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Janumet (Generic Sitagliptin)

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Why is this medication prescribed?

Sitagliptin is prescribed primarily for the management of type 2 diabetes. It is used to help control high blood sugar levels in individuals with this condition. Here are the main reasons why Sitagliptin is prescribed:

  • Type 2 diabetes: Sitagliptin is commonly prescribed as a monotherapy or in combination with other diabetes medications for the treatment of type 2 diabetes. It is used when diet and exercise alone are not sufficient to control blood sugar levels.
  • Blood sugar regulation: Sitagliptin belongs to the class of medications called DPP-4 inhibitors. It works by increasing the levels of incretin hormones in the body. These hormones help regulate blood sugar levels by stimulating the release of insulin and reducing the production of glucagon.
  • Insulin secretion: Sitagliptin enhances the secretion of insulin by the pancreas in response to meals. This helps to lower blood sugar levels after eating and maintain more stable glucose control throughout the day.
  • Glucagon inhibition: Sitagliptin also inhibits the production of glucagon, a hormone that raises blood sugar levels. By reducing the amount of glucagon released by the pancreas, Sitagliptin helps to prevent excess glucose production in the liver.

Overall, Sitagliptin is prescribed to improve glycemic control and reduce the risk of complications associated with high blood sugar levels in individuals with type 2 diabetes. It is usually used as part of a comprehensive treatment plan that includes a healthy diet, regular exercise, and other diabetes management strategies. The specific prescription and dosing of Sitagliptin may vary depending on individual factors and should be determined by a healthcare provider.

How should this medicine be used?

Here are some key points to consider regarding the use of Sitagliptin:

  • Dosage: The dosage of Sitagliptin may vary depending on individual factors such as age, kidney function, and other medications being taken. It is important to follow the prescribed dosage provided by your healthcare provider.
  • Administration: Sitagliptin is typically taken orally in the form of tablets. It can be taken with or without food.
  • Timing: The frequency of Sitagliptin administration is usually once daily. It is important to take it around the same time each day to maintain consistent levels of the medication in the body.
  • Follow instructions: Always follow the instructions provided by your healthcare provider or the directions on the prescription label. Do not alter the dosage or frequency without consulting your doctor.

Always consult your healthcare provider for personalized advice on the appropriate use of Sitagliptin based on your specific medical condition.

Other uses for this medicine

Sitagliptin is primarily used for the management of type 2 diabetes. However, it is important to note that the approved uses of medications may change over time. As of my knowledge cutoff in September 2021, Sitagliptin is primarily prescribed for type 2 diabetes and its use for other conditions may be off-label or under investigation.

What special precautions should I follow?

Regarding special precautions when using Sitagliptin, here are some important considerations:

  • Allergies: Inform your healthcare provider if you have a known allergy or hypersensitivity to Sitagliptin or any other DPP-4 inhibitor. Discuss any allergic reactions you may have experienced with medications, including skin rash, itching, swelling, or difficulty breathing.
  • Kidney function: If you have impaired kidney function or are undergoing dialysis, your healthcare provider may need to adjust the dosage of Sitagliptin. Sitagliptin is primarily eliminated through the kidneys, so dose adjustment is necessary to avoid excessive accumulation of the medication.
  • Pancreatitis: Inform your doctor if you have a history of pancreatitis or gallstones, as Sitagliptin has been associated with an increased risk of pancreatitis. Seek medical attention immediately if you experience severe abdominal pain that may be accompanied by nausea and vomiting.
  • Hypoglycemia: Sitagliptin by itself does not usually cause hypoglycemia (low blood sugar), but when used in combination with certain other diabetes medications like insulin or sulfonylureas, the risk of hypoglycemia may increase. It is important to closely monitor your blood sugar levels and be aware of the signs and symptoms of hypoglycemia.
  • Pregnancy and breastfeeding: The safety of Sitagliptin during pregnancy and breastfeeding has not been well established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Sitagliptin with your healthcare provider.
  • Drug interactions: Inform your doctor about all the medications, including prescription, over-the-counter drugs, and supplements, that you are taking. Sitagliptin may interact with certain medications, such as other antidiabetic agents or medications that affect renal function. Your doctor can help determine the compatibility of Sitagliptin with other medications you are using.

These precautions are not exhaustive, and it is important to consult with your healthcare provider or pharmacist for specific guidance based on your medical history and individual circumstances. They can provide you with the most up-to-date information and advise you on the appropriate use of Sitagliptin.

What special dietary instructions should I follow?

Sitagliptin is a medication used to treat type 2 diabetes. It belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, which help regulate blood sugar levels. When taking Sitagliptin, there are no specific dietary restrictions you need to follow. However, it’s generally recommended to maintain a healthy and balanced diet that aligns with the guidelines provided by your healthcare provider or dietitian for managing diabetes.

What should I do if I forget a dose?

If you forget to take a dose of Sitagliptin, you should take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, it’s advisable to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. It’s important to consult your healthcare provider for specific instructions regarding missed doses, as they can provide you with the best guidance based on your individual circumstances.

What side effects can this medication cause?

Sitagliptin is a medication commonly prescribed for the treatment of type 2 diabetes. Like any medication, it can potentially cause side effects. Here are some of the possible side effects associated with Sitagliptin:

  1. Common side effects:
    • Upper respiratory tract infection
    • Headache
    • Nasopharyngitis (inflammation of the nose and throat)
    • Diarrhea
    • Nausea
    • Stomach pain
    • Hypoglycemia (low blood sugar) when used in combination with certain other diabetes medications like insulin or sulfonylureas
  2. Uncommon side effects:
    • Dizziness
    • Fatigue
    • Skin reactions such as rash or itching
    • Joint pain
    • Back pain
    • Pancreatitis (inflammation of the pancreas)
  3. Rare but serious side effects:
    • Allergic reactions, including swelling of the face, lips, tongue, or throat, and difficulty breathing or swallowing
    • Severe joint pain
    • Bullous pemphigoid (a rare autoimmune skin disorder characterized by blisters)

It is important to note that not everyone will experience these side effects, and some individuals may experience no side effects at all. If you are prescribed Sitagliptin and experience any unusual or severe side effects, it is important to contact your healthcare provider for further evaluation and guidance.

What should I know about storage and disposal of this medication?

When it comes to storage and disposal of Sitagliptin, here are some important guidelines to keep in mind:

  • Storage: Store Sitagliptin at room temperature, away from excessive heat, moisture, and direct light. Follow the specific storage instructions provided on the medication’s packaging or as directed by your healthcare provider.
  • Disposal: It’s essential to dispose of medications properly to prevent misuse or harm to others. Follow local regulations or consult with your pharmacist on how to safely dispose of Sitagliptin when you no longer need it or when it expires. Do not flush it down the toilet or pour it into drains unless instructed to do so.

In case of emergency/overdose

In case of an emergency or overdose, take the following steps:

  • If you experience severe symptoms or have concerns about an overdose, call your local emergency services immediately or go to the nearest emergency room.
  • Contact a poison control center or your healthcare provider for further guidance on what steps to take. You can reach poison control centers in your country by calling the national helpline.

What other information should I know?

When discussing Sitagliptin with your healthcare provider, it’s important to inform them about your medical history, including any allergies, other medical conditions you have, and medications you are currently taking. This information will help your healthcare provider make informed decisions about your treatment plan and ensure Sitagliptin is suitable for you.

Additionally, be sure to follow your healthcare provider’s instructions regarding regular check-ups and monitoring of your blood sugar levels to ensure the medication is effectively managing your condition. If you experience any new or worsening symptoms or have concerns about Sitagliptin, consult your healthcare provider for further evaluation and guidance.

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