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Ixekizumab Injection

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Why is this medication prescribed?

Ixekizumab injection is prescribed for the treatment of certain inflammatory conditions, primarily:

  • Plaque Psoriasis: Ixekizumab is FDA-approved for the treatment of moderate to severe plaque psoriasis in adults. Plaque psoriasis is a chronic autoimmune disease that causes the rapid buildup of skin cells, leading to thick, red, and scaly patches on the skin. Ixekizumab helps to reduce the inflammation associated with psoriasis, improving skin symptoms such as redness, itching, and scaling.
  • Psoriatic Arthritis: Ixekizumab is also used to treat psoriatic arthritis, which is a type of arthritis that affects some people with psoriasis. Psoriatic arthritis causes joint pain, stiffness, and swelling. By targeting the inflammatory pathways involved in the disease, Ixekizumab can help reduce the symptoms of psoriatic arthritis and improve joint function.
  • Axial Spondyloarthritis: Ixekizumab is prescribed for the treatment of axial spondyloarthritis, specifically ankylosing spondylitis. Axial spondyloarthritis is a chronic inflammatory condition that primarily affects the spine and sacroiliac joints, leading to pain, stiffness, and limited mobility. Ixekizumab can help alleviate the symptoms associated with axial spondyloarthritis and improve overall quality of life.

How should this medicine be used?

Ixekizumab injection is typically used as a self-administered medication, and it is important to follow the instructions provided by your healthcare provider and the medication guide. Here are some general guidelines on how Ixekizumab injection should be used:

  • Administration: Ixekizumab is given as a subcutaneous injection, which means it is injected just beneath the skin. The injection site can be the front of the thighs, abdomen (except for the 2-inch area around the navel), or outer area of the upper arms. Your healthcare provider will provide specific instructions on the injection technique.
  • Training: Before self-administering Ixekizumab, it is essential to receive proper training from a healthcare professional. They will guide you on how to prepare and administer the injection safely. Make sure to ask any questions or address any concerns during this training session.
  • Dosing: The dosing schedule for Ixekizumab may vary depending on the condition being treated. For plaque psoriasis, the usual dose is an initial loading dose, followed by maintenance doses. The loading dose is typically two injections, and the maintenance dose is given every 4 weeks. For psoriatic arthritis and axial spondyloarthritis, the dosing schedule may be different. It’s crucial to follow your healthcare provider’s prescribed dosing instructions.
  • Storage: Ixekizumab injections should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). Do not freeze the medication. If needed, it can be stored at room temperature (up to 77°F or 25°C) for a maximum of 7 days. Once removed from the refrigerator or opened, it should not be returned for refrigeration.
  • Adherence: It is important to follow the prescribed dosing schedule and not miss any doses. If you have any concerns about the medication or need to adjust the dosing schedule, consult your healthcare provider before making any changes.

Always consult with your healthcare provider or refer to the specific instructions provided with the medication for precise administration guidelines. They can provide personalized guidance and address any specific concerns or questions you may have.

Other uses for this medicine

Ixekizumab injection is primarily used for the treatment of plaque psoriasis, psoriatic arthritis, and axial spondyloarthritis. Ask your doctor or pharmacist for more details if you believe this drug may be recommended for another purpose.

What special precautions should I follow?

Regarding special precautions to follow when using Ixekizumab injection, it’s important to consider the following:

  • Infections: Ixekizumab can affect the immune system, which may increase the risk of infections. Before starting treatment, inform your healthcare provider about any existing infections or if you have a history of recurrent infections. It’s important to avoid using Ixekizumab if you have an active infection, including localized skin infections.
  • Tuberculosis (TB): Prior to initiating Ixekizumab, it is necessary to be screened for latent tuberculosis (TB) infection. If you have a history of TB or are at high risk for TB, additional precautions may be needed.
  • Vaccinations: It is recommended to bring your vaccinations up to date before starting Ixekizumab treatment. However, live vaccines should be avoided while on Ixekizumab therapy.
  • Allergic Reactions: If you have experienced allergic reactions or serious hypersensitivity to Ixekizumab or any of its components, inform your healthcare provider. Signs of an allergic reaction may include difficulty breathing, swelling of the face, lips, tongue, or throat, or rash.
  • Pregnancy and Breastfeeding: It is important to discuss the potential risks and benefits of Ixekizumab with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Ixekizumab during pregnancy or breastfeeding is typically not recommended unless the potential benefits outweigh the risks.
  • Other Medical Conditions: Inform your healthcare provider about any other medical conditions you have, including a history of inflammatory bowel disease, Crohn’s disease, or ulcerative colitis, as Ixekizumab may worsen these conditions.
  • Monitoring: Regular monitoring, including blood tests, may be necessary while on Ixekizumab to evaluate the response to treatment and monitor for potential side effects.

It is crucial to consult with your healthcare provider for personalized advice and guidance based on your specific medical history and condition. They can provide you with detailed information on the precautions, potential side effects, and interactions associated with Ixekizumab injection.

What special dietary instructions should I follow?

Ixekizumab is a medication used to treat certain inflammatory conditions, such as psoriasis and psoriatic arthritis. While there are no specific dietary restrictions associated with Ixekizumab, it’s always a good idea to maintain a healthy and balanced diet. Eating a variety of nutritious foods can support your overall well-being and potentially contribute to better treatment outcomes.

What should I do if I forget a dose?

If you forget to take a dose of Ixekizumab, you should contact your healthcare provider for guidance. They will be able to provide specific instructions based on your treatment plan. It’s generally important to follow the prescribed dosing schedule for optimal results, but your healthcare provider can advise you on the best course of action if you miss a dose.

What side effects can this medication cause?

Ixekizumab is a medication used to treat certain autoimmune conditions such as plaque psoriasis and psoriatic arthritis. Like any medication, it can have potential side effects. Here are some of the commonly reported side effects associated with Ixekizumab injection:

  • Injection site reactions: This is the most common side effect, including pain, redness, itching, swelling, or bruising at the injection site.
  • Upper respiratory tract infections: Symptoms may include a sore throat, stuffy or runny nose, and sinus congestion.
  • Nasopharyngitis: It refers to inflammation of the nose and throat, which may cause symptoms such as a stuffy or runny nose, sore throat, or cough.
  • Headache: Some people may experience mild to moderate headaches.
  • Nausea: It is possible to experience feelings of nausea or an upset stomach.
  • Diarrhea: Some individuals may experience loose stools or increased bowel movements.
  • Tinea infections: These are fungal infections of the skin, commonly known as ringworm. Symptoms may include red, itchy, and scaly patches on the skin.
  • Allergic reactions: Although rare, allergic reactions can occur. Signs may include rash, itching, swelling, dizziness, and difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.

It’s important to note that not everyone will experience these side effects, and some individuals may have different reactions to the medication. If you are considering Ixekizumab treatment, it is best to consult with a healthcare professional who can provide you with more specific information based on your individual medical history and condition.

What should I know about storage and disposal of this medication?


  • Keep Ixekizumab in the refrigerator between a temperature of 2°C to 8°C (36°F to 46°F).
  • Do not freeze the medication.
  • Keep the medication in the original carton to protect it from light.
  • If needed, Ixekizumab can be stored at room temperature (up to 25°C or 77°F) for up to 30 days.
  • Once removed from the refrigerator, do not put it back.


  • Unused or expired Ixekizumab should be disposed of properly.
  • Follow your local guidelines or regulations for the disposal of unused medications.
  • Do not dispose of Ixekizumab in household trash or flush it down the toilet unless instructed to do so by your healthcare provider or local waste disposal authority.

In case of emergency/overdose

  • If you experience severe side effects or an overdose, immediately seek medical attention or call your local emergency helpline.
  • It is important to provide healthcare professionals with as much information as possible, including the name of the medication (Ixekizumab), the strength, and the amount taken.

What other information should I know?

  • Ixekizumab is given as an injection under the skin (subcutaneous injection) and should only be administered by a healthcare professional or as instructed by your doctor.
  • Inform your healthcare provider about any allergies, medical conditions, or medications you are taking before starting Ixekizumab.
  • Follow your healthcare provider’s instructions for the proper use of Ixekizumab, including the recommended dosage and injection technique.
  • Regularly monitor your condition and attend follow-up appointments with your healthcare provider to assess the effectiveness and safety of Ixekizumab.
  • Inform your healthcare provider immediately if you experience any new or worsening symptoms while using Ixekizumab.
  • It is important to disclose your pregnancy status or plans for pregnancy, as the safety of Ixekizumab during pregnancy and breastfeeding has not been established.

Remember, this information is meant as a general guide, and it is always best to consult your healthcare provider or pharmacist for specific instructions and advice regarding the storage, disposal, and use of Ixekizumab.

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