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Invagesic (Generic Orphenadrine)

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Why is this medication prescribed?

Orphenadrine is a medication that is primarily prescribed for the treatment of muscle spasms and associated pain. It is classified as a skeletal muscle relaxant and belongs to a group of drugs known as anticholinergics.

Orphenadrine is commonly used to relieve muscle spasms and stiffness caused by conditions such as:

  • Muscle strains: It can be prescribed to alleviate muscle spasms and discomfort associated with injuries, such as strains or sprains.
  • Musculoskeletal conditions: Orphenadrine may be used in the treatment of musculoskeletal disorders like fibromyalgia, myofascial pain syndrome, or rheumatoid arthritis, to help reduce muscle spasms and pain.
  • Neurological disorders: It can also be prescribed for certain neurological conditions, such as Parkinson’s disease or dystonia, to help manage muscle spasms or tremors associated with these disorders.

Orphenadrine works by blocking the action of acetylcholine, a neurotransmitter involved in muscle contractions. By inhibiting the effects of acetylcholine, it helps to reduce muscle spasms and provide relief from associated pain and discomfort.

How should this medicine be used?

Orphenadrine is taken orally in the form of tablets or extended-release capsules. The dosage and frequency of administration may vary depending on factors such as the individual’s age, medical condition, and response to the treatment. It is crucial to follow the instructions provided by your healthcare provider or the dosage guidelines on the medication label.

Here are some general guidelines:

  • Follow the prescribed dosage: Take Orphenadrine exactly as prescribed by your doctor. Do not take more or less than the recommended dose unless instructed to do so by a healthcare professional.
  • Take with or without food: Orphenadrine can be taken with or without food. However, taking it with food may help minimize stomach upset.
  • Swallow the tablets or capsules whole: Do not crush, chew, or break them unless specifically instructed to do so by your healthcare provider.
  • Stick to the prescribed schedule: Take Orphenadrine at the same time(s) each day to maintain a consistent level of the medication in your body.
  • Do not abruptly stop taking Orphenadrine: If you need to discontinue the medication, consult your doctor, as a gradual reduction of the dosage may be necessary to prevent withdrawal symptoms.
  • Be aware of potential side effects: Orphenadrine may cause side effects such as drowsiness, dizziness, dry mouth, blurred vision, or constipation. If these side effects persist or worsen, inform your doctor.
  • Avoid alcohol and other sedatives: Orphenadrine can enhance the effects of alcohol and other central nervous system depressants. It is generally advisable to avoid or limit alcohol consumption while taking this medication.

Remember, it is crucial to consult a healthcare professional for personalized advice regarding the appropriate use of Orphenadrine.

Other uses for this medicine

It may also have other off-label uses, depending on the prescribing doctor’s discretion. Some of these potential off-label uses include:

  • Treatment of Parkinson’s disease: Orphenadrine may be used in combination with other medications to manage the symptoms of Parkinson’s disease, such as tremors and muscle stiffness.
  • Adjunctive therapy for chronic pain: It can be prescribed as an adjunctive therapy for chronic pain conditions like fibromyalgia, where muscle spasms contribute to the overall pain.
  • Migraine headache management: In some cases, Orphenadrine may be used to alleviate the muscle tension associated with migraines, helping to reduce the intensity and frequency of headaches.
  • Restless Legs Syndrome (RLS): Orphenadrine might be considered as part of the treatment plan for individuals with RLS who experience muscle spasms or involuntary leg movements.
  • Off-label uses in certain psychiatric conditions: Orphenadrine has been used experimentally as an adjunctive treatment for conditions like depression, anxiety, and bipolar disorder. However, its efficacy for these purposes is not well-established, and other more targeted medications are typically preferred.

What special precautions should I follow?

When using Orphenadrine, it is essential to take certain precautions to ensure safe and effective use. Here are some special precautions to consider:

  • Allergies: Inform your healthcare provider if you have any known allergies to Orphenadrine or other medications, as well as any other substances like food, preservatives, or dyes.
  • Medical history: Disclose your complete medical history to your doctor, particularly if you have a history of glaucoma, enlarged prostate, urinary retention, stomach/intestinal blockage, myasthenia gravis, or liver or kidney disease.
  • Interactions: Orphenadrine may interact with certain medications, including antihistamines, tranquilizers, sedatives, psychiatric medicines, and monoamine oxidase inhibitors (MAOIs). Provide a comprehensive list of all medications, supplements, and herbal products you are taking to your healthcare provider.
  • Pregnancy and breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Orphenadrine during pregnancy and lactation has not been well-established.
  • Driving and operating machinery: Orphenadrine can cause drowsiness, dizziness, or blurred vision. Avoid driving, operating machinery, or performing tasks requiring alertness until you understand how the medication affects you.
  • Alcohol and other depressants: Avoid consuming alcohol or using other central nervous system depressants while taking Orphenadrine, as it can enhance the sedative effects and increase the risk of side effects.

It is crucial to follow your healthcare provider’s instructions and dosage recommendations precisely and to report any concerning side effects or reactions promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Orphenadrine. However, it is always a good idea to follow a balanced and healthy diet to support overall well-being and medication effectiveness.

What should I do if I forget a dose?

Regarding missed doses, if you forget to take a dose of Orphenadrine, it is generally recommended to take it as soon as you remember. However, if it is close to the time for your next scheduled dose, it is advisable to skip the missed dose and resume your regular dosing schedule. It is important not to take a double dose to make up for the missed one, as it may increase the risk of side effects.

What side effects can this medication cause?

Orphenadrine is a medication used primarily as a muscle relaxant. Like any medication, it can cause side effects. Common side effects of orphenadrine include:

  • Dry mouth: Orphenadrine can reduce saliva production, leading to a dry mouth sensation. It is advisable to drink plenty of fluids to alleviate this symptom.
  • Blurred vision: Orphenadrine may affect vision by causing blurred or double vision. It is important to avoid activities such as driving or operating machinery that require clear vision while taking this medication.
  • Drowsiness: Orphenadrine has sedative properties and can cause drowsiness or dizziness. It is recommended to avoid activities that require alertness until you know how the medication affects you.
  • Constipation: Orphenadrine can slow down the movement of the digestive system, leading to constipation. Drinking enough water, eating a fiber-rich diet, and engaging in regular physical activity can help prevent or relieve constipation.
  • Urinary retention: Orphenadrine can interfere with bladder function, leading to difficulty urinating or incomplete emptying of the bladder. If you experience any changes in urination while taking this medication, it is important to consult your healthcare provider.
  • Nervousness or excitability: Some individuals may experience restlessness, nervousness, or excitability as a side effect of orphenadrine. If these symptoms are bothersome or persistent, it is advisable to consult your doctor.
  • Increased heart rate: Orphenadrine may elevate heart rate in some individuals. If you have any underlying heart conditions or experience significant changes in heart rate, it is important to seek medical attention.
  • Allergic reactions: While rare, allergic reactions to orphenadrine can occur. Signs of an allergic reaction include rash, itching, swelling, severe dizziness, or difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.

It is important to note that this list is not exhaustive, and other side effects may occur. It is always recommended to consult a healthcare professional for comprehensive information about the potential side effects and risks associated with specific medications.

What should I know about storage and disposal of this medication?


  • Store orphenadrine at room temperature, away from moisture, heat, and light.
  • Keep the medication out of reach of children and pets.
  • Store it in its original container or packaging, with the lid tightly closed.


  • Do not flush orphenadrine down the toilet or drain, as it may contaminate the water supply.
  • Check with your local pharmacy or waste disposal facility for guidelines on how to safely dispose of medication.
  • If no specific instructions are available, you can mix the medication with an undesirable substance, like cat litter or coffee grounds, and place it in a sealed bag before throwing it in the trash.

In case of emergency/overdose

  • In case of an emergency or suspected overdose, call your local emergency helpline immediately or go to the nearest emergency room.
  • Provide the healthcare professionals with as much information as possible, including the amount of orphenadrine taken, the time of ingestion, and any symptoms experienced.
  • If someone loses consciousness, has difficulty breathing, or has seizures, call emergency services right away.

What other information should I know?

  • Orphenadrine may cause drowsiness and impair your ability to drive or operate machinery. Avoid these activities until you know how the medication affects you.
  • Inform your doctor about any other medications you are taking, as well as any medical conditions you have, to avoid potential drug interactions or contraindications.
  • Do not exceed the prescribed dosage of orphenadrine. Taking more than the recommended amount can increase the risk of side effects and overdose.
  • If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
  • Follow the instructions provided by your healthcare provider regarding the duration of treatment with orphenadrine. Do not stop taking it abruptly without consulting your doctor.

Remember, this information is a general guideline. Always consult your healthcare provider or pharmacist for specific instructions and advice regarding the use, storage, and disposal of orphenadrine.

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