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Mepolizumab Injection

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Why is this medication prescribed?

Mepolizumab is a prescription medication used to treat certain types of severe asthma and a condition called eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome. It is typically prescribed by a healthcare provider and administered by injection.

  • Prescribed for Severe Asthma: Mepolizumab is often prescribed for individuals with severe asthma that is characterized by frequent exacerbations and symptoms that are not well-controlled with standard asthma medications such as inhaled corticosteroids and long-acting beta-agonists. It is particularly beneficial for those with eosinophilic asthma, a type of asthma characterized by high levels of eosinophils (a type of white blood cell) in the blood and airways.
  • Prescribed for EGPA: Mepolizumab is also used in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA), a rare autoimmune disease that can affect various organs in the body, including the lungs, skin, and nerves. This condition is characterized by high levels of eosinophils and inflammation in the blood vessels.

How should this medicine be used?

Mepolizumab is typically administered as a subcutaneous (under the skin) injection. Here are some general guidelines on how it should be used:

  • Dosage: The specific dosage and frequency of Mepolizumab injections will be determined by your healthcare provider based on your condition and medical history.
  • Administration: Mepolizumab is usually self-administered by the patient or a caregiver at home. Your healthcare provider will provide detailed instructions on how to properly prepare and administer the injection. It is important to follow these instructions carefully.
  • Injection Site: Mepolizumab is injected into the thigh or abdomen. Your healthcare provider will provide guidance on where to inject.
  • Rotating Injection Sites: It is important to rotate the injection site with each dose to minimize the risk of skin irritation or injection site reactions.
  • Storage: Store Mepolizumab as directed by your healthcare provider or the medication’s packaging. Typically, it should be kept in the refrigerator at a specific temperature range, but some formulations may be stored at room temperature for a limited time.
  • Monitoring: Your healthcare provider may monitor your condition and adjust the dosage as needed to ensure optimal control of your asthma or EGPA.
  • Adherence: It is crucial to adhere to the prescribed dosing schedule and not miss any injections unless directed otherwise by your healthcare provider.

As with any medication, it’s important to discuss the potential benefits and risks of Mepolizumab with your healthcare provider. They can provide personalized guidance on its use, and you should report any side effects or concerns promptly to your healthcare team.

Other uses for this medicine

Mepolizumab is primarily prescribed for the treatment of severe asthma and eosinophilic granulomatosis with polyangiitis (EGPA). It is a targeted therapy designed to reduce eosinophil levels and control inflammation associated with these conditions. While it is not typically used for other purposes, it’s essential to consult your healthcare provider for guidance on its use and to discuss any potential off-label uses.

What special precautions should I follow?

Regarding special precautions for Mepolizumab Injection, here are some important considerations:

  • Allergies: Inform your healthcare provider about any allergies you have, especially if you are allergic to Mepolizumab or any of its ingredients. Allergic reactions to medications can be severe and require immediate medical attention.
  • Infections: Mepolizumab may increase your risk of infections. Before starting treatment, discuss any existing infections or recent illnesses with your healthcare provider. If you develop signs of an infection (such as fever, cough, or sore throat), contact your healthcare provider promptly.
  • Vaccinations: It is essential to stay up-to-date on vaccinations, including the annual flu vaccine, while on Mepolizumab. However, live vaccines should be avoided during treatment, as they may pose a risk of infection.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Mepolizumab with your healthcare provider. The safety of Mepolizumab during pregnancy and breastfeeding is not well-established, so decisions should be made on a case-by-case basis.
  • Medical Conditions: Inform your healthcare provider of any other medical conditions you have, including ongoing or past infections, immunodeficiency disorders, or any other chronic illnesses. These conditions may influence the decision to use Mepolizumab.
  • Medication Interactions: Discuss all medications, supplements, or herbal products you are taking with your healthcare provider. Certain medications may interact with Mepolizumab and need to be adjusted or discontinued.
  • Monitoring: Your healthcare provider may monitor your condition closely while you are receiving Mepolizumab. This may include regular blood tests and assessments to evaluate your response to treatment and any potential side effects.
  • Injection Site Reactions: Pay attention to the injection site after each dose of Mepolizumab. If you experience any signs of irritation, redness, swelling, or itching at the injection site, report it to your healthcare provider.
  • Emergency Plan: If you have asthma, make sure you have an asthma action plan in place, including the use of rescue medications, in case of exacerbations.
  • Follow Instructions: Always follow your healthcare provider’s instructions for the administration of Mepolizumab and the dosing schedule. Do not change the dose or frequency without consulting your healthcare provider.

It’s crucial to maintain open communication with your healthcare provider throughout your Mepolizumab treatment. They can provide guidance, address any concerns, and monitor your progress to ensure that you are receiving the most appropriate and effective care for your specific condition.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with mepolizumab injections. However, it’s essential to maintain a healthy and balanced diet to support your overall well-being. If you have specific dietary concerns or questions, consult your healthcare provider or a registered dietitian for guidance.

What should I do if I forget a dose?

If you forget a dose of mepolizumab, contact your healthcare provider or nurse as soon as possible to discuss the missed dose and receive further instructions. It’s important not to double up on doses to make up for a missed one. Your healthcare provider will provide guidance on how to proceed.

What side effects can this medication cause?

Mepolizumab injection is generally well-tolerated, but like any medication, it can cause side effects in some individuals. Not everyone will experience these side effects, and the severity can vary from person to person. Common side effects of Mepolizumab may include:

  • Headache: Mild to moderate headaches are one of the more common side effects reported with Mepolizumab.
  • Injection Site Reactions: Some people may experience mild redness, swelling, or itching at the injection site. These reactions are usually not serious and tend to improve on their own.
  • Back Pain: Back pain is another relatively common side effect of Mepolizumab.
  • Fatigue: Some individuals may experience fatigue or tiredness.
  • Upper Respiratory Tract Infections: In clinical trials, upper respiratory tract infections (such as the common cold) have been reported in some patients.

It’s important to note that these side effects are not experienced by everyone, and many people tolerate Mepolizumab well without significant issues. Additionally, side effects are typically mild to moderate in intensity.

While less common, there are also some potential serious side effects associated with Mepolizumab, although these are rare. These can include:

  • Allergic Reactions: Severe allergic reactions to Mepolizumab are rare but can occur. Seek immediate medical attention if you experience symptoms such as difficulty breathing, swelling of the face, lips, tongue, or throat, or severe itching.
  • Parasitic Infections: In rare cases, individuals treated with Mepolizumab may develop parasitic infections. Be vigilant for symptoms such as stomach pain, diarrhea, weight loss, or skin rashes, and promptly report any concerning symptoms to your healthcare provider.
  • Reduction in Blood Eosinophil Levels: Mepolizumab works by reducing eosinophils, which are a type of white blood cell. In some cases, this reduction can be excessive, leading to a decreased ability to fight certain infections. Your healthcare provider will monitor your blood eosinophil levels and adjust your treatment as necessary.

It’s essential to communicate any side effects or unusual symptoms to your healthcare provider promptly. They can help assess whether any side effects are a cause for concern and make any necessary adjustments to your treatment plan.

Please note that the information provided here is not exhaustive, and the side effects of Mepolizumab may vary among individuals. Your healthcare provider will provide you with more detailed information about the potential side effects and how to manage them based on your specific medical history and treatment plan.

What should I know about storage and disposal of this medication?


  • Refrigeration: Mepolizumab injections typically require refrigeration to maintain their stability. Follow the storage instructions provided by your healthcare provider or on the medication packaging. Store the medication at the recommended temperature range.
  • Do Not Freeze: Do not freeze Mepolizumab. If it freezes, it should not be used.
  • Protection from Light: Some formulations may be light-sensitive. Ensure that the medication is protected from direct light.
  • Keep Out of Reach of Children: Store Mepolizumab out of the reach of children and pets.


  • Dispose of Sharps Safely: Mepolizumab injections involve the use of needles and syringes. After use, dispose of the used needles and syringes in a sharps container or another appropriate container designed for safe disposal of medical sharps.
  • Follow Local Regulations: Follow your local regulations for disposing of medication containers, such as vials, packaging, or unused portions of the medication. Some areas may have specific guidelines for disposing of medications and their containers.

In case of emergency or suspicion of an overdose, take the following steps:

In the event of an emergency or suspected overdose of Mepolizumab Injection, take the following steps:

  • Seek Medical Help: If you suspect an overdose or experience severe allergic reactions (anaphylaxis) characterized by symptoms like difficulty breathing, swelling of the face, lips, tongue, or throat, or severe itching, seek immediate medical attention or call emergency services.
  • Poison Control Center: In the United States, you can contact the Poison Control Center at 1-800-222-1222 for guidance on overdose situations. Have all relevant information, including the medication name and dosage, available when calling.

What other information should I know

  • Follow Instructions: Always follow your healthcare provider’s instructions for the administration of Mepolizumab, including the dosing schedule and any specific guidance for self-injection.
  • Monitoring: Your healthcare provider may monitor your condition, including blood eosinophil levels and overall response to treatment. Attend all recommended follow-up appointments.
  • Medication Interactions: Inform your healthcare provider about all medications, supplements, or herbal products you are taking, as Mepolizumab may interact with certain medications.
  • Vaccinations: Stay up-to-date on vaccinations as recommended by your healthcare provider. Discuss any vaccination concerns with your healthcare team.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Mepolizumab with your healthcare provider to weigh the potential risks and benefits.
  • Travel: If you plan to travel with Mepolizumab, consult your healthcare provider for guidance on how to store and transport the medication safely.

Always keep your healthcare provider informed about any changes in your health, including new symptoms or any side effects you may experience while taking Mepolizumab. They can provide personalized guidance and adjust your treatment plan as needed to ensure the best possible care for your condition.

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