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Insulin Degludec (rDNA Origin) Injection

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Why is this medication prescribed?

Insulin Degludec (rDNA origin) injection is prescribed to manage blood sugar levels in individuals with diabetes. It is a long-acting insulin analog that is used to control both type 1 and type 2 diabetes.

Insulin is a hormone that helps regulate the amount of sugar (glucose) in the blood. In people with diabetes, their bodies either do not produce enough insulin (type 1 diabetes) or do not effectively use the insulin they produce (type 2 diabetes). Insufficient insulin levels or ineffective insulin action can result in high blood sugar levels, which, if left uncontrolled, can lead to various health complications.

Insulin Degludec works by replacing the natural insulin in the body, providing a steady level of insulin throughout the day and night. It has an extended duration of action, which allows for once-daily or less frequent dosing. This can help individuals with diabetes maintain stable blood sugar levels and reduce the risk of both short-term and long-term complications associated with diabetes.

How should this medicine be used?

The following information provides a general overview, but it may not cover all the necessary details for your specific situation.

Here are some general guidelines for using Insulin Degludec:

  • Administration: Insulin Degludec is typically injected subcutaneously (under the skin) using a syringe, pen injector, or an insulin pump. It should not be administered intravenously.
  • Dosage: The appropriate dosage will depend on various factors, including your blood sugar levels, individual insulin requirements, and the guidance of your healthcare provider. The dosage may need to be adjusted over time based on your response and blood sugar monitoring.
  • Timing: Insulin Degludec is a long-acting insulin that provides a continuous release of insulin over a 24-hour period. It is usually taken once daily at the same time each day. However, your healthcare provider may prescribe a different dosing schedule based on your specific needs.
  • Injection sites: The recommended injection sites for Insulin Degludec include the abdomen, thigh, or upper arm. It is important to rotate injection sites within the same general area to avoid developing lumps or changes in the fat tissue under the skin.
  • Preparation: If you are using a vial of Insulin Degludec, it should be gently rolled or tilted between your hands to mix the contents before drawing the dose. Do not shake the vial vigorously as it may cause foaming.
  • Injection technique: Follow the instructions provided by your healthcare professional for proper injection technique. It typically involves cleaning the injection site with an alcohol swab, pinching the skin, inserting the needle at the recommended angle, and injecting the medication slowly.
  • Monitoring: Regular monitoring of blood sugar levels is essential to assess the effectiveness of Insulin Degludec and make any necessary dosage adjustments. Your healthcare provider will guide you on the frequency of blood sugar testing and the target range for your specific condition.
  • Storage: Insulin Degludec should be stored in the refrigerator at a temperature between 36°F and 46°F (2°C to 8°C). It should not be frozen. If needed, the unopened vials or pens can be kept at room temperature (below 86°F or 30°C) for up to 56 days.

It’s important to consult with your healthcare provider or diabetes educator for detailed instructions on using Insulin Degludec, as they can provide personalized guidance and address any specific concerns or questions you may have. They will also provide information on potential side effects, precautions, and other important considerations related to your individual circumstances.

Other uses for this medicine

Insulin Degludec (rDNA Origin) Injection is a long-acting insulin analog used to control blood sugar levels in adults and children with diabetes mellitus. It is primarily used for the treatment of type 1 diabetes and type 2 diabetes. However, it is important to note that Insulin Degludec is primarily indicated for diabetes management and does not have approved uses for other medical conditions.

What special precautions should I follow?

As with any medication, there are certain precautions and considerations that need to be taken into account when using Insulin Degludec (rDNA Origin) Injection. Here are some important precautions:

  • Hypoglycemia (low blood sugar): Insulin Degludec can cause hypoglycemia, which is a potentially serious condition. It is important to closely monitor blood sugar levels and be aware of the signs and symptoms of hypoglycemia, such as dizziness, shakiness, sweating, confusion, and blurred vision. If hypoglycemia occurs, appropriate treatment should be administered, such as consuming glucose tablets, fruit juice, or candy.
  • Hyperglycemia (high blood sugar): Insulin Degludec is used to lower blood sugar levels, but it is possible for blood sugar levels to become too high (hyperglycemia) if the dosage is insufficient or other factors are involved. Regular monitoring of blood sugar levels is essential, and adjustments to the insulin dosage may be required under the guidance of a healthcare professional.
  • Allergic reactions: Some individuals may be allergic to Insulin Degludec or its components. Allergic reactions can manifest as skin rashes, itching, swelling, or difficulty breathing. If you experience any signs of an allergic reaction, seek immediate medical attention.
  • Hypokalemia (low potassium levels): Insulin Degludec may cause a decrease in potassium levels in the blood (hypokalemia). This can be a concern, especially for individuals with conditions predisposing them to low potassium or taking medications that can affect potassium levels. Regular monitoring of potassium levels is important in such cases.
  • Interactions with other medications: Insulin Degludec can interact with certain medications, including oral diabetes medications, other insulin products, beta-blockers, and certain blood pressure medications. It is important to inform your healthcare provider about all the medications, including over-the-counter drugs and supplements, that you are taking to avoid any potential interactions.
  • Pregnancy and breastfeeding: Insulin Degludec can be used during pregnancy and while breastfeeding. However, it is important to consult with a healthcare professional for appropriate dosage adjustments and monitoring.

It is crucial to follow the instructions provided by your healthcare provider regarding the use of Insulin Degludec (rDNA Origin) Injection and to report any concerns or side effects promptly. They will be able to provide personalized guidance based on your specific medical condition and needs.

What special dietary instructions should I follow?

There are no specific dietary restrictions for Insulin Degludec. However, it’s important to follow a balanced and healthy diet as recommended by your healthcare provider or dietitian. They may suggest managing your carbohydrate intake and timing your meals to match your insulin dosing.

What should I do if I forget a dose?

If you forget a dose of Insulin Degludec, the appropriate action depends on the specific instructions given to you by your healthcare provider. In general, you should:

  • Take the missed dose as soon as possible. Then, continue with your regular dosing schedule.
  • Skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for the missed one.

What side effects can this medication cause?

Like any medication, it can potentially cause side effects. Here are some possible side effects associated with Insulin Degludec:

  • Hypoglycemia: The most common side effect of insulin therapy is low blood sugar levels (hypoglycemia). Symptoms may include sweating, dizziness, confusion, shakiness, fast heartbeat, headache, and hunger. It’s important to monitor blood sugar levels closely and be aware of the signs and symptoms of hypoglycemia.
  • Injection site reactions: Insulin Degludec is administered via subcutaneous injection, and some individuals may experience injection site reactions, such as redness, swelling, itching, or pain at the injection site. These reactions are usually mild and resolve on their own.
  • Weight gain: Insulin therapy can sometimes lead to weight gain. This occurs due to improved glucose control, which allows the body to store energy more efficiently. It’s important to maintain a healthy diet and engage in regular physical activity to manage weight effectively.
  • Allergic reactions: In rare cases, some individuals may experience an allergic reaction to Insulin Degludec. Signs of an allergic reaction may include rash, itching, swelling, dizziness, and difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.
  • Fluid retention: Insulin therapy can cause fluid retention, leading to swelling in the hands, feet, or ankles. It’s important to monitor your fluid intake and report any persistent or worsening swelling to your healthcare provider.
  • Hypokalemia: Insulin can cause a decrease in blood potassium levels, leading to hypokalemia. This condition may cause symptoms like muscle weakness, cramps, irregular heartbeat, and fatigue. Your healthcare provider will monitor your potassium levels regularly and provide appropriate management if necessary.

It’s important to note that these are not the only possible side effects of Insulin Degludec. Different individuals may experience different reactions to the medication. It’s crucial to discuss any concerns or unusual symptoms with your healthcare provider, as they can provide personalized advice and guidance.

What should I know about storage and disposal of this medication?


  • Insulin Degludec should be stored in a refrigerator between 36°F to 46°F (2°C to 8°C).
  • Do not freeze Insulin Degludec. Freezing can damage the medication and make it ineffective.
  • If needed, Insulin Degludec can be stored at room temperature (between 59°F to 86°F or 15°C to 30°C) for up to 56 days. After this period, any unused portion should be discarded.


  • Dispose of used insulin syringes, needles, and cartridges in accordance with local regulations or guidelines.
  • Insulin Degludec should not be reused or shared with others. Each syringe or pen should be used by a single individual for safety and hygiene reasons.

In case of emergency/overdose

  • Hypoglycemia (Low Blood Sugar): If you experience symptoms of low blood sugar such as dizziness, confusion, sweating, or shaking, consume a fast-acting source of sugar like fruit juice, glucose tablets, or candy. Follow this with a snack or meal containing protein and carbohydrates. Inform your healthcare provider about the incident.
  • Hyperglycemia (High Blood Sugar): If you experience symptoms of high blood sugar such as frequent urination, excessive thirst, or fruity-smelling breath, contact your healthcare provider for guidance.
  • Severe Allergic Reaction: In the case of a severe allergic reaction (e.g., difficulty breathing, swelling of the face or throat), seek emergency medical assistance immediately.

What other information should I know?

  • It is important to regularly monitor your blood sugar levels as directed by your healthcare provider while using Insulin Degludec.
  • Only adjust your insulin dosage as instructed by your healthcare provider. Do not change the dose without consulting them first.
  • Follow the administration instructions provided with your specific insulin delivery device (syringes, pens, etc.).
  • Make sure to inform all healthcare providers, including dentists and surgeons, about your use of Insulin Degludec before any medical procedure or surgery.
  • Check the expiration date on the medication and do not use it if it has expired.

Remember, this information serves as a general guide. Always consult your healthcare provider or pharmacist for specific instructions and advice regarding the storage, disposal, and emergency actions related to your Insulin Degludec medication.

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