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Kloxxado (Generic Naloxone Nasal Spray)

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Why is this medication prescribed?

Naloxone nasal spray is prescribed for the emergency treatment of opioid overdose. Opioids are a class of drugs that include prescription painkillers like oxycodone, hydrocodone, and morphine, as well as illicit drugs like heroin. Naloxone is an opioid antagonist, which means it can rapidly reverse the effects of an opioid overdose.

During an opioid overdose, the opioids bind to certain receptors in the brain, leading to respiratory depression and potentially fatal consequences. Naloxone works by binding to the same opioid receptors and displacing the opioids, effectively blocking their effects. This helps restore normal respiration and prevents further harm or death.

The nasal spray form of naloxone is particularly useful in emergency situations because it can be easily administered by bystanders or first responders, even if they have limited medical training. The nasal spray delivers a dose of naloxone into the nasal passages, where it is absorbed into the bloodstream and quickly acts to reverse the effects of the opioid overdose.

Naloxone nasal spray is an essential tool in combating opioid overdose and has been credited with saving many lives. It is often provided to individuals at risk of opioid overdose, as well as their family members, friends, or caretakers, to have on hand in case of an emergency.

How should this medicine be used?

Naloxone nasal spray should be used as directed by a healthcare professional or according to the instructions provided with the medication. Here is a general guide on how to use naloxone nasal spray:

  • Recognize the signs of an opioid overdose: Common signs include unconsciousness, slow or shallow breathing, pinpoint pupils, and unresponsiveness to stimuli. If you suspect someone is experiencing an opioid overdose, it is important to act quickly.
  • Call for emergency medical assistance: Dial emergency services immediately or instruct someone else to do so.
  • Prepare the naloxone nasal spray: Remove the device from its packaging. Check the expiration date and make sure the medication is not discolored or expired. The naloxone nasal spray usually comes preassembled and ready for use.
  • Position the person: Place the individual on their back and ensure their airway is clear.
  • Administer the naloxone nasal spray: Hold the device with your thumb on the bottom and two fingers on the nozzle. Gently insert the nozzle into one nostril until your fingers are against the bottom of the person’s nose. Press the plunger firmly to release the spray. The medication will be absorbed through the nasal passages.
  • Observe the person: Stay with the individual and monitor their breathing and responsiveness. If there is no improvement after 2-3 minutes, administer a second dose of naloxone nasal spray, if available, following the same steps.
  • Seek medical attention: Even if the person responds to naloxone and appears to recover, it is crucial to seek medical attention immediately. Opioid overdose can have long-lasting effects, and professional medical care is necessary.

Remember, naloxone nasal spray is a temporary solution that provides time for emergency medical services to arrive. It is not a substitute for professional medical treatment.

Other uses for this medicine

Naloxone nasal spray is primarily used for the emergency treatment of opioid overdose. However, it’s important to note that naloxone has limited effectiveness in reversing overdoses caused by non-opioid drugs or certain synthetic opioids such as fentanyl. It is primarily designed to counteract the effects of traditional opioids.

What special precautions should I follow?

As for special precautions regarding naloxone nasal spray, here are some important points to consider:

  • Medical supervision: Naloxone nasal spray is typically used in emergency situations, but it is still important to seek medical assistance as soon as possible after administering the medication. It is not a substitute for professional medical care, and anyone who has experienced an overdose should still be evaluated and treated by healthcare professionals.
  • Proper training: It is recommended to receive proper training on how to recognize the signs of an opioid overdose, administer naloxone nasal spray correctly, and perform basic life support techniques, such as CPR. Many regions offer training programs or resources to help individuals understand how to respond to opioid overdoses effectively.
  • Allergic reactions: Some individuals may have an allergic reaction to naloxone. If you or someone else experiences symptoms like difficulty breathing, rash, itching, or swelling after using naloxone nasal spray, seek medical attention immediately.
  • Reversal of pain relief: Naloxone can reverse the effects of opioid pain medications, potentially causing sudden withdrawal symptoms and pain. Therefore, it is essential to use naloxone nasal spray only for its intended purpose of treating opioid overdose and not as a routine method for pain management.
  • Storage and expiration: Naloxone nasal spray should be stored at room temperature, away from excessive heat or cold. Pay attention to the expiration date and replace the medication when it expires.

It is crucial to consult with a healthcare professional or pharmacist to receive specific instructions and guidance on the use of naloxone nasal spray, as they can provide the most up-to-date information and address any individual concerns or considerations.

What special dietary instructions should I follow?

Naloxone nasal spray does not have specific dietary instructions that need to be followed. It is generally safe to use the medication with or without food. However, it is always a good idea to follow a healthy and balanced diet as recommended by healthcare professionals for overall well-being.

What should I do if I forget a dose?

If you forget a dose of naloxone nasal spray, it is important to remember that this medication is typically used in emergency situations to treat opioid overdose. It is not a medication that is used on a regular dosing schedule. If you find yourself in a situation where naloxone nasal spray needs to be administered, it is crucial to act promptly and follow the instructions provided by healthcare professionals or the product packaging.

What side effects can this medication cause?

Naloxone nasal spray is generally well-tolerated, and serious side effects are rare. However, like any medication, it can cause some side effects. Common side effects of naloxone nasal spray may include:

  • Withdrawal symptoms: Naloxone can precipitate opioid withdrawal symptoms in individuals who are physically dependent on opioids. These symptoms may include sweating, restlessness, irritability, nausea, vomiting, abdominal cramps, increased heart rate, and increased blood pressure. However, these symptoms are temporary and indicate that the naloxone is working to reverse the effects of the opioids.
  • Reversal of pain relief: Naloxone can rapidly reverse the pain-relieving effects of opioid medications, potentially leading to sudden pain or discomfort in individuals who rely on these medications for pain management. It is important to be aware of this possibility, especially if naloxone is administered to a person who is receiving opioid pain medications.

Less common side effects of naloxone nasal spray may include:

  • Headache
  • Runny nose
  • Sneezing
  • Elevated blood pressure
  • Nervousness
  • Increased heart rate
  • Fatigue
  • Dizziness
  • Body aches

It’s important to note that the side effects mentioned above are generally mild and short-lived. If you or someone else experiences any concerning or severe side effects after using naloxone nasal spray, it is important to seek medical attention promptly.

This list may not include all possible side effects. If you have concerns about specific side effects or if you experience any unexpected symptoms after using naloxone nasal spray, it is advisable to consult with a healthcare professional or pharmacist for further evaluation and guidance.

What should I know about storage and disposal of this medication?


  • Follow the storage instructions provided by the manufacturer or your healthcare provider.
  • Typically, naloxone nasal spray should be stored at room temperature, away from direct sunlight, heat, or freezing temperatures.
  • Keep it out of reach of children and pets.


  • Do not dispose of naloxone nasal spray in the regular trash or flush it down the toilet unless specifically instructed to do so.
  • Follow the proper disposal guidelines for your region, which may include returning unused naloxone to a pharmacy or participating in a drug take-back program.
  • If you are unsure about how to dispose of naloxone nasal spray, consult your pharmacist or healthcare provider.

In case of emergency/overdose

  • In the case of a suspected opioid overdose, it is crucial to call emergency services immediately (e.g., 911 in the United States) for professional medical assistance.
  • Administer naloxone nasal spray as directed by the product packaging or your healthcare provider. Usually, this involves spraying the medication into one nostril.
  • If the person does not respond within 2-3 minutes, administer a second dose if available or as directed.
  • Continue to provide rescue breaths or CPR (cardiopulmonary resuscitation) until emergency medical services arrive.
  • Even if naloxone successfully reverses the overdose, it is essential to seek medical attention to ensure the person’s safety and address any underlying health issues.

What other information should I know?

  • Naloxone nasal spray is used as an emergency response to opioid overdoses, but it is not a substitute for professional medical care. Always seek medical attention after administering naloxone.
  • Inform your healthcare provider if you have any known allergies or medical conditions before using naloxone nasal spray.
  • Familiarize yourself with the product instructions and become comfortable with how to use the nasal spray correctly before an emergency arises.
  • Be aware of the signs of an opioid overdose, such as shallow or stopped breathing, pinpoint pupils, unresponsiveness, and pale or clammy skin.
  • Naloxone nasal spray may have potential side effects, such as withdrawal symptoms or increased heart rate. Report any adverse reactions to your healthcare provider.

Remember, it is essential to consult with your healthcare provider or pharmacist for specific instructions regarding the storage, disposal, and use of naloxone nasal spray.

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