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Why is this medication prescribed?

Maprotiline is a medication that belongs to the class of drugs known as tricyclic antidepressants (TCAs). It is prescribed for the treatment of depression, particularly in cases where other antidepressant medications have not been effective or when a doctor believes it is the most suitable option based on a patient’s specific needs.

How should this medicine be used?

Here are some key points about the use of Maprotiline:

  • Treatment of Depression: Maprotiline is primarily prescribed to alleviate the symptoms of depression, such as persistent sadness, loss of interest in daily activities, changes in appetite or sleep patterns, and feelings of hopelessness.
  • Dosage: The dosage of Maprotiline can vary from person to person, and it is essential to follow your doctor’s prescription carefully. The medication typically comes in tablet or capsule form, and the dosage may be adjusted over time to achieve the best therapeutic effect with minimal side effects.
  • Frequency: Typically, Maprotiline is taken once daily, usually at bedtime, to minimize daytime drowsiness, which can be a common side effect of TCAs. Follow your doctor’s instructions regarding the specific timing and frequency of your doses.
  • Duration: The duration of Maprotiline treatment can vary depending on the individual’s response to the medication and the severity of their depression. It’s essential to continue taking the medication as prescribed, even if you start to feel better. Stopping it abruptly can lead to withdrawal symptoms and a return of depression.
  • Side Effects: Like all medications, Maprotiline may cause side effects. Common side effects can include dry mouth, dizziness, drowsiness, constipation, blurred vision, and weight gain. Serious side effects can also occur, so it’s essential to report any unusual or severe symptoms to your healthcare provider promptly.
  • Precautions: Maprotiline should be used with caution in individuals with certain medical conditions, such as heart problems, glaucoma, urinary retention, and a history of seizures. Inform your doctor about your complete medical history and any other medications or supplements you are taking to avoid potential interactions.
  • Monitoring: While taking Maprotiline, your doctor may periodically monitor your progress and adjust the dosage as needed. This helps ensure that you are receiving the right treatment for your depression.
  • Discontinuation: If you and your doctor decide to stop Maprotiline, it is generally recommended to taper the dose gradually under medical supervision to reduce the risk of withdrawal symptoms.

It’s crucial to follow your doctor’s advice carefully when using Maprotiline or any prescription medication. If you have questions or concerns about the medication or its usage, don’t hesitate to discuss them with your healthcare provider to ensure safe and effective treatment. Additionally, never adjust your dosage or stop taking Maprotiline without consulting your healthcare provider, as abruptly discontinuing the medication can have adverse effects.

Other uses for this medicine

While maprotiline is primarily prescribed for depression, it has been used off-label for other conditions, such as:

  • Anxiety disorders: In some cases, healthcare providers may prescribe maprotiline for certain anxiety disorders.
  • Neuropathic pain: Maprotiline may be used to manage neuropathic pain, such as diabetic neuropathy.

It’s important to note that using maprotiline for these off-label purposes should only be done under the supervision and guidance of a qualified healthcare professional.

What special precautions should I follow?

Regarding special precautions for using Maprotiline, here are some important considerations:

  • Follow your healthcare provider’s instructions: Always take maprotiline exactly as prescribed by your doctor. Do not change the dosage or stop taking it without consulting your healthcare provider.
  • Regular monitoring: Your doctor may want to monitor your progress closely while you’re taking maprotiline. Attend all scheduled appointments and communicate any changes in your mood or side effects promptly.
  • Suicidal thoughts: Antidepressant medications, including maprotiline, can increase the risk of suicidal thoughts, especially in young adults and adolescents. Be vigilant for changes in your mood or any new or worsening symptoms and inform your doctor immediately if you experience suicidal thoughts.
  • Avoid alcohol: Alcohol can interact with maprotiline and increase its sedative effects. Avoid alcohol while taking this medication.
  • Driving and operating machinery: Maprotiline may cause drowsiness and impair your ability to drive or operate heavy machinery. Use caution when engaging in activities that require mental alertness.
  • Inform healthcare providers: Before undergoing any surgical or dental procedures, inform the healthcare professionals involved that you are taking maprotiline, as it can interact with certain anesthetics and other medications.

Always follow your healthcare provider’s instructions regarding the use of Maprotiline, including dosages and any precautions specific to your individual circumstances. If you experience any concerning side effects or have questions about your treatment, do not hesitate to contact your healthcare provider for guidance and support.

What special dietary instructions should I follow?

Here are some general dietary guidelines:

  • Dietary restrictions: There are no specific dietary restrictions associated with maprotiline. However, it’s generally a good idea to maintain a balanced diet while taking any medication. If you have specific dietary concerns or restrictions, discuss them with your healthcare provider or a registered dietitian.
  • Grapefruit and grapefruit juice: Some medications, including maprotiline, can interact with grapefruit and its juice, potentially leading to increased levels of the medication in your bloodstream. It’s generally advisable to avoid grapefruit and its products while taking maprotiline.

What should I do if I forget a dose?

If you forget to take a dose of maprotiline, take it as soon as you remember, unless it’s close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one, as this can increase the risk of side effects.

What side effects can this medication cause?

Maprotiline is a tricyclic antidepressant (TCA) medication used to treat depression. Like many medications, it can have side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience them to a greater degree than others. If you have been prescribed Maprotiline and are concerned about its side effects, it’s essential to discuss them with your healthcare provider. Here are some potential side effects of Maprotiline:

Common side effects:

  • Dry mouth
  • Constipation
  • Drowsiness or sedation
  • Dizziness
  • Blurred vision
  • Increased heart rate (tachycardia)
  • Weight gain

Less common side effects:

  • Tremors
  • Difficulty urinating
  • Sweating
  • Headache
  • Nausea and vomiting
  • Nervousness or anxiety
  • Insomnia or sleep disturbances
  • Changes in sexual desire or function
  • Rash or itching

Rare but serious side effects:

  • Changes in heart rhythm (arrhythmias)
  • Increased blood pressure
  • Seizures
  • Hallucinations or confusion
  • Allergic reactions, which may include rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s important to be aware of the potential side effects of Maprotiline and to contact your healthcare provider if you experience any severe or concerning symptoms. TCAs like Maprotiline may have drug interactions with other medications, so it’s crucial to inform your doctor about all the medications, supplements, and herbal products you are taking. Additionally, TCAs can have a risk of overdose, so it’s essential to take them only as prescribed by your healthcare provider and to seek medical attention immediately in case of an overdose or any unusual symptoms.

This list of side effects is not exhaustive, and individual experiences may vary. Always consult with your healthcare provider for the most accurate and up-to-date information on potential side effects and the use of Maprotiline.

What should I know about storage and disposal of this medication?


  • Follow Label Instructions: Store Maprotiline according to the instructions on the medication label or as directed by your healthcare provider or pharmacist.
  • Room Temperature: Generally, Maprotiline should be stored at room temperature, away from excessive heat, light, and moisture.
  • Keep Out of Reach: Store the medication in a location that is out of reach of children and pets to prevent accidental ingestion.
  • Child-Resistant Packaging: Ensure that the medication container has child-resistant packaging, and always secure the lid or cap tightly after each use.


  • Do Not Flush: Do not flush Maprotiline tablets or capsules down the toilet, as this can contaminate water sources.
  • Medication Take-Back Programs: If available in your area, consider using a medication take-back program or collection site to safely dispose of unused or expired Maprotiline. These programs can help ensure proper disposal and prevent environmental contamination.
  • Mix with Unpalatable Substance: To safely dispose of Maprotiline at home, you can mix the unused medication with an undesirable substance, such as used coffee grounds or cat litter, in a sealed plastic bag. This can help deter accidental ingestion by others. Then, throw the bag in the household trash.

In case of emergency/overdose

In the case of a suspected overdose or any medical emergency related to Maprotiline, it’s crucial to take immediate action:

  • Seek Medical Assistance: Call 911 or your local emergency number immediately if you or someone else has taken more Maprotiline than prescribed or is experiencing severe symptoms.
  • Poison Control Center: Contact your local poison control center or the national Poison Help hotline at 1-800-222-1222 for guidance on overdose management.
  • Provide Information: Be ready to provide information about the medication, including the dose, when it was taken, and any symptoms experienced.

What other information should I know

It’s essential to take Maprotiline exactly as prescribed by your healthcare provider. Follow their instructions regarding dosage, timing, and duration of treatment. Do not stop taking the medication abruptly or make dosage adjustments without consulting your healthcare provider, as this can lead to withdrawal symptoms or a recurrence of depression.

Additionally, inform your healthcare provider of any other medications, supplements, or herbal products you are taking to avoid potential drug interactions. Attend regular follow-up appointments to monitor your progress and discuss any concerns or side effects.

Always consult with your healthcare provider or pharmacist if you have questions or need clarification about your medication, its storage, disposal, or emergency procedures.

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