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Maxzide (Generic Triamterene and Hydrochlorothiazide)

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Why is this medication prescribed?

Maxzide is a brand name for a medication that combines two active ingredients: hydrochlorothiazide and triamterene. It is prescribed for the treatment of high blood pressure (hypertension) and the reduction of excess fluid retention (edema) in conditions such as congestive heart failure and certain kidney disorders.

  • High Blood Pressure (Hypertension): Maxzide is commonly prescribed to lower high blood pressure. Hydrochlorothiazide is a diuretic that helps the body get rid of excess salt and water, reducing blood volume and ultimately lowering blood pressure. Triamterene, on the other hand, helps prevent the loss of potassium that can occur with hydrochlorothiazide.
  • Edema: Maxzide can also be used to reduce fluid retention (edema) associated with various medical conditions, including congestive heart failure and kidney disorders. It works by increasing the excretion of salt and water from the body, thereby reducing fluid buildup.

How should this medicine be used?

Here are some general guidelines for how Maxzide should be used:

  • Dosage: The specific dosage of Maxzide will depend on your medical condition and your doctor’s recommendations. It is typically taken once daily, preferably in the morning, with or without food.
  • Follow Your Doctor’s Instructions: It’s essential to take Maxzide exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your doctor, even if you start to feel better.
  • Stay Hydrated: While taking Maxzide, it’s important to drink enough fluids unless otherwise directed by your doctor. Diuretics like hydrochlorothiazide can cause increased urination, which may lead to dehydration if not compensated for with increased fluid intake.
  • Potassium Supplements: Depending on your individual medical history, your doctor may recommend potassium supplements or dietary changes to maintain an appropriate balance of potassium in your body. This is because hydrochlorothiazide can cause potassium loss, and triamterene is used to counteract this effect.
  • Regular Check-Ups: You should have regular check-ups with your healthcare provider while taking Maxzide to monitor your blood pressure, potassium levels, and overall health.
  • Possible Side Effects: Like any medication, Maxzide may have side effects. Common side effects can include increased urination, dizziness, headache, and upset stomach. More severe side effects are less common but can include irregular heartbeat, muscle cramps or weakness, and signs of dehydration (e.g., dry mouth, extreme thirst). If you experience any unusual or severe side effects, contact your doctor immediately.

It’s crucial to remember that medication management should always be under the guidance and supervision of a healthcare professional who can tailor the treatment to your specific medical needs and monitor your progress. If you have any questions or concerns about Maxzide or its use, consult with your doctor or pharmacist for more information.

Other uses for this medicine

Maxzide is primarily prescribed to manage high blood pressure and edema. However, in some cases, healthcare providers may use it off-label for other conditions. Off-label uses are determined by your doctor based on their clinical judgment and may include conditions such as:

  • Kidney Stones: Maxzide may be prescribed to help prevent certain types of kidney stones by reducing the amount of calcium in the urine.
  • Hypokalemia: It can also be used to treat low potassium levels (hypokalemia) when other treatments are ineffective.

Please note that using Maxzide for off-label purposes should only be done under the guidance and supervision of a healthcare professional.

What special precautions should I follow?

Special precautions and considerations for Maxzide use include:

  • Allergies: Inform your healthcare provider of any allergies you have, especially if you are allergic to sulfa drugs, as hydrochlorothiazide contains a sulfa component.
  • Kidney Function: Maxzide may not be suitable for individuals with impaired kidney function. Your doctor will assess your kidney function before prescribing this medication.
  • Potassium Levels: Monitoring of potassium levels in the blood is crucial, as Maxzide can affect potassium balance. Your doctor may recommend dietary changes or potassium supplements if needed.
  • Liver Function: Inform your healthcare provider if you have liver disease, as Maxzide may need to be used with caution or avoided in some cases.
  • Pregnancy and Breastfeeding: Maxzide should be used with caution during pregnancy, especially in the first trimester. It may also pass into breast milk, so consult your doctor before using it while breastfeeding.
  • Interactions: Maxzide may interact with other medications you are taking, including other blood pressure medications, non-steroidal anti-inflammatory drugs (NSAIDs), and certain antibiotics. Always inform your doctor and pharmacist about all medications and supplements you are taking.
  • Dehydration: Be cautious about dehydration, especially in hot weather or during physical activity. Ensure you drink enough fluids while taking Maxzide.
  • Blood Pressure Monitoring: Regularly monitor your blood pressure as directed by your doctor.
  • Side Effects: Be aware of potential side effects, such as dizziness or lightheadedness, especially when standing up quickly. Report any unusual or severe side effects to your doctor.

Remember that Maxzide should only be used as prescribed by a healthcare provider, and you should follow their instructions closely. If you have any concerns or questions about Maxzide or its precautions, discuss them with your doctor or pharmacist.

What special dietary instructions should I follow?

Dietary Instructions:

  • Potassium-Rich Foods: Be cautious with potassium-rich foods, as Maxzide can affect potassium levels. Foods high in potassium include bananas, oranges, tomatoes, potatoes, spinach, and certain salt substitutes. Consult your doctor or a dietitian for specific dietary recommendations.
  • Sodium Intake: Maxzide is a diuretic that can cause increased urination. It may be helpful to reduce your sodium intake, as it can help manage blood pressure and fluid retention.
  • Stay Hydrated: Maintaining adequate hydration is important. Ensure you drink enough water throughout the day to prevent dehydration.

What should I do if I forget a dose?

If You Forget a Dose:

  • If you miss a dose of Maxzide, take it as soon as you remember, unless it’s close to the time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule.
  • Do not double up on doses to make up for a missed one.
  • If you frequently forget doses, consider setting an alarm or using a pill organizer to help you remember your medication.

What side effects can this medication cause?

If you experience any unusual or severe side effects while taking Maxzide, you should contact your healthcare provider promptly. Common side effects of Maxzide may include:

  • Increased Urination: Hydrochlorothiazide is a diuretic, which means it can lead to increased urination. This is a common and expected side effect of the medication.
  • Dizziness or Lightheadedness: You may feel dizzy or lightheaded, especially when standing up quickly. This can occur as a result of low blood pressure, which Maxzide is prescribed to treat.
  • Headache: Headaches are a common side effect of Maxzide.
  • Upset Stomach: Some people may experience stomach discomfort, including nausea or diarrhea.
  • Electrolyte Imbalance: Maxzide can affect the balance of electrolytes in your body, including potassium. This can sometimes lead to low potassium levels (hypokalemia). Signs of low potassium can include muscle weakness, cramps, and irregular heartbeats.
  • Skin Reactions: Skin rash or itching can occur as a side effect.
  • Sensitivity to Sunlight: Some individuals may become more sensitive to sunlight (photosensitivity) while taking Maxzide. This can increase the risk of sunburn.
  • Elevated Blood Sugar: Hydrochlorothiazide may increase blood sugar levels in some people, which can be a concern for individuals with diabetes.

Less common but potentially serious side effects of Maxzide may include:

  • Severe Allergic Reactions: Allergic reactions to medications, although rare, can occur. Seek immediate medical attention if you experience symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing.
  • Signs of High Potassium Levels (Hyperkalemia): While Maxzide contains triamterene to conserve potassium, high potassium levels can still occur, especially if you consume a high-potassium diet or take potassium supplements. Symptoms of hyperkalemia can include muscle weakness, irregular heartbeat, and a feeling of numbness or tingling.
  • Kidney Dysfunction: Maxzide can affect kidney function, and in rare cases, it may lead to acute kidney injury. Symptoms may include changes in urination or swelling in the ankles or feet.
  • Blood Disorders: Maxzide can lead to blood disorders such as low levels of platelets or white blood cells, although this is relatively rare.

It’s important to remember that not everyone will experience these side effects, and many people tolerate Maxzide well. Your healthcare provider will monitor your progress and may adjust your treatment or dosage if needed based on your individual response to the medication.

If you have concerns about potential side effects or experience any unusual or severe symptoms while taking Maxzide, consult your healthcare provider for guidance and appropriate evaluation. Do not stop taking the medication without discussing it with your doctor, as abruptly discontinuing it can have adverse effects on your health.

What should I know about storage and disposal of this medication?

Storage and Disposal of Maxzide:


  • Store Maxzide at room temperature, away from moisture, heat, and light.
  • Keep the medication in its original container with the cap tightly closed.
  • Make sure to store it out of the reach of children and pets.


  • When you no longer need Maxzide or when it has expired, do not dispose of it by flushing it down the toilet or pouring it down the drain unless specifically instructed to do so by your healthcare provider or pharmacist.
  • Follow any local or national regulations for medication disposal. Many areas have take-back programs or special disposal facilities for unused medications.
  • If you are unsure how to properly dispose of Maxzide, consult your pharmacist or healthcare provider for guidance.

In case of emergency/overdose

In case of a potential Maxzide overdose or emergency, you should:

  • Contact your local poison control center at 1-800-222-1222 (or the emergency services number in your country) immediately.
  • Go to the nearest emergency room or call 911.
  • If possible, have the medication container or label with you to provide information about the medication.

What other information should I know

  • Keep all appointments with your healthcare provider for regular check-ups and monitoring of your condition while taking Maxzide.
  • Inform all healthcare professionals involved in your care (including dentists and surgeons) about your Maxzide medication, as it may interact with other medications or anesthesia.
  • Do not share Maxzide with others, as it is prescribed based on your specific medical condition and needs.
  • Attend any recommended blood tests or monitoring of electrolyte levels as advised by your doctor.
  • Carry identification or wear a medical alert bracelet to let healthcare providers know that you are taking Maxzide in case of an emergency.

It’s essential to take Maxzide exactly as prescribed by your healthcare provider and to follow their instructions for its use, as well as any dietary and lifestyle recommendations. If you have any questions or concerns about your medication or its storage, disposal, or usage, consult with your healthcare provider or pharmacist for clarification and guidance. Your healthcare team is there to help ensure your safety and well-being while taking Maxzide.

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