PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Macrodantin (Generic Nitrofurantoin)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Macrodantin is a brand name for nitrofurantoin, which is an antibiotic used to treat urinary tract infections (UTIs). Nitrofurantoin is effective against certain bacteria that commonly cause UTIs, such as Escherichia coli (E. coli). It works by interfering with the growth of bacteria, preventing them from multiplying and causing infection.

How should this medicine be used?

Here are some general guidelines on how Macrodantin (nitrofurantoin) is commonly prescribed and used:

  • Indications: Macrodantin is primarily prescribed for the treatment of uncomplicated urinary tract infections caused by susceptible bacteria.
  • Dosage:The dosage of Macrodantin can vary based on factors like the severity of the infection, the patient’s age, and kidney function. It is typically taken with food to enhance absorption.
  • Frequency: Macrodantin is usually taken two or four times a day, as prescribed by a healthcare professional.
  • Duration: The full course of antibiotic treatment should be completed even if symptoms improve before the medication is finished. This helps prevent the development of antibiotic-resistant bacteria.
  • Administration: Macrodantin is taken orally, usually in the form of capsules. The capsules should be swallowed whole with a full glass of water. They should not be crushed or chewed.
  • Monitoring: Patients may be monitored for any side effects, and periodic blood tests may be done to check for potential complications.
  • Follow Doctor’s Instructions: It’s crucial to follow the prescribing doctor’s instructions carefully. If there are any concerns or questions about the medication, it’s essential to consult the healthcare provider.
  • Allergies and Precautions: Inform the healthcare provider about any allergies to nitrofurantoin or any other medications. Mention any other medications or supplements being taken to avoid potential interactions.
  • Side Effects: Common side effects may include nausea, vomiting, and diarrhea. If these symptoms are severe or persistent, medical attention should be sought. Rare but serious side effects may include lung problems, so it’s important to report any difficulty breathing, persistent cough, or chest pain.

Other uses for this medicine

Macrodantin (nitrofurantoin) is primarily used for the treatment of urinary tract infections (UTIs). However, there may be some instances where healthcare providers prescribe it for other purposes, often off-label. Off-label use refers to the use of a medication for a condition or purpose other than what it is approved for by regulatory authorities. If your doctor has prescribed Macrodantin for a specific condition, it’s important to follow their guidance and instructions.

What special precautions should I follow?

Special precautions should be taken when using Macrodantin, and it’s crucial to inform your healthcare provider about your medical history, existing conditions, and any other medications or supplements you are taking. Here are some general precautions associated with Macrodantin:

  • Allergies: Inform your healthcare provider if you are allergic to nitrofurantoin or any other medications.
  • Kidney Function: Macrodantin is primarily eliminated through the kidneys. If you have impaired kidney function, your doctor may need to adjust the dosage accordingly.
  • G6PD Deficiency: Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency may be at risk for hemolysis (breakdown of red blood cells) when taking nitrofurantoin. This should be discussed with your healthcare provider.
  • Pregnancy and Breastfeeding: Nitrofurantoin is generally considered safe to use during pregnancy, especially in the later stages. However, the doctor will assess the potential risks and benefits. It can be excreted into breast milk, and caution is advised if used during breastfeeding.
  • Respiratory Symptoms: Nitrofurantoin may cause lung problems in rare cases. Inform your healthcare provider if you experience difficulty breathing, persistent cough, or chest pain.
  • Peripheral Neuropathy: There have been rare reports of peripheral neuropathy (nerve damage) associated with nitrofurantoin use. Inform your doctor if you experience any unusual sensations or numbness in the hands or feet. Patients with liver problems may need special monitoring and dosage adjustments.
  • Interactions with Other Medications: Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, that you are taking, as nitrofurantoin may interact with certain medications.

Always follow your healthcare provider’s instructions regarding the use of Macrodantin, and don’t hesitate to ask questions if you have any concerns about its use or potential side effects. If you experience severe side effects or allergic reactions, seek medical attention promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Macrodantin. However, taking it with food or milk can help reduce the risk of stomach upset. Ensure a balanced diet and stay hydrated.

What should I do if I forget a dose?

If you miss a dose of Macrodantin, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one. If you have any concerns or questions about missed doses, consult with your healthcare provider.

What side effects can this medication cause?

Macrodantin, also known as nitrofurantoin, is an antibiotic commonly used to treat urinary tract infections. Like any medication, it can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed. If you have concerns about Macrodantin or are experiencing any unusual symptoms, it’s crucial to contact your healthcare provider.

Common side effects of Macrodantin may include:

  • Gastrointestinal Effects:
    • Nausea
    • Vomiting
    • Loss of appetite
    • Diarrhea
  • Respiratory Effects:
    • Cough
    • Shortness of breath
  • Hematologic Effects:
    • A decrease in certain types of blood cells (hemolytic anemia)
  • Central Nervous System Effects:
    • Headache
    • Dizziness
  • Dermatologic Effects:
    • Rash
    • Itching
  • Other Effects:
    • Darkening of urine (this is normal and harmless)
    • Peripheral neuropathy (numbness or tingling in the hands or feet)

It’s important to seek medical attention if you experience severe or persistent side effects. Additionally, some people may be allergic to Macrodantin and could experience more serious reactions, such as:

  • Severe skin reactions (e.g., Stevens-Johnson syndrome)
  • Liver problems
  • Pulmonary reactions (lung problems)

If you notice symptoms like difficulty breathing, chest pain, persistent cough, or severe skin reactions, seek medical attention promptly.

It’s crucial to take the medication exactly as prescribed by your healthcare provider and to complete the entire course of treatment, even if symptoms improve before the medication is finished. If you have any concerns or questions about the side effects of Macrodantin, consult with your healthcare provider. They can provide guidance based on your specific health history and circumstances.

What should I know about storage and disposal of this medication?


  • Store Macrodantin at room temperature away from moisture, heat, and light.
  • Keep the medication in its original container, and make sure the container is tightly closed.
  • Do not store Macrodantin in the bathroom.


  • Follow your local guidelines for medication disposal. Do not flush medications down the toilet unless instructed to do so.
  • Dispose of expired or unused medication properly. Many pharmacies have programs for safe disposal.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms, seek emergency medical attention. Symptoms of an overdose may include nausea, vomiting, loss of appetite, drowsiness, yellowing of the skin or eyes (jaundice), or dark urine.

What other information should I know?

  • Regular Follow-ups: Attend scheduled follow-up appointments with your healthcare provider to monitor your response to the medication and assess any potential side effects.
  • Inform Healthcare Providers: Make sure to inform any healthcare provider (including dentists and emergency room doctors) about all the medications you are taking, including Macrodantin.
  • Lab Tests: Your healthcare provider may order periodic lab tests to monitor your kidney function and the effectiveness of the medication.
  • Avoid Antacids: If you are taking antacids, they should be taken at least two hours before or after taking Macrodantin, as they may interfere with the absorption of the medication.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Macrodantin during pregnancy and breastfeeding should be discussed with your healthcare provider.
  • Driving and Operating Machinery: Macrodantin may cause dizziness or drowsiness. Be cautious while driving or operating machinery until you know how the medication affects you.
  • Resistant Bacteria: Using antibiotics like Macrodantin inappropriately or not completing the full course can contribute to the development of antibiotic-resistant bacteria. Follow your healthcare provider’s instructions precisely.
  • Side Effects: Be aware of potential side effects and report any unusual or severe symptoms to your healthcare provider promptly.

Always consult with your healthcare provider or pharmacist for specific and personalized guidance based on your health condition and medical history. The information provided here is general and may not cover all individual cases.

Copyright © 2023