WARNING

Mavacamten is a medication used to treat a condition called obstructive hypertrophic cardiomyopathy (HCM), a rare heart disease. While it can be effective in managing the condition, there are potential risks and side effects associated with its use. It’s important to note that you should consult a healthcare professional or refer to the most up-to-date medical literature for the latest information. Some potential risks of taking Mavacamten include:

• Cardiovascular Side Effects: Mavacamten may lead to cardiovascular side effects, such as low blood pressure (hypotension), abnormal heart rhythms (arrhythmias), and a risk of worsening heart failure. Close monitoring by a healthcare provider is essential to manage these risks.
• Muscle Symptoms: Some individuals may experience muscle-related symptoms, including muscle pain, weakness, and elevated levels of certain enzymes in the blood. These symptoms should be reported to a healthcare provider.
• Interactions with Other Medications: Mavacamten may interact with other medications, potentially affecting their effectiveness or causing adverse reactions. It’s crucial to inform your healthcare provider about all the medications, supplements, and over-the-counter drugs you are taking.
• Liver Enzyme Elevations: Mavacamten may cause elevated liver enzymes, which could indicate liver problems. Regular liver function monitoring is necessary while taking this medication.
• Allergic Reactions: Some individuals may experience allergic reactions to Mavacamten, which can include symptoms like rash, itching, swelling, severe dizziness, and difficulty breathing. Seek immediate medical attention if you experience these symptoms.
• Pregnancy and Breastfeeding: The safety of Mavacamten during pregnancy and breastfeeding is not well-established. Women who are pregnant or planning to become pregnant should discuss the potential risks and benefits with their healthcare provider.
• Kidney Function: Mavacamten may affect kidney function in some individuals. Regular monitoring of kidney function may be necessary during treatment.
• Dizziness and Fainting: Mavacamten can cause dizziness, and in some cases, fainting. Patients should be cautious when performing activities that require alertness, such as driving, especially when starting the medication.

It’s crucial for individuals prescribed Mavacamten to have open and regular communication with their healthcare provider. Your doctor will assess your individual health status and closely monitor you for any potential side effects or complications while on the medication. The benefits and risks of Mavacamten should be carefully weighed in consultation with a medical professional, and any concerns or side effects should be promptly reported.

Why is this medication prescribed?

Mavacamten is a medication prescribed for the treatment of a certain type of heart condition called obstructive hypertrophic cardiomyopathy (HCM). HCM is a genetic condition in which the heart muscle becomes abnormally thick, making it harder for the heart to pump blood effectively. This can lead to symptoms such as chest pain, shortness of breath, fatigue, and an increased risk of abnormal heart rhythms.

Mavacamten works by reducing the thickening of the heart muscle and improving the heart’s ability to pump blood. It is considered a disease-modifying therapy for HCM and can help alleviate symptoms and improve the overall function of the heart.

How should this medicine be used?

Here are some general guidelines for how Mavacamten is typically used, but you should always follow your doctor’s specific instructions:

• Dosage: The dosage of Mavacamten can vary depending on your individual medical condition and needs. Your doctor will determine the appropriate dosage for you.
• Administration: Mavacamten is usually taken by mouth in the form of tablets or capsules. It is typically taken once a day, with or without food.
• Follow your doctor’s instructions: It’s essential to follow your healthcare provider’s instructions carefully when taking Mavacamten. Do not change the dosage or stop taking the medication without consulting your doctor, even if you start to feel better.
• Regular monitoring: Your doctor may perform regular tests, such as echocardiograms and blood tests, to monitor your response to Mavacamten and ensure it is effectively managing your condition.
• Adherence: It’s important to take Mavacamten consistently as prescribed to get the maximum benefit from the medication.
• Potential side effects: Like all medications, Mavacamten may have side effects. Common side effects may include headache, dizziness, nausea, and diarrhea. If you experience any unusual or severe side effects, contact your healthcare provider.
• Interactions: Inform your doctor about all other medications, supplements, or herbal products you are taking, as Mavacamten may interact with certain drugs.

Remember that the information provided here is for general guidance, and individual recommendations may vary based on your specific medical condition and needs. Always consult with your healthcare provider for personalized advice regarding the use of Mavacamten or any other medication.

Other uses for this medicine

Mavacamten is primarily prescribed for the treatment of obstructive hypertrophic cardiomyopathy (HCM), as it specifically targets the underlying mechanisms of this condition. There are no other widely recognized medical uses for Mavacamten. It is essential to use this medication only as prescribed by your healthcare provider for the approved indication.

What special precautions should I follow?

Special precautions should be taken when using Mavacamten, and it’s crucial to discuss your medical history and any other medications or supplements you are taking with your doctor to ensure its safe and effective use. Here are some special precautions to consider:

• Allergies: Inform your healthcare provider if you are allergic to Mavacamten or any other medications.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Mavacamten with your doctor. The safety of Mavacamten during pregnancy and breastfeeding has not been extensively studied.
• Liver or kidney problems: Inform your doctor if you have a history of liver or kidney problems, as they may need to adjust the dosage of Mavacamten accordingly.
• Medication interactions: Mavacamten may interact with other medications you are taking. Inform your doctor about all prescription and over-the-counter medications, supplements, and herbal products you are using to prevent potential drug interactions.
• Cardiovascular conditions: If you have other cardiovascular conditions or are taking medications for heart-related issues, discuss them with your doctor, as Mavacamten is used to treat a specific heart condition (HCM).
• Driving and operating machinery: Mavacamten may cause dizziness as a side effect. If you experience dizziness, use caution when driving or operating heavy machinery.
• Monitoring: Your doctor may monitor your heart function and overall health regularly while you are taking Mavacamten. Be sure to attend all recommended follow-up appointments and tests.
• Missed doses: If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Storage: Store Mavacamten as directed on the medication label, typically at room temperature away from excessive heat and moisture.

Always consult with your healthcare provider for specific guidance on how to take Mavacamten and any additional precautions or considerations based on your individual health and medical history. They can provide you with the most up-to-date information and tailored advice regarding your treatment.

What special dietary instructions should I follow?

Special Dietary Instructions:

• Food Timing: Mavacamten can be taken with or without food. You can choose to take it with a meal or on an empty stomach, depending on your preference and any guidance provided by your doctor.
• Grapefruit and Grapefruit Juice: Grapefruit and grapefruit juice can interact with certain medications, including Mavacamten. It’s generally advisable to avoid consuming grapefruit or its juice while taking this medication, as it may increase the risk of side effects or alter its effectiveness.

What should I do if I forget a dose?

Regarding what to do if you forget a dose of Mavacamten:

• If you forget to take a dose of Mavacamten, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.
• If you have trouble remembering to take your medication, consider setting alarms or using a pill organizer to help you stay on track.

What side effects can this medication cause?

Mavacamten, like any medication, can cause side effects. It’s important to note that not everyone who takes Mavacamten will experience these side effects, and some individuals may experience them to a greater degree than others. Common side effects and less common, but more serious, side effects associated with Mavacamten include:

Common Side Effects:

• Headache: Mild to moderate headaches are a relatively common side effect of Mavacamten.
• Dizziness: Some individuals may experience dizziness or lightheadedness while taking the medication.
• Nausea: Nausea and, less commonly, vomiting can occur as side effects of Mavacamten.
• Diarrhea: Diarrhea is another possible gastrointestinal side effect of this medication.

Less Common but Serious Side Effects:

• Low Blood Pressure: Mavacamten can lead to a drop in blood pressure, which may result in symptoms such as fainting, lightheadedness, or feeling weak. If you experience these symptoms, contact your healthcare provider promptly.
• Abnormal Heart Rhythms (Arrhythmias): In some cases, Mavacamten can cause or worsen abnormal heart rhythms. If you notice irregular heartbeats, chest pain, or palpitations, seek medical attention right away.
• Liver Problems: While rare, Mavacamten may lead to liver problems. If you experience symptoms such as yellowing of the skin or eyes (jaundice), dark urine, or persistent abdominal pain, inform your doctor immediately.
• Hypertension: Some individuals may experience an increase in blood pressure while taking Mavacamten. Regular monitoring of blood pressure is essential during treatment.
• Allergic Reactions: Allergic reactions to medications can occur, though they are rare. Seek medical attention immediately if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s essential to discuss any side effects or concerns with your healthcare provider. They can help you assess the risks and benefits of Mavacamten and may make adjustments to your treatment plan if necessary. Do not stop taking Mavacamten or change your dosage without consulting your doctor, as abrupt discontinuation can have adverse effects on your heart condition.

Keep in mind that this list is not exhaustive, and individual responses to medication can vary. Your healthcare provider can provide you with the most up-to-date information on Mavacamten’s side effects and how to manage them effectively.

What should I know about storage and disposal of this medication?

Storage and disposal of Mavacamten:

Storage:

• Store Mavacamten as directed on the medication label. Typically, it should be stored at room temperature, away from excessive heat and moisture.
• Keep the medication out of reach of children and pets.
• Do not use Mavacamten if it has passed its expiration date. If you have unused or expired medication, follow proper disposal guidelines (see below).

Disposal:

• Do not dispose of Mavacamten by flushing it down the toilet or pouring it down the drain unless specifically instructed to do so by your healthcare provider or the medication’s labeling.
• Check with your local pharmacy or healthcare facility for information on safe medication disposal programs in your area. Many places have designated drop-off locations for expired or unused medications.
• If no disposal program is available, you can mix the medication with an undesirable substance (like coffee grounds or kitty litter) and place it in a sealed plastic bag before disposing of it in your household trash. This helps deter accidental ingestion by humans or animals.

In case of emergency/overdose

If you suspect an overdose or experience severe adverse reactions to Mavacamten, seek immediate medical attention or contact a poison control center at 1-800-222-1222 (if available in your country).

What other information should I know?

• Always take Mavacamten exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your doctor, even if you start to feel better.
• Inform your healthcare provider about all other medications, supplements, or herbal products you are taking, as Mavacamten may interact with certain drugs.
• Attend all follow-up appointments and medical tests recommended by your doctor to monitor your response to Mavacamten and assess any potential side effects.
• It’s essential to maintain a healthy lifestyle and follow your doctor’s advice regarding diet, exercise, and other lifestyle modifications to manage your heart condition effectively.
• If you experience any unusual or severe side effects while taking Mavacamten, contact your healthcare provider promptly.
• Keep an up-to-date list of all your medications, including Mavacamten, and share it with any healthcare provider you consult, including specialists and emergency medical personnel.

Remember that the information provided here is for general guidance. Always follow your healthcare provider’s specific instructions regarding Mavacamten and reach out to them with any questions or concerns you may have about the medication.