PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Menostar (Generic Estradiol Transdermal Patch)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Menostar is a medication primarily prescribed to postmenopausal women to relieve symptoms associated with menopause, such as hot flashes and vaginal discomfort. It contains a form of estrogen called estradiol, which is absorbed through the skin via a patch. While Menostar can be effective in managing menopausal symptoms, it also carries certain risks and potential side effects that should be considered:

  • Increased Risk of Blood Clots: Estrogen-containing medications like Menostar may slightly elevate the risk of blood clots, which can lead to serious conditions like deep vein thrombosis (DVT) or pulmonary embolism. This risk is higher in women with a history of blood clots.
  • Increased Risk of Stroke: There is a small increase in the risk of stroke associated with estrogen therapy. Women with a history of stroke or other risk factors for stroke should carefully consider this risk.
  • Breast Cancer: Some studies have suggested a slightly elevated risk of breast cancer with long-term use of estrogen replacement therapy. Women should discuss their breast cancer risk with their healthcare provider.
  • Uterine Cancer: Women with an intact uterus who take estrogen without a progestin (another hormone) are at an increased risk of developing uterine cancer. Adding a progestin may help offset this risk.
  • Cardiovascular Disease: Estrogen therapy may have different effects on cardiovascular health depending on a woman’s age and overall health. It’s essential to discuss your individual cardiovascular risk factors with your healthcare provider.
  • Gallbladder Disease: Estrogen therapy can increase the risk of gallbladder disease, including gallstones.
  • Side Effects: Menostar can cause side effects such as skin irritation at the patch application site, breast tenderness, nausea, and headache.
  • Interactions: Menostar may interact with other medications you are taking, so it’s crucial to inform your healthcare provider of all the drugs you are using.
  • Not for Everyone: Menostar is not suitable for all women. It’s generally recommended for women who have moderate to severe menopausal symptoms and have discussed the potential benefits and risks with their healthcare provider.
  • Regular Monitoring: Women who use Menostar should have regular check-ups with their healthcare provider to monitor their response to the medication and assess any potential risks.

It’s important to note that the decision to use Menostar or any hormone replacement therapy should be made in consultation with a healthcare provider who can evaluate your individual health, medical history, and risk factors. They can help you weigh the potential benefits and risks and determine if Menostar is an appropriate treatment for your specific situation.

Why is this medication prescribed?

Menostar is a prescription medication used to treat certain symptoms associated with menopause in women. It contains the active ingredient estradiol, which is a form of the hormone estrogen. Menopause is a natural stage in a woman’s life when her ovaries stop producing eggs and hormone levels, including estrogen, decline. This hormonal shift can lead to various symptoms, including hot flashes, vaginal dryness, and other discomforts.

Menostar is typically prescribed for the following purposes:

  • Hot Flashes: Menostar can help alleviate hot flashes, which are sudden, intense feelings of warmth, often accompanied by sweating and a flushed face.
  • Vaginal Dryness: It can also be prescribed to relieve vaginal dryness, which can cause discomfort and pain during sexual intercourse.
  • Prevention of Osteoporosis: In some cases, Menostar may be used to prevent osteoporosis (thinning of the bones) in postmenopausal women who are at an increased risk for fractures.

The way Menostar is used can vary based on a doctor’s prescription and individual patient needs. It’s important to follow your healthcare provider’s instructions carefully.

How should this medicine be used?

here are some general guidelines for using Menostar:

Dosage: Menostar is available as a transdermal patch. The usual dosage is one patch applied to the lower abdomen once a week. Each patch is worn for 7 days, and then it is replaced with a new one.

Application: Here’s how to apply Menostar:

  • Choose a clean, dry area of the lower abdomen for patch application. Avoid areas with cuts, rashes, or irritations.
  • Open the pouch containing the patch.
  • Remove the protective liner from the patch to expose the adhesive side.
  • Carefully apply the patch to the chosen area of your abdomen, pressing it down firmly to ensure it sticks.
  • The patch is typically worn for 7 days. After a week, remove the old patch and apply a new one to a different area of the abdomen.
  • Continue this weekly application schedule as prescribed by your healthcare provider.

It’s important to follow your doctor’s recommendations regarding the duration of Menostar use. Hormone replacement therapy, including Menostar, is not without risks, and the decision to use it should be made after a thorough discussion of the potential benefits and risks with your healthcare provider. Regular check-ups and follow-up appointments are typically recommended when using Menostar or any hormone replacement therapy to monitor its effectiveness and safety for your specific health needs. If you experience any unusual or severe side effects while using Menostar, consult your healthcare provider promptly.

Other uses for this medicine

Menostar contains estradiol, which is a form of estrogen, and it is primarily prescribed for the treatment of menopausal symptoms and, in some cases, for the prevention of osteoporosis in postmenopausal women. Its use should be guided by a healthcare provider’s prescription and recommendations. While it may have some off-label uses in specific situations, it’s important to understand that using Menostar for conditions other than those approved by healthcare authorities may not be safe or effective. Off-label use should only be considered under the supervision and guidance of a qualified medical professional.

What special precautions should I follow?

As for special precautions when using Menostar, here are some important points to keep in mind:

  • Medical History: Before starting Menostar or any hormone replacement therapy, inform your healthcare provider of your complete medical history, including any past or current medical conditions, allergies, surgeries, and a family history of certain health conditions.
  • Breast Cancer Risk: Women with a history of breast cancer or those at high risk for breast cancer should discuss the potential risks and benefits of Menostar with their healthcare provider. Estrogen therapy may increase the risk of breast cancer in some women.
  • Endometrial Cancer Risk: If you still have your uterus, your healthcare provider may prescribe a progestin in addition to Menostar to reduce the risk of endometrial cancer, which can be associated with estrogen-only therapy in women with a uterus.
  • Cardiovascular Health: Discuss your cardiovascular health with your doctor. Estrogen therapy may affect your risk of heart disease, blood clots, and stroke. Your healthcare provider will evaluate whether Menostar is appropriate for you based on your cardiovascular risk factors.
  • Bone Health: If Menostar is prescribed for osteoporosis prevention, your healthcare provider will assess your bone density and overall bone health to determine the appropriate treatment plan.
  • Regular Check-ups: It’s important to have regular check-ups and follow-up appointments with your healthcare provider while using Menostar to monitor its effectiveness and assess any potential side effects or complications.
  • Side Effects: Be aware of potential side effects of Menostar, which can include breast tenderness, headache, nausea, and changes in vaginal bleeding. If you experience any unusual or severe side effects, contact your healthcare provider.
  • Smoking and Alcohol: Smoking and alcohol consumption may increase the risk of certain side effects associated with Menostar. Discuss your smoking and alcohol habits with your healthcare provider.
  • Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Menostar.
  • Pregnancy and Breastfeeding: Menostar is not intended for use during pregnancy. If you become pregnant while using Menostar, contact your healthcare provider. It’s also important to discuss the use of Menostar if you are breastfeeding.

These precautions are general guidelines, and individual recommendations may vary based on your specific health profile. Always follow your healthcare provider’s instructions and have open and honest discussions about the benefits and risks of using Menostar in your particular situation. Regular follow-up appointments can help ensure that your treatment plan remains appropriate for your needs.

What special dietary instructions should I follow?

  • While using Menostar, there are no specific dietary restrictions that you need to follow. However, maintaining a balanced and healthy diet is essential for overall well-being during menopause.
  • It’s a good idea to include foods rich in calcium and vitamin D in your diet to help maintain bone health. Some sources of these nutrients include dairy products, leafy green vegetables, fortified cereals, and supplements as recommended by your healthcare provider.
  • Limiting alcohol consumption and avoiding smoking is advisable, as these habits can impact your health negatively, especially during menopause.

What should I do if I forget a dose?

  • If you forget to apply a Menostar patch on the scheduled day, apply it as soon as you remember. Then, continue with your regular dosing schedule.
  • If you don’t remember until it’s close to the time for your next scheduled dose, skip the missed dose and apply the new patch at your regular time.
  • Do not apply more than one patch at a time to make up for a missed dose.
  • If you have trouble remembering to apply the patch, consider setting a reminder or using a calendar to help you keep track.

What side effects can this medication cause?

Menostar is a medication that contains estradiol, a form of estrogen, and like all medications, it can potentially cause side effects. Not everyone will experience side effects, and the severity and frequency of side effects can vary from person to person. It’s important to discuss any concerns about potential side effects with your healthcare provider before starting Menostar. Here are some common and less common side effects associated with Menostar:

Common Side Effects:

  • Breast Tenderness: Many women may experience breast tenderness or enlargement while using Menostar.
  • Headache: Headaches are a relatively common side effect.
  • Nausea: Some women may experience mild nausea when using Menostar.
  • Vaginal Bleeding or Spotting: Changes in menstrual bleeding patterns, including spotting or breakthrough bleeding, can occur, especially during the first few months of use.
  • Vaginal Discharge: You may notice changes in vaginal discharge.
  • Skin Irritation: Skin reactions at the site of patch application, such as redness or itching, can occur.
  • Bloating: Some women may experience bloating or fluid retention.

Less Common Side Effects:

  • Mood Changes: Some women may experience mood swings, depression, or changes in mood.
  • Digestive Issues: Gastrointestinal symptoms like stomach cramps, abdominal pain, or changes in bowel habits can occur in some cases.
  • Headaches: Severe or persistent headaches should be reported to your healthcare provider.
  • Vision Changes: Rarely, changes in vision or contact lens intolerance may occur.
  • Breast Changes: In some cases, breast pain or breast lumps may develop.
  • High Blood Pressure: Estrogen therapy can potentially increase blood pressure, and it should be monitored regularly by your healthcare provider.
  • Liver Problems: Estrogen therapy may affect liver function, and liver function tests may be performed periodically.
  • Gallbladder Issues: There may be an increased risk of gallbladder disease.
  • Blood Clots: While the risk is relatively low, estrogen therapy may increase the risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE).
  • Stroke: Estrogen therapy may increase the risk of stroke, particularly in older women and those with other risk factors.
  • Breast Cancer: Long-term use of estrogen therapy may be associated with a slightly increased risk of breast cancer.

It’s important to note that the benefits and risks of Menostar or any estrogen therapy should be carefully weighed by your healthcare provider. Not all women are suitable candidates for estrogen therapy, and the decision to use Menostar should be based on your individual health history, menopausal symptoms, and risk factors. Your healthcare provider can provide guidance on the most appropriate treatment plan for you and monitor your progress while using Menostar to minimize potential side effects and complications. If you experience severe or concerning side effects, contact your healthcare provider promptly.

What should I know about storage and disposal of this medication?


  • Store Menostar patches at room temperature, away from excessive heat or moisture. Avoid storing them in the bathroom.
  • Keep Menostar out of reach of children and pets, as the patches contain medication that should not be ingested.
  • Ensure that the patches are kept in their original pouches until they are ready to be used.


  • Dispose of used Menostar patches as directed by your healthcare provider or pharmacist. They may provide specific instructions for disposal.
  • Do not flush Menostar patches down the toilet, as they may harm the environment.
  • Ask your healthcare provider or pharmacist about any local regulations or guidelines for disposing of medication patches.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms while using Menostar, seek emergency medical attention immediately. Overdose symptoms may include:

  • Severe nausea or vomiting
  • Unusual vaginal bleeding
  • Pain or swelling in the breasts
  • Dizziness or fainting
  • Severe headaches
  • Confusion
  • Visual disturbances
  • Trouble breathing
  • Seizures

It’s important to contact your local poison control center (1-800-222-1222 in the United States) for guidance in the event of an overdose. Be prepared to provide information about the amount of medication involved and any symptoms you or the affected person is experiencing.

What other information should I know

  • Menostar is a prescription medication, and it should only be used under the supervision and guidance of a healthcare provider. Follow the prescribed dosage and schedule.
  • Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to Menostar and to discuss any concerns or side effects.
  • Inform any other healthcare providers, including dentists and surgeons, about your use of Menostar, as it may interact with other medications or affect medical procedures.
  • Report any unusual or severe side effects to your healthcare provider promptly.
  • If you miss a dose, follow your healthcare provider’s instructions for making up the missed dose. Do not use extra patches to compensate for a missed dose.
  • Keep a list of all the medications, supplements, and herbal products you are taking and share it with your healthcare provider to avoid potential drug interactions.
  • Menostar is not intended for use during pregnancy. If you become pregnant while using Menostar, contact your healthcare provider.
  • If you plan to undergo surgery or will be on prolonged bed rest, discuss with your healthcare provider whether you should discontinue Menostar temporarily, as estrogen therapy can increase the risk of blood clots.

Always follow your healthcare provider’s guidance and recommendations for the safe and effective use of Menostar. If you have any questions or concerns about your medication, do not hesitate to reach out to your healthcare provider or pharmacist for clarification and guidance.

Copyright © 2023