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Lunesta (Generic Eszopiclone)

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WARNING

Eszopiclone may cause serious or possibly life-threatening sleep behaviors. Some people who took eszopiclone got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, sleep-walked, or were involved in other activities while not fully awake. After they woke up, these people were unable to remember what they had done. Tell your doctor if you have ever had an unusual sleep behavior while taking eszopiclone. Be sure that your family or caregiver are aware that these symptoms are serious and to call your doctor if they occur. Stop taking eszopiclone and call your doctor right away if you find out that you have been driving or doing anything else unusual while you were sleeping.

Why is this medication prescribed?

Eszopiclone is used to treat insomnia (difficulty falling asleep or staying asleep). Eszopiclone is in a class of medications called hypnotics. It works by slowing activity in the brain to allow sleep.

How should this medicine be used?

Eszopiclone comes as a tablet to take by mouth. It is usually taken once a day at bedtime or after unsuccessfully trying to fall asleep. Do not take eszopiclone with or shortly after a heavy, high-fat meal. Eszopiclone may not work well if it is taken with high fat foods. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take eszopiclone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You will probably become very sleepy soon after you take eszopiclone and will remain sleepy for some time after you take the medication. You should only take eszopiclone immediately before you go to bed or after you have gone to bed and have been unable to fall asleep. Only take eszopiclone if you will be able to stay in bed for at least 7 to 8 hours after taking the medication. If you do not go to bed right after you take eszopiclone or if you get up too soon after taking eszopiclone, you may experience dizziness, lightheadedness, hallucinations (seeing things or hearing voices that do not exist), and problems with coordination and memory.

Your doctor may change your dose of eszopiclone during your treatment. Your doctor may increase your dose to help you sleep better or decrease your dose if you are too drowsy during the daytime.

You should be sleeping well within 7 to 10 days after you start taking eszopiclone. Call your doctor if your sleep problems do not improve during this time, if they get worse at any time during your treatment, or if you notice any changes in your thoughts or behavior.

Do not stop taking eszopiclone without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking eszopiclone you may experience withdrawal symptoms such as anxiety, unusual dreams, stomach and muscle cramps,nausea, vomiting, sweating, shakiness, and rarely, seizures.

After you stop taking eszopiclone, you may have more difficulty falling asleep and staying asleep than you did before you took the medication. These sleep problems are normal and usually get better without treatment after one or two nights.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with eszopiclone and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer’s website to obtain the Medication Guide.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking eszopiclone,

  • Tell your doctor and pharmacist if you are allergic to eszopiclone, any other medications, or any of the ingredients in eszopiclone tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; certain antifungals such as itraconazole (Onmel, Sporanox) and ketoconazole (Nizoral); antihistamines; clarithromycin (Biaxin); certain HIV protease inhibitors such as nelfinavir (Viracept) and ritonavir (Norvir); medications for anxiety, mental illness, or seizures; nefazodone; olanzapine (Zyprexa); rifampin (Rifadin, Rimactane); sedatives; other sleeping pills; tranquilizers; and troleandomycin (TAO) (not available in the US). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • Tell your doctor if you drink or have ever drunk large amounts of alcohol and if you use or have ever used street drugs or have overused prescription medications. Also tell your doctor if you have ever thought about killing yourself or tried to do so and if you have or have ever had depression, mental illness, lung disease or breathing problems, or liver disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking eszopiclone, call your doctor.
  • Talk to your doctor about the risks and benefits of taking eszopiclone if you are 65 years of age or older. Older adults should not usually take eszopiclone because it is not as safe or effective as other medications that can be used to treat the same condition.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking eszopiclone.
  • You should know that eszopiclone may make you drowsy during the daytime, may decrease your mental alertness, and may increase the risk that you could fall. Take extra care to be sure you do not fall, especially if you get out of bed in the middle of the night. Do not drive a car or operate machinery until you know how this medication affects you.
  • Do not drink alcohol while you are taking eszopiclone. Alcohol can make the side effects from eszopiclone worse.
  • You should know that your mental health may change in unexpected ways while you are taking this medication. These changes may be caused by eszopiclone or they may be caused by physical or mental illnesses that you already have or that you develop during your treatment. Tell your doctor right away if you experience any of the following symptoms: aggressiveness, strange or unusually outgoing behavior, hallucinations (seeing things or hearing voices that do not exist), feeling as if you are outside of your body, memory problems, new or worsening depression, thinking about killing yourself, confusion, and any other changes in your usual thoughts or behavior. Be sure that your family knows which symptoms may be serious so that they can call the doctor if you are unable to seek treatment on your own.

What special dietary instructions should I follow?

Talk to your doctor about drinking grapefruit juice while taking this medication.

What should I do if I forget a dose?

Eszopiclone should only be taken at bedtime. If you did not take eszopiclone before you went to bed and you are unable to fall asleep, you may take eszopiclone if you will be able to stay in bed for at least 7 to 8 hours afterward.

What side effects can this medication cause?

Eszopiclone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • Headache
  • Pain
  • Daytime drowsiness
  • Lightheadedness
  • Dizziness
  • Loss of coordination
  • Nausea
  • Vomiting
  • Heartburn
  • Unpleasant taste
  • Dry mouth
  • Unusual dreams
  • Decreased sexual desire
  • Painful menstrual periods
  • Breast enlargement in males

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNINGS or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:

  • Hives
  • Rash
  • Itching
  • Swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
  • Difficulty breathing or swallowing
  • Feeling that the throat is closing
  • Hoarseness

Eszopiclone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • Drowsiness
  • Coma (loss of consciousness for a period of time)

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. Eszopiclone is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Lunesta®
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