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Isavuconazonium Injection

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Why is this medication prescribed?

Isavuconazonium injection is a medication used for the treatment of invasive aspergillosis and invasive mucormycosis, which are serious fungal infections. These infections typically occur in individuals with weakened immune systems, such as those undergoing chemotherapy, organ transplantation, or with HIV/AIDS. Isavuconazonium injection is an antifungal medication that works by inhibiting the growth and reproduction of certain fungi. It is usually prescribed when other antifungal treatments have not been effective or cannot be tolerated.

How should this medicine be used?

Isavuconazonium Injection is a medication that is administered through a vein (intravenous infusion) by a healthcare professional. The dosage and duration of treatment will be determined by your healthcare provider based on factors such as the specific fungal infection being treated, the severity of the infection, and your overall health.

The injection should be given over a period of 1 to 3 hours. The exact infusion time will depend on the dose and the healthcare provider’s instructions. During the infusion, you will be monitored closely by a healthcare professional to ensure that there are no adverse reactions or complications.

It is important to follow the instructions provided by your healthcare provider regarding the dosage and treatment schedule. Do not adjust the dosage or stop the treatment without consulting your healthcare provider. Even if you start to feel better, it is essential to complete the full course of treatment as prescribed to effectively treat the fungal infection.

If you have any specific questions or concerns about the administration of Isavuconazonium Injection, it is best to discuss them with your healthcare provider or the healthcare professional administering the medication. They will be able to provide you with detailed instructions and address any concerns you may have.

Other uses for this medicine

Isavuconazonium Injection may also have off-label or investigational uses for other fungal infections. However, the decision to use Isavuconazonium for conditions other than invasive aspergillosis or invasive mucormycosis should be made by a qualified healthcare professional based on individual patient factors.

What special precautions should I follow?

When using Isavuconazonium Injection, there are several special precautions to consider. These precautions include:

  • Allergies: Inform your healthcare provider if you have any known allergies to Isavuconazonium or any other antifungal medications.
  • Liver function: Isavuconazonium can potentially cause liver damage. It is important to monitor liver function regularly during treatment and discontinue the medication if liver abnormalities occur.
  • Drug interactions: Isavuconazonium may interact with other medications, including certain antibiotics, antivirals, antifungals, and certain medications that affect liver enzymes. Inform your healthcare provider about all the medications you are taking to avoid potential interactions.
  • Pregnancy and breastfeeding: The use of Isavuconazonium during pregnancy or breastfeeding is not well-studied. It is important to discuss the risks and benefits with your healthcare provider if you are pregnant or breastfeeding.
  • Potential side effects: Isavuconazonium may cause side effects such as nausea, vomiting, diarrhea, headache, and abnormal liver function tests. If you experience any severe or persistent side effects, notify your healthcare provider.
  • Pre-existing medical conditions: Inform your healthcare provider if you have any pre-existing medical conditions, especially liver or kidney problems, as Isavuconazonium dosage adjustments may be required.
  • Other medications: Provide a complete list of all medications, including over-the-counter drugs and herbal supplements, to your healthcare provider before starting Isavuconazonium treatment.

It is crucial to follow your healthcare provider’s instructions and recommendations regarding the use of Isavuconazonium Injection and to seek medical advice if you have any concerns or questions.

What special dietary instructions should I follow?

Isavuconazonium Injection does not typically have specific dietary instructions. However, it’s always important to follow a balanced and healthy diet to support your overall health and well-being during treatment with any medication. You should consult with your healthcare provider or a registered dietitian for personalized dietary recommendations based on your specific medical condition and needs.

What should I do if I forget a dose?

If you forget a dose of Isavuconazonium Injection, it is important to contact your healthcare provider or healthcare professional immediately for guidance. They will provide instructions on whether to take the missed dose or adjust your dosing schedule. It is generally recommended not to double the dose to make up for a missed one unless specifically advised by your healthcare provider.

What side effects can this medication cause?

Like any medication, it can potentially cause side effects. Here are some possible side effects associated with Isavuconazonium injection:

  • Nausea and vomiting: These are common side effects and may occur during or after the administration of the injection. Taking the medication with food can help reduce these symptoms.
  • Diarrhea: Isavuconazonium injection may cause diarrhea in some individuals. It is important to stay hydrated and notify your healthcare provider if the diarrhea persists or becomes severe.
  • Headache: Headaches are a possible side effect of Isavuconazonium injection. If the headaches are severe or persistent, it is advisable to consult your healthcare provider.
  • Abnormal liver function: Isavuconazonium injection may affect liver function in some individuals. Regular monitoring of liver enzymes may be necessary during treatment.
  • Rash or allergic reactions: Skin rashes and allergic reactions, such as itching, hives, or swelling, can occur with the use of Isavuconazonium injection. If you experience any signs of an allergic reaction, seek immediate medical attention.
  • Abnormal kidney function: Isavuconazonium injection may affect kidney function in some cases. Monitoring of kidney function may be required during treatment.
  • Changes in blood electrolyte levels: Isavuconazonium injection may cause changes in blood electrolyte levels, such as potassium and magnesium. Regular monitoring may be necessary, especially in individuals with underlying electrolyte imbalances.
  • Injection site reactions: Pain, redness, swelling, or irritation at the site of injection may occur.

It is important to note that not everyone will experience these side effects, and some individuals may experience different or no side effects at all. If you have any concerns or experience severe or persistent side effects, it is recommended to consult your healthcare provider for further guidance.

What should I know about storage and disposal of this medication?


  • Isavuconazonium Injection should be stored in a refrigerator between 2°C to 8°C (36°F to 46°F).
  • Do not freeze the medication.
  • Protect the vials from light by storing them in the original packaging.
  • Keep Isavuconazonium Injection out of the reach of children and pets.


  • Properly dispose of any unused or expired medication.
  • Follow your local guidelines or regulations for medication disposal.
  • Do not dispose of medications in household waste or flush them down the toilet or drain unless instructed to do so.

In case of emergency/overdose

  • In case of an emergency or suspected overdose, call your local emergency services immediately.
  • Contact a poison control center or seek medical attention promptly.
  • Provide healthcare professionals with as much information as possible, including the quantity of medication taken and the time of ingestion.

What other information should I know?

  • Isavuconazonium Injection should only be administered under the supervision of a healthcare professional experienced in the management of invasive fungal infections.
  • Inform your healthcare provider about any allergies or sensitivities you may have, as well as any other medications, supplements, or herbal products you are taking.
  • Report any side effects or adverse reactions to your healthcare provider.
  • Isavuconazonium Injection may interact with other medications, so it’s important to discuss your current medication regimen with your healthcare provider.
  • Follow the prescribed dosing instructions and complete the full course of treatment unless otherwise directed by your healthcare provider.
  • Do not stop taking Isavuconazonium Injection without consulting your healthcare provider.

Please note that this information is not exhaustive, and it’s essential to consult the medication’s package insert or your healthcare provider for complete and up-to-date instructions and guidance regarding the storage, disposal, and handling of Isavuconazonium Injection.

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