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Meropenem and Vaborbactam Injection

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Why is this medication prescribed?

Meropenem and Vaborbactam Injection is a medication prescribed for the treatment of certain serious bacterial infections in adults. It is a combination of two active ingredients: meropenem, which is a broad-spectrum antibiotic, and vaborbactam, which is a beta-lactamase inhibitor. This combination is used to treat infections caused by bacteria that are resistant to many other antibiotics due to the production of beta-lactamase enzymes.

Common indications for prescribing Meropenem and Vaborbactam Injection include:

  • Complicated urinary tract infections (cUTI): This includes infections involving the kidneys, bladder, and surrounding structures.
  • Complicated intra-abdominal infections (cIAI): These are serious infections within the abdominal cavity, often involving multiple organs or structures.
  • Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP): These are respiratory infections that occur in hospitalized patients on mechanical ventilation.

How should this medicine be used?

The dosing and administration of Meropenem and Vaborbactam Injection can vary depending on the specific infection being treated, the patient’s weight and renal function, and other factors. It is typically administered by a healthcare professional as an intravenous (IV) infusion. The healthcare provider will determine the appropriate dosage and duration of treatment based on the individual patient’s condition.

It’s crucial to follow your healthcare provider’s instructions and complete the full course of treatment, even if you start feeling better before the medication is finished. Stopping the medication prematurely could lead to the development of antibiotic resistance and a potential resurgence of the infection.

As with any medication, Meropenem and Vaborbactam Injection can have side effects and potential interactions with other drugs. It’s essential to discuss your medical history, allergies, and current medications with your healthcare provider before starting this treatment. They will monitor your progress and adjust the treatment plan as needed to ensure the best possible outcome while minimizing side effects and risks.

Other uses for this medicine

Meropenem and Vaborbactam Injection is primarily used for the treatment of specific bacterial infections, as mentioned in the previous response. It is specifically designed to combat infections caused by certain multidrug-resistant bacteria, particularly those producing beta-lactamase enzymes. Using this medication for purposes other than those prescribed by your healthcare provider is not recommended. Only take this medication under the guidance and supervision of a qualified healthcare professional.

What special precautions should I follow?

Special precautions and considerations for Meropenem and Vaborbactam Injection include:

  • Allergies: Inform your healthcare provider about any allergies you have, especially if you are allergic to meropenem, vaborbactam, or any other beta-lactam antibiotics (e.g., penicillins, cephalosporins). Allergic reactions can be severe and require immediate medical attention.
  • Renal Function: Your kidney function should be assessed before and during treatment with Meropenem and Vaborbactam Injection, as the dosing may need adjustment in patients with impaired renal function. The drug is primarily eliminated through the kidneys, so individuals with kidney problems may require a modified dosing regimen.
  • Neurological Side Effects: Some patients may experience neurological side effects such as seizures when taking meropenem. If you have a history of seizures or neurological conditions, discuss this with your healthcare provider before starting the medication.
  • Superinfection: Long-term or repeated use of antibiotics, including Meropenem and Vaborbactam Injection, can result in an overgrowth of non-susceptible bacteria or fungi. If you develop new infections during or after treatment, notify your healthcare provider.
  • Pregnancy and Breastfeeding: Discuss the use of this medication with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The potential risks and benefits will need to be evaluated on an individual basis.
  • Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are currently taking. Meropenem and Vaborbactam Injection can interact with other drugs, potentially affecting their effectiveness or increasing the risk of side effects.
  • Monitoring: Your healthcare provider will closely monitor your condition while you are receiving Meropenem and Vaborbactam Injection. This includes checking for signs of improvement and assessing for any adverse effects.
  • Completing the Course: Finish the full course of treatment as prescribed by your healthcare provider, even if your symptoms improve before the medication is completed. Stopping the treatment prematurely may lead to antibiotic resistance and the return of the infection.

Always follow your healthcare provider’s instructions and communicate any concerns or questions you may have about Meropenem and Vaborbactam Injection. Your healthcare provider will tailor your treatment plan to ensure the best possible outcome while minimizing potential risks and side effects.

What special dietary instructions should I follow?

There are no specific dietary restrictions or instructions that are typically associated with taking Meropenem and Vaborbactam Injection. However, it’s essential to follow your healthcare provider’s guidance on the timing of your doses and whether you should take the medication with or without food. This can vary depending on the specific treatment plan and the type of infection being treated.

What should I do if I forget a dose?

If you forget a dose of Meropenem and Vaborbactam Injection, follow these general guidelines:

  • As Soon as Possible: If you realize that you missed a dose shortly after the scheduled time, take it as soon as you remember. However, if it’s close to the time for your next dose, skip the missed dose and proceed with your regular dosing schedule.
  • Don’t Double Dose: Never take a double dose to make up for the missed one. Taking more than the prescribed amount can increase the risk of side effects and complications.
  • Notify Your Healthcare Provider: It’s a good practice to inform your healthcare provider about the missed dose so they can provide guidance on how to proceed. They may need to adjust your dosing schedule or make other recommendations based on your specific situation.

What side effects can this medication cause?

Meropenem and Vaborbactam Injection is a combination medication used to treat certain bacterial infections. Like all medications, it can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience them to a greater or lesser degree. If you have been prescribed Meropenem and Vaborbactam Injection, it’s essential to discuss potential side effects and concerns with your healthcare provider, as they can provide guidance based on your specific medical history and condition.

Common side effects of Meropenem and Vaborbactam Injection may include:

  • Nausea and vomiting
  • Diarrhea
  • Headache
  • Rash or itching
  • Pain, redness, or swelling at the injection site
  • Changes in laboratory test results (e.g., liver function tests, kidney function tests)

Less common but more serious side effects can also occur. If you experience any of the following, seek immediate medical attention:

  • Allergic reactions, such as hives, itching, swelling of the face, lips, tongue, or throat, difficulty breathing, or severe dizziness
  • Severe diarrhea that may be watery or bloody
  • Seizures
  • Unusual tiredness or weakness
  • Dark urine or yellowing of the skin or eyes (signs of liver problems)
  • Unusual bruising or bleeding (signs of a decrease in blood platelets)
  • Severe skin reactions, such as blistering, peeling, or a rash with fever
  • Signs of kidney problems, such as decreased urine output, swelling in the ankles or feet, or unusual tiredness

These are not all the possible side effects of Meropenem and Vaborbactam Injection. Some people may experience side effects not listed here. If you have concerns about side effects or notice any unusual symptoms while taking this medication, contact your healthcare provider promptly.

It’s important to follow your healthcare provider’s instructions carefully when using Meropenem and Vaborbactam Injection and report any side effects or adverse reactions promptly to ensure your safety and effective treatment.

What should I know about storage and disposal of this medication?


  • Proper Storage: Store Meropenem and Vaborbactam Injection as directed by your healthcare provider or pharmacist. Typically, it is stored at room temperature (20-25°C or 68-77°F). However, specific storage instructions may vary depending on the manufacturer and formulation, so always follow the label on the medication packaging.
  • Protect from Light: Some formulations may require protection from light. If so, keep the medication in its original packaging or container to shield it from light exposure.
  • Do Not Freeze: Do not freeze the medication, as it may become less effective if frozen.
  • Keep Out of Reach of Children: Store Meropenem and Vaborbactam Injection in a location that is out of the reach of children and pets.


Do not dispose of Meropenem and Vaborbactam Injection in household trash or wastewater. Follow local regulations for the proper disposal of unused or expired medications. You can ask your healthcare provider or pharmacist for guidance on safe disposal methods.

In case of emergency/overdose

In the event of an emergency or suspected overdose of Meropenem and Vaborbactam Injection, seek immediate medical attention or contact a poison control center. Overdose symptoms may include severe nausea, vomiting, diarrhea, or neurological symptoms like seizures.

What other information should I know

  • Complete the Full Course: Finish the entire prescribed course of Meropenem and Vaborbactam Injection, even if you start feeling better before the medication is finished. Stopping the treatment prematurely may result in the recurrence of the infection.
  • Follow Healthcare Provider’s Instructions: Always follow your healthcare provider’s instructions regarding the dosage, frequency, and duration of treatment. If you have any questions or concerns about the medication, discuss them with your healthcare provider or pharmacist.
  • Antibiotic Resistance: The overuse or misuse of antibiotics can lead to antibiotic resistance. Use Meropenem and Vaborbactam Injection only as prescribed and only for the indicated infection. Do not share antibiotics with others, and do not use leftover antibiotics for future illnesses.
  • Inform Healthcare Provider: Keep your healthcare provider informed of any new symptoms, side effects, or changes in your condition while taking Meropenem and Vaborbactam Injection.
  • Allergies and Medication History: Ensure your healthcare provider is aware of your complete medical history, including any allergies and previous adverse reactions to medications.
  • Regular Check-ups: Attend any follow-up appointments scheduled by your healthcare provider to monitor your progress and ensure that the treatment is effective.

Always consult your healthcare provider or pharmacist if you have specific questions or concerns about Meropenem and Vaborbactam Injection, its storage, or any other aspects of your treatment. They can provide you with personalized guidance based on your medical history and current health status.

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