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Kisqali (Generic Ribociclib)

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Why is this medication prescribed?

Kisqali (generic name ribociclib) is a prescription medication that is primarily used in the treatment of certain types of breast cancer. It belongs to a class of drugs called cyclin-dependent kinase 4/6 (CDK4/6) inhibitors.

Kisqali is prescribed for postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced or metastatic breast cancer. It is used in combination with an aromatase inhibitor, which is another type of medication that blocks the production of estrogen, or with fulvestrant, a selective estrogen receptor degrader.

The main goal of Kisqali treatment is to slow down or stop the growth of cancer cells by inhibiting CDK4/6 enzymes. These enzymes play a crucial role in promoting cell division and growth, and by blocking them, Kisqali helps to prevent cancer cells from multiplying rapidly.

Kisqali is typically prescribed as part of a comprehensive treatment plan for breast cancer, which may also include surgery, radiation therapy, and other medications. The specific treatment regimen depends on various factors, such as the stage of cancer, the presence of other health conditions, and individual patient characteristics. It is important to consult with a healthcare professional for personalized medical advice and information about the appropriate use of Kisqali.

How should this medicine be used?

Kisqali (ribociclib) is available in the form of tablets and should be taken orally. The dosing and administration instructions for Kisqali may vary depending on the specific treatment regimen and individual patient factors. It is essential to follow the instructions provided by your healthcare provider. Here are some general guidelines:

  • Kisqali is usually taken once daily for 21 consecutive days, followed by a 7-day break. This 28-day period is considered one treatment cycle.
  • The recommended dose of Kisqali is typically 600 mg taken orally (three 200 mg tablets) once daily with or without food. However, the exact dosage may differ based on your specific situation, so it’s important to follow your doctor’s instructions.
  • Swallow the tablets whole with a glass of water. Do not crush, chew, or break them.
  • It’s advisable to take Kisqali at the same time each day to maintain a consistent level of the medication in your body.
  • If you miss a dose of Kisqali, you should take it as soon as you remember, as long as it is within 12 hours of your usual dosing time. If more than 12 hours have passed, it’s recommended to skip the missed dose and resume the regular dosing schedule the next day. Do not take a double dose to make up for a missed one.
  • During the treatment, your healthcare provider may perform regular blood tests to monitor your blood cell counts and other parameters. Follow up with your doctor for the recommended monitoring schedule.

It’s crucial to discuss any specific instructions or concerns about the use of Kisqali with your healthcare provider. They will provide you with comprehensive guidance tailored to your individual needs and circumstances.

Other uses for this medicine

Kisqali (ribociclib) is primarily used for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced or metastatic breast cancer in postmenopausal women. It is typically prescribed in combination with other medications, such as aromatase inhibitors or fulvestrant, as part of a comprehensive treatment plan for breast cancer.

What special precautions should I follow?

Regarding special precautions, it is crucial to consider the following:

  • Before starting Kisqali, inform your healthcare provider about all your medical conditions, including any history of liver problems, heart disease, or any other significant health issues.
  • Kisqali can potentially cause serious or life-threatening liver problems. Regular monitoring of liver function through blood tests is necessary during treatment. Inform your doctor immediately if you experience symptoms such as yellowing of the skin or eyes (jaundice), dark urine, unusual fatigue, or abdominal pain.
  • Kisqali may cause a decrease in the number of white blood cells, which can increase the risk of infection. Regular blood tests will be conducted to monitor your blood cell counts. Inform your doctor if you experience signs of infection, such as fever, chills, sore throat, or any other symptoms.
  • Certain medications, including those metabolized by the liver enzyme CYP3A4, may interact with Kisqali. It’s important to inform your healthcare provider about all the medications, supplements, or herbal products you are taking or plan to take during treatment.
  • Kisqali may cause QT interval prolongation, which can lead to an irregular heart rhythm. Inform your doctor if you have a history of heart problems or if you are taking any medications that can affect heart rhythm.
  • Women who are pregnant or breastfeeding should not take Kisqali, as it may cause harm to the unborn baby or pass into breast milk.

These are general precautions, and individual circumstances may require additional precautions or considerations. Always consult your healthcare provider for personalized advice and information specific to your situation when using Kisqali or any other medication.

What special dietary instructions should I follow?

As for dietary instructions, there are no specific dietary restrictions associated with Kisqali. However, it is generally advisable to maintain a healthy and balanced diet while undergoing cancer treatment. A registered dietitian can provide personalized recommendations based on your specific needs.

What should I do if I forget a dose?

If you forget to take a dose of Kisqali, it is recommended to take the missed dose as soon as you remember, as long as it is within 12 hours of the usual dosing time. If more than 12 hours have passed, it is best to skip the missed dose and take the next scheduled dose at the regular time. It is important not to take a double dose to make up for a missed one.

What side effects can this medication cause?

Kisqali (ribociclib) may cause side effects, which can vary in severity and individual response. It’s important to note that not all individuals will experience these side effects, and some may experience different side effects not listed here. If you have concerns about potential side effects, it’s advisable to discuss them with your healthcare provider. Common side effects associated with Kisqali include:

  • Neutropenia: A decrease in the number of white blood cells called neutrophils, which can increase the risk of infection.
  • Leukopenia: A decrease in the number of white blood cells in general.
  • Fatigue: Feeling tired, weak, or lacking energy.
  • Nausea: Feeling the urge to vomit or discomfort in the stomach.
  • Diarrhea: Loose or watery stools.
  • Headache: A pain or discomfort in the head or neck region.
  • Vomiting: Act of forcefully expelling the stomach’s contents through the mouth.
  • Constipation: Difficulty in passing stools or infrequent bowel movements.
  • Hair loss or thinning: Some individuals may experience hair loss or thinning during treatment.
  • Increased risk of infection: Due to decreased white blood cell counts, there is an increased susceptibility to infections.
  • QT interval prolongation: Kisqali may cause changes in the electrical activity of the heart, leading to an irregular heartbeat.

These are not all the possible side effects of Kisqali. If you experience any concerning or persistent side effects while taking Kisqali, it is important to notify your healthcare provider promptly. They can provide further guidance, monitor your condition, and suggest appropriate measures to manage the side effects.

It’s worth noting that this is a general overview, and individual experiences may vary. Your healthcare provider can provide more detailed information about the potential side effects of Kisqali based on your specific situation.

What should I know about storage and disposal of this medication?

  • Storage: Keep Kisqali tablets in their original packaging at room temperature, typically between 20°C to 25°C (68°F to 77°F). Protect the medication from excessive moisture and light. Do not store it in the bathroom or any location with high humidity.
  • Keep out of reach of children and pets: Store Kisqali in a secure place out of the reach of children and pets to prevent accidental ingestion or misuse.
  • Disposal: Properly dispose of any unused or expired Kisqali tablets. Do not flush them down the toilet or throw them in the trash. Instead, consult your healthcare provider, local pharmacy, or designated drug disposal program for specific instructions on safe medication disposal.

In case of emergency/overdose

  • Contact emergency services: Call your local emergency number or go to the nearest emergency room immediately if you or someone else has taken more Kisqali tablets than prescribed or in case of a medical emergency.
  • Inform healthcare professionals: Provide healthcare providers with details about the medication involved, including the name (ribociclib/Kisqali), dosage, and any other relevant information.
  • Follow medical advice: Follow the instructions and advice given by healthcare professionals regarding the emergency situation or overdose. They will provide appropriate treatment based on the specific circumstances.

What other information should I know?

  • Regular check-ups and monitoring: Your healthcare provider will schedule regular check-ups and perform blood tests to monitor your progress, check for any side effects, and evaluate the effectiveness of Kisqali. Attend these appointments as advised.
  • Compliance with dosing schedule: It is important to take Kisqali as prescribed by your healthcare provider. Follow the recommended dosing schedule and do not change the dosage or frequency without consulting your doctor.
  • Informing other healthcare providers: Ensure that all healthcare professionals involved in your care, including specialists or dentists, are aware that you are taking Kisqali. This information is essential for the coordination of your overall treatment and prevention of potential drug interactions.
  • Additional medications and supplements: Inform your healthcare provider about all other prescription medications, over-the-counter drugs, supplements, or herbal products you are taking. Some medications or supplements may interact with Kisqali, potentially affecting its effectiveness or increasing the risk of side effects.
  • Pregnancy and breastfeeding: Kisqali may harm unborn babies and is not recommended during pregnancy. It is important to use effective contraception during treatment and for a certain period after discontinuing Kisqali. Inform your doctor if you are pregnant or planning to become pregnant. Additionally, it is advised not to breastfeed while taking Kisqali, as it may pass into breast milk.

Remember, the information provided here is not exhaustive, and it’s crucial to consult your healthcare provider or read the medication guide provided with Kisqali for complete and up-to-date instructions, precautions, and information specific to your situation.

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