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Korsuva (Generic Difelikefalin Injection)

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Why is this medication prescribed?

Korsuva (generic name: difelikefalin) is a medication primarily prescribed for the treatment of pruritus, which is a medical term for severe itching. It is specifically used in adult patients who are undergoing hemodialysis, which is a procedure to filter waste and excess fluid from the blood when the kidneys are unable to function properly.

Chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients often experience pruritus as a common symptom. Korsuva works by targeting certain receptors in the body called kappa-opioid receptors, which are involved in the transmission of itch signals. By activating these receptors, Korsuva helps to reduce the intensity of itching in patients undergoing hemodialysis.

However, please note that medical information may have evolved since my last update. It’s always best to consult with a healthcare professional or refer to the most recent medical guidelines for the most accurate and up-to-date information on the uses and prescribing practices of medications.

How should this medicine be used?

The specific instructions for using Korsuva (difelikefalin) should be provided by a healthcare professional, and it’s important to follow their guidance and the instructions on the prescription label. Korsuva is typically administered as an injection.

It is important to note that the dosage and administration of Korsuva may vary depending on individual factors, such as the patient’s medical condition and response to treatment. Therefore, it is crucial to consult a healthcare professional for personalized advice.

If you or someone you know has been prescribed Korsuva, it is recommended to reach out to a healthcare provider, such as a doctor or pharmacist, for detailed instructions on how to use the medication safely and effectively. They can provide the most accurate and up-to-date information based on the latest guidelines and recommendations.

Other uses for this medicine

Korsuva (difelikefalin) is primarily used for the treatment of pruritus (itching) in adult patients undergoing hemodialysis. However, it’s important to note that medical information can change over time, so it’s best to consult with a healthcare professional or refer to the most recent information for any updates on the approved uses of Korsuva.

What special precautions should I follow?

Some general precautions and considerations associated with the use of Korsuva may include:

  • Allergies: Inform your healthcare provider if you have any known allergies or hypersensitivity to difelikefalin or any other medications.
  • Pregnancy and breastfeeding: The safety of Korsuva during pregnancy or breastfeeding has not been well-established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Korsuva with your healthcare provider.
  • Drug interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking. Certain drugs may interact with Korsuva, potentially affecting its effectiveness or increasing the risk of side effects.
  • Side effects: Like any medication, Korsuva may cause side effects. Common side effects may include diarrhea, dizziness, headache, and peripheral edema. However, not everyone experiences these side effects. If you experience any concerning or persistent side effects, contact your healthcare provider.
  • Compliance with instructions: Follow your healthcare provider’s instructions regarding the dosage, administration, and duration of Korsuva treatment. Do not modify the prescribed dose or discontinue the medication without consulting your healthcare provider.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with the use of Korsuva (difelikefalin). However, it’s important to note that medication instructions may vary depending on individual factors and prescribing practices. Therefore, it’s essential to consult with a healthcare professional or refer to the medication’s prescribing information for any specific dietary instructions that may apply to your situation.

What should I do if I forget a dose?

If you forget a dose of Korsuva, it is recommended to take it as soon as you remember. However, if it is close to the time for your next scheduled dose, it’s best to skip the missed dose and continue with your regular dosing schedule. It’s important not to take a double dose to make up for a missed one.

What side effects can this medication cause?

Korsuva (difelikefalin) may cause certain side effects in some individuals. It’s important to note that the severity and occurrence of side effects can vary from person to person. It is always recommended to consult with a healthcare professional or refer to the medication’s prescribing information for the most accurate and up-to-date information.

Common side effects of Korsuva may include:

  • Diarrhea
  • Dizziness
  • Headache
  • Peripheral edema (swelling in the extremities)

These side effects are not experienced by everyone, and some individuals may not experience any side effects at all. If you do experience any side effects, they are usually mild and temporary in nature. However, if you have any concerns or if the side effects persist or worsen, it is important to contact your healthcare provider.

It’s worth noting that this is not an exhaustive list of side effects. Other side effects may occur. If you experience any unusual or severe side effects, it is crucial to seek immediate medical attention.

Additionally, it’s important to report any suspected side effects to your healthcare provider or the relevant regulatory authorities, as this helps in gathering information on the safety of medications and improving patient care.

What should I know about storage and disposal of this medication?


  • Follow the storage instructions provided by your healthcare provider or on the prescription label. Typically, Korsuva should be stored at room temperature, away from moisture and heat.
  • Keep the medication out of reach of children and pets.


  • Properly dispose of any unused or expired Korsuva in accordance with local regulations and guidelines.
  • It is recommended to consult with a pharmacist or local waste disposal facility to learn about the proper disposal methods for medications.

In case of emergency/overdose

  • In case of an emergency or suspected overdose, contact your local emergency services immediately or go to the nearest emergency room.
  • If possible, take the medication packaging or any relevant information with you to assist healthcare providers in treating the overdose.

What other information should I know?

  • Inform all healthcare professionals involved in your care about any medications, supplements, or herbal products you are taking, including Korsuva.
  • Attend regular check-ups and follow-up appointments with your healthcare provider to monitor your response to the medication and address any concerns.
  • If you have any questions or concerns about the medication or its usage, consult your healthcare provider or pharmacist for clarification.

Please note that this information may not cover all possible scenarios or provide the most up-to-date information. Therefore, it is crucial to consult with a healthcare professional or refer to the medication’s packaging and prescribing information for comprehensive and accurate instructions specific to your situation.

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