Why is this medication prescribed?

Maralixibat is a medication prescribed to treat certain liver disorders, specifically a rare genetic condition called Alagille syndrome and another rare liver disease called progressive familial intrahepatic cholestasis (PFIC). These conditions are characterized by problems with the flow of bile from the liver, leading to the buildup of bile acids in the liver and bloodstream. Maralixibat works by reducing the production and absorption of bile acids in the intestine, which can help alleviate some of the symptoms associated with these conditions and improve liver function.

How should this medicine be used?

Here’s how Maralixibat is typically used:

• Dosage: The dosage of Maralixibat will be determined by your healthcare provider based on your age, weight, and the specific liver condition you have. It is available in oral suspension form.
• Administration: Maralixibat comes as a solution (liquid) to take by mouth. Maralixibat is usually taken by mouth, either with or without food, as directed by your doctor. It is important to follow your doctor’s instructions carefully and not to change the dosage or schedule without their guidance.
• Timing: You should take Maralixibat at the same times each day to maintain a consistent level of the medication in your bloodstream.
• Shake well: Before each use, be sure to shake the bottle of Maralixibat oral suspension to ensure that the medication is evenly mixed.
• Follow-up appointments: Your doctor will likely monitor your progress and may adjust your dosage as needed. Be sure to attend all scheduled follow-up appointments to assess the effectiveness of the medication and to check for any side effects or changes in your liver function.
• Storage: Store Maralixibat according to the instructions provided with the medication. Typically, it should be stored at room temperature, away from light and moisture.

It’s crucial to take Maralixibat exactly as prescribed by your healthcare provider. If you have any questions or concerns about the medication, its usage, or any potential side effects, do not hesitate to discuss them with your healthcare team.

Please note that the information provided here is for general knowledge, and you should always follow the specific instructions given by your healthcare provider and refer to the medication’s packaging for any additional guidance or warnings.

Other uses for this medicine

Maralixibat is primarily prescribed for the treatment of Alagille syndrome and progressive familial intrahepatic cholestasis (PFIC), which are specific liver disorders characterized by bile flow problems. It is essential to use this medication only as prescribed by your healthcare provider for these conditions, as it is not intended for other uses.

What special precautions should I follow?

Special precautions and considerations to keep in mind when using Maralixibat include:

• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, you should inform your healthcare provider before starting Maralixibat. The effects of Maralixibat during pregnancy and breastfeeding are not well studied, and your doctor will assess the potential risks and benefits before recommending its use.
• Liver Function Monitoring: Your doctor will likely monitor your liver function regularly while you are taking Maralixibat. They may order blood tests to check liver enzymes and bile acid levels to ensure that the medication is working effectively and not causing harm to your liver.
• Adherence to Dosage: It is crucial to take Maralixibat exactly as prescribed by your healthcare provider. Do not skip doses or change the dosage without consulting your doctor. Consistent use is essential for managing your liver disorder effectively.
• Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking. Maralixibat may interact with other medications, potentially affecting their effectiveness or causing adverse effects.
• Side Effects: Be aware of potential side effects associated with Maralixibat. Common side effects may include diarrhea, abdominal pain, vomiting, and increased liver enzyme levels. If you experience severe or persistent side effects, contact your doctor.
• Allergies: If you have known allergies to any components of Maralixibat, inform your healthcare provider, as you should not take the medication if you are allergic to it.
• Children: Maralixibat may be prescribed to children with specific liver disorders. Pediatric dosing and monitoring may differ, so follow your child’s healthcare provider’s recommendations carefully.
• Driving and Operating Machinery: Maralixibat is not known to impair your ability to drive or operate machinery. However, if you experience any side effects that affect your alertness or coordination, exercise caution while performing these activities.
• Storage: Store Maralixibat according to the instructions provided with the medication. Typically, it should be kept at room temperature, away from light and moisture.

Always consult with your healthcare provider for personalized guidance and to address any concerns or questions you may have regarding Maralixibat. They can provide you with the most up-to-date information based on your specific medical condition and needs.

What special dietary instructions should I follow?

Here are some general guidelines for taking medications like Maralixibat:

• Your healthcare provider may provide specific dietary guidance based on your individual needs and condition. However, in general:
• Follow a balanced and healthy diet recommended by your healthcare provider or a registered dietitian.
• Maintain adequate hydration by drinking plenty of water.
• Limit or avoid alcohol consumption as it can affect liver function.

What should I do if I forget a dose?

If you forget to take a dose of Maralixibat, follow these general guidelines:

• If you forget to take a dose of Maralixibat, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule.
• Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Maralixibat, like any medication, can potentially cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. Common side effects of Maralixibat may include:

• Diarrhea: Diarrhea is one of the most common side effects of Maralixibat. It can range from mild to severe. If diarrhea persists or becomes severe, contact your healthcare provider.
• Abdominal Pain: Some people may experience abdominal discomfort or pain while taking Maralixibat. If this symptom is severe or persistent, notify your doctor.
• Vomiting: Vomiting may occur in some individuals as a side effect of Maralixibat. If you experience frequent or severe vomiting, consult your healthcare provider.
• Increased Liver Enzymes: Maralixibat can sometimes lead to an increase in liver enzyme levels in the blood. Your healthcare provider will monitor your liver function with regular blood tests.
• Gastrointestinal Symptoms: Other gastrointestinal symptoms, such as nausea or bloating, can occur in some individuals.
• Decreased Appetite: Some people may experience a decreased appetite while taking Maralixibat.
• Headache: Headaches have been reported as a side effect of Maralixibat.

It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed here. Additionally, the severity and duration of side effects can vary.

If you experience any side effects while taking Maralixibat, especially if they are severe, persistent, or concerning, it’s essential to contact your healthcare provider. They can provide guidance on how to manage these side effects and may adjust your treatment plan if necessary.

Keep in mind that your healthcare provider has prescribed Maralixibat because they have determined that the potential benefits outweigh the risks of side effects. It’s essential to continue taking the medication as directed unless instructed otherwise by your healthcare provider. If you have questions or concerns about the side effects of Maralixibat, discuss them with your healthcare team.

What should I know about storage and disposal of this medication?

Storage:

• Storage: Follow the storage instructions provided with your specific Maralixibat medication. In general, it is typically stored at room temperature, away from direct light and moisture. Keep the medication out of reach of children and pets.
• Do Not Freeze: Do not freeze Maralixibat.
• Do Not Use Expired Medication: Check the expiration date on the medication packaging, and do not use Maralixibat if it has expired. Properly dispose of expired medication.
• Keep the Container Closed: Always keep the bottle or container of Maralixibat tightly closed when not in use.

Disposal:

• Do not dispose of medications in wastewater or household waste unless instructed to do so. Properly dispose of this product when it is no longer needed or has expired.
• Contact your healthcare provider or a local pharmacy for guidance on how to dispose of Maralixibat safely and in an environmentally friendly manner.

In case of emergency/overdose

If you suspect an overdose or experience severe adverse effects after taking Maralixibat, seek medical attention or contact your local poison control center immediately. Symptoms of overdose may include severe diarrhea, abdominal pain, and vomiting. It’s important to have a healthcare professional evaluate your condition and provide appropriate treatment if necessary.

What other information should I know?

• Follow Doctor’s Instructions: Always take Maralixibat as prescribed by your healthcare provider. Do not change the dosage or stop taking it without consulting your doctor.
• Regular Monitoring: Your doctor may schedule regular check-ups and blood tests to monitor your condition and ensure the medication is working effectively.
• Keep a Medication List: Maintain a list of all the medications you are taking, including Maralixibat, and share it with any healthcare provider you see. This list should include prescription medications, over-the-counter drugs, and dietary supplements.
• Inform Healthcare Providers: Before starting any new medications or undergoing surgery, inform your healthcare providers that you are taking Maralixibat.
• Report Side Effects: If you experience any unusual or severe side effects while taking Maralixibat, report them to your healthcare provider promptly.
• Patient Education: Ensure you understand how to take Maralixibat correctly, including dosing instructions and any dietary recommendations provided by your doctor.
• Storage Information: Keep the medication stored safely and out of the reach of children and pets, as mentioned earlier.

Always rely on your healthcare provider for personalized information and guidance related to your specific medical condition and medication regimen.