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Krintafel (Generic Tafenoquine)

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Why is this medication prescribed?

Tafenoquine is primarily prescribed for the prevention and treatment of malaria, specifically malaria caused by the Plasmodium vivax parasite. Plasmodium vivax malaria is a common type of malaria that can cause recurring episodes of fever and illness if left untreated.

Tafenoquine is used for the following purposes:

  • Malaria Prophylaxis: Tafenoquine is prescribed to individuals who are at risk of contracting Plasmodium vivax malaria in areas where the parasite is prevalent. It is taken as a preventive measure to reduce the risk of developing the infection. It is important to start the medication before entering the malaria-endemic area and continue it for the recommended duration after leaving the area to ensure protection.
  • Malaria Treatment: Tafenoquine is also used for the treatment of acute Plasmodium vivax malaria. It is administered to eliminate the parasite from the body and prevent relapses. Tafenoquine has the advantage of being able to target dormant liver-stage parasites, which can cause relapses weeks or months after the initial infection.

How should this medicine be used?

Tafenoquine should be used as directed by your healthcare professional. It is important to follow the prescribed dosage and administration instructions. Here are some general guidelines for the use of Tafenoquine:

  • Take Tafenoquine with food: Tafenoquine should be taken with a meal to improve its absorption and reduce the risk of stomach upset. This means you should take it during or shortly after a meal.
  • Single-dose administration: Tafenoquine is typically taken as a single dose. The exact dosage and frequency will be determined by your healthcare provider based on factors such as your age, weight, and the specific condition being treated.
  • Complete the full course of treatment: If you are taking Tafenoquine for the treatment of malaria, it is important to complete the full course of treatment as prescribed by your healthcare professional. This helps ensure that the infection is fully cleared and reduces the risk of relapse.
  • Do not exceed the recommended dosage: Take Tafenoquine exactly as prescribed. Do not take more or less of the medication, and do not take it more frequently than recommended. Taking too much Tafenoquine can increase the risk of side effects without providing additional benefit.
  • Follow additional instructions: Your healthcare provider may provide you with additional instructions or precautions based on your individual circumstances. It is important to carefully follow all the guidance provided and ask any questions you may have.

Remember to inform your healthcare provider about any other medications you are taking, as Tafenoquine may interact with certain drugs. They will be able to provide specific guidance on how to use Tafenoquine safely and effectively in your particular situation.

Other uses for this medicine

Tafenoquine is primarily used for the prevention and treatment of malaria caused by the Plasmodium vivax parasite. However, it’s important to note that Tafenoquine has not been approved or indicated for any other uses beyond malaria prevention and treatment. Its effectiveness and safety have been specifically evaluated for these purposes.

What special precautions should I follow?

When using Tafenoquine, it’s essential to take certain precautions. Here are some important considerations:

  • G6PD Deficiency: Tafenoquine can cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD deficiency is an inherited condition that affects red blood cells. Before initiating Tafenoquine treatment, your healthcare provider will conduct a G6PD test to determine if you have this deficiency. Tafenoquine should not be used in individuals with G6PD deficiency due to the risk of severe hemolysis.
  • Pregnancy and Breastfeeding: Tafenoquine is not recommended for use during pregnancy or while breastfeeding. Limited data is available on the safety of Tafenoquine in these situations. If you are pregnant or breastfeeding or planning to become pregnant, discuss the risks and benefits of Tafenoquine with your healthcare provider.
  • Other Medications: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some medications may interact with Tafenoquine and affect its effectiveness or increase the risk of adverse effects. Particularly, certain medications used for the treatment of mental health conditions or heart rhythm disorders may interact with Tafenoquine.
  • Side Effects: Tafenoquine may cause side effects, although not everyone experiences them. Common side effects include headache, dizziness, stomach pain, nausea, vomiting, and itching. If you experience any concerning or persistent side effects, contact your healthcare provider.
  • Compliance: It is crucial to follow the prescribed dosage and treatment duration of Tafenoquine. Skipping doses or stopping treatment prematurely can decrease its effectiveness and increase the risk of malaria infection or relapse.

Always consult with your healthcare provider for personalized advice and information on the specific precautions you should take when using Tafenoquine. They can assess your individual medical history, provide appropriate recommendations, and address any concerns you may have.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with taking Tafenoquine. However, it is generally recommended to take Tafenoquine with food to improve its absorption and reduce the risk of stomach upset. Taking it with a meal or snack that contains some fat may enhance the absorption of the medication. However, it is best to follow the instructions provided by your healthcare professional or the medication label regarding food intake when taking Tafenoquine.

What should I do if I forget a dose?

If you forget to take a dose of Tafenoquine, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

What side effects can this medication cause?

Tafenoquine, like any medication, can cause side effects in some individuals. Not everyone will experience side effects, and the severity and occurrence of side effects can vary. Common side effects of Tafenoquine may include:

  • Gastrointestinal Effects: Nausea, vomiting, abdominal pain, and diarrhea are some of the common gastrointestinal side effects associated with Tafenoquine. Taking the medication with food may help alleviate these symptoms.
  • Headache: Headaches are a reported side effect of Tafenoquine use. If the headaches are severe or persistent, it is advisable to consult your healthcare provider.
  • Dizziness: Tafenoquine can cause dizziness in some individuals. It is important to be cautious while engaging in activities that require alertness, such as driving or operating machinery, especially if you experience dizziness.
  • Itching and Skin Reactions: Itching or skin reactions, such as rashes or hives, have been reported as side effects of Tafenoquine. If you develop any skin-related symptoms, notify your healthcare provider.
  • Mood Changes: Tafenoquine use has been associated with mood changes, including anxiety, depression, and hallucinations. If you experience any significant changes in mood or mental health, it is essential to seek medical attention promptly.
  • Hemolytic Anemia (in G6PD-deficient individuals): Tafenoquine can cause hemolytic anemia, a condition characterized by the destruction of red blood cells, in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD deficiency testing is conducted before starting Tafenoquine to identify those at risk.

These are not all the possible side effects of Tafenoquine. Some individuals may experience rare or more severe side effects. If you notice any unusual or persistent side effects while taking Tafenoquine, it is important to inform your healthcare provider promptly.

What should I know about storage and disposal of this medication?

Storage and disposal of Tafenoquine:

  • Store Tafenoquine tablets at room temperature, away from moisture and heat.
  • Keep the medication in its original container, tightly closed, and out of reach of children and pets.
  • Do not use Tafenoquine tablets that are expired or no longer needed. Properly dispose of them following local regulations or consult with your pharmacist regarding the appropriate disposal method.

In case of emergency/overdose

  • If you believe you have taken too much Tafenoquine or are experiencing severe symptoms, immediately contact emergency services or your local poison control center.
  • Overdosing on Tafenoquine can increase the risk of adverse effects. It is important to seek immediate medical attention if you suspect an overdose.

What other information should I know?

  • Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, before starting Tafenoquine. Some medications may interact with Tafenoquine, affecting its effectiveness or increasing the risk of side effects.
  • Regular monitoring of blood counts may be required during Tafenoquine treatment, particularly in individuals with G6PD deficiency.
  • Follow the complete course of treatment as prescribed, even if you start feeling better. Prematurely stopping the medication can lead to incomplete treatment and may increase the risk of malaria infection or relapse.
  • Tafenoquine does not provide protection against other types of malaria caused by different species of Plasmodium parasites. If you are traveling to an area where other types of malaria are prevalent, additional preventive measures may be necessary.
  • If you experience any new or worsening symptoms while taking Tafenoquine, report them to your healthcare provider.

As always, it is crucial to consult your healthcare provider or pharmacist for personalized advice and complete information regarding the storage, disposal, and other important considerations specific to your Tafenoquine treatment.

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