conditions where improving nerve-to-muscle communication is beneficial.

What special precautions should I follow?

Regarding special precautions for Mestinon Timespan:

  • Allergies: Inform your doctor if you are allergic to pyridostigmine or any other ingredients in Mestinon Timespan. Allergic reactions can be severe and require immediate medical attention.
  • Medical History: Share your complete medical history with your healthcare provider, especially if you have a history of asthma, epilepsy, bradycardia (slow heart rate), or other heart conditions.
  • Other Medications: Notify your doctor about all medications, supplements, or herbal products you are taking, as some drugs can interact with Mestinon Timespan. This includes over-the-counter medicines.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Mestinon Timespan with your healthcare provider. It may be necessary to adjust your treatment plan during these times.
  • Driving and Operating Machinery: Mestinon Timespan can cause dizziness and blurred vision as side effects. If you experience these symptoms, avoid driving or operating heavy machinery until you are sure you can do so safely.
  • Regular Monitoring: Your doctor will likely monitor your progress and may adjust your dosage as needed to achieve the best control of your symptoms while minimizing side effects.
  • Emergency Care: In case of a myasthenic crisis (a severe exacerbation of muscle weakness), it’s crucial to have an emergency plan in place. Your healthcare provider can provide guidance on managing such situations.

Always follow your doctor’s instructions and communicate any concerns or side effects promptly. Mestinon Timespan should be used under the close supervision of a healthcare professional, especially if it is used for off-label purposes or in combination with other medications.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Mestinon Timespan. However, you may want to consider the following:

  • Balanced diet: Maintain a well-balanced diet with a variety of foods to ensure you are getting all the necessary nutrients. This can help support your overall health and well-being, which is important when managing a chronic condition.
  • Hydration: Ensure you stay well-hydrated, as dehydration can sometimes worsen the side effects of certain medications.
  • Consult your doctor or a dietitian: If you have specific dietary concerns or restrictions due to other health conditions, it’s a good idea to consult your healthcare provider or a registered dietitian for personalized guidance.

What should I do if I forget a dose?

If you forget to take a dose of Mestinon Timespan, follow these general guidelines:

  • Take It as Soon as You Remember: If you realize you missed a dose and it’s not too close to your next scheduled dose, take it as soon as you remember.
  • Don’t Double Up: Do not take a double dose to make up for the missed one. Taking too much of this medication at once can increase the risk of side effects.
  • Resume Your Regular Schedule: Continue with your regular dosing schedule from the next dose onward.

What side effects can this medication cause?

Mestinon Timespan (Pyridostigmine extended-release) can cause side effects, like many medications. Not everyone will experience these side effects, and some individuals may experience them to a greater or lesser degree. Common side effects of Mestinon Timespan may include:

  • Stomach Upset: This can include nausea, vomiting, abdominal cramps, and diarrhea. Taking the medication with food or milk may help alleviate these symptoms.
  • Increased Salivation: Some people may notice excessive saliva production or drooling.
  • Sweating: Increased sweating is a possible side effect.
  • Muscle Twitching: You may experience muscle twitching, particularly in the face or fingers.
  • Frequent Urination: Some individuals may notice an increase in urinary frequency.
  • Muscle Cramps: Muscle cramps or spasms can occur in some cases.
  • Dizziness or Lightheadedness: This can happen, especially when standing up quickly.
  • Blurred Vision: You may experience blurred or double vision.
  • Headache: Headaches are a less common side effect.
  • Difficulty Swallowing: Some people may have difficulty swallowing, known as dysphagia.
  • Slurred Speech: Speech may become slurred in some cases.
  • Weakness or Fatigue: While Mestinon is intended to help with muscle weakness, some individuals may experience fatigue as a side effect.
  • Irregular Heartbeat: Rarely, Mestinon can cause heart rhythm disturbances, especially in high doses or in individuals with certain heart conditions.
  • Allergic Reactions: Although rare, severe allergic reactions to Mestinon can occur. Seek immediate medical attention if you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s important to note that the side effects of Mestinon Timespan can vary from person to person. Some people may experience only a few mild side effects, while others may have more severe or bothersome ones. If you experience any side effects that are concerning or persistent, contact your healthcare provider. They can provide guidance on how to manage these side effects or may adjust your dosage or treatment plan if necessary.

What should I know about storage and disposal of this medication?


  • Store in a Cool, Dry Place: Keep Mestinon Timespan at room temperature in a cool, dry place, away from direct sunlight, moisture, and heat. Avoid storing it in the bathroom.
  • Childproof Container: Keep the medication in its original child-resistant container, out of the reach of children and pets.
  • Do Not Transfer: Do not transfer Mestinon Timespan to another container unless instructed to do so by your pharmacist. The original packaging helps protect the medication from light and moisture.


  • Dispose of Unused Medication Properly: If you have any unused or expired Mestinon Timespan tablets, do not flush them down the toilet or throw them in the trash. Properly dispose of them following your local regulations for medication disposal.
  • Take-Back Programs: Some communities have medication take-back programs or events where you can safely dispose of unused medications. Check with your local pharmacy or healthcare facility for information on such programs.

In case of emergency/overdose

In case of an emergency or suspected overdose of Mestinon Timespan, take the following steps:

  • Seek Immediate Medical Attention: Call 911 or your local emergency number immediately if you or someone you know has taken too much Mestinon Timespan or is experiencing severe symptoms.
  • Symptoms of Overdose: Symptoms of an overdose may include severe muscle weakness, difficulty breathing, slurred speech, blurred vision, severe stomach cramps, and more. Prompt medical attention is essential.
  • Do Not Induce Vomiting: Do not try to induce vomiting unless instructed to do so by a healthcare professional.

What other information should I know

  • Follow Instructions Carefully: Take Mestinon Timespan exactly as prescribed by your healthcare provider. Do not change your dosage or stop taking the medication without consulting your doctor.
  • Regular Monitoring: Your healthcare provider may schedule regular check-ups to monitor your condition and adjust your treatment as needed.
  • Communication: Keep open communication with your healthcare provider regarding any side effects, changes in your condition, or concerns you may have while taking Mestinon Timespan.
  • Medication List: Maintain a list of all the medications you are taking, including Mestinon Timespan, and share it with your healthcare providers to help prevent potential drug interactions.
  • Medical Alert Bracelet: In some cases, individuals with myasthenia gravis may wear a medical alert bracelet or necklace indicating their condition and medications. This can be helpful in case of emergencies.
  • Travel: If you plan to travel, especially internationally, make sure you have an adequate supply of Mestinon Timespan and carry your medication in its original container to avoid any issues with customs or security checks.
  • Inform Other Healthcare Providers: If you see different healthcare providers for various conditions, make sure they are aware of your use of Mestinon Timespan to avoid any potential interactions with other medications or treatments.

Always follow your healthcare provider’s guidance and recommendations regarding the use of Mestinon Timespan and any other aspects of your treatment plan. If you have specific questions or concerns about your medication, don’t hesitate to reach out to your healthcare provider or pharmacist for clarification and assistance.

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