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Infumorph (Generic Morphine Injection)

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Infumorph, also known as intrathecal morphine, is a potent opioid medication that is delivered directly into the spinal fluid through a catheter. While it can be an effective treatment for severe pain, it also carries certain risks and potential complications. Here are some of the risks associated with taking Infumorph:

  • Respiratory depression: One of the most significant risks of Infumorph is the potential for respiratory depression, which can lead to breathing difficulties or even respiratory arrest. It is crucial to closely monitor patients receiving Infumorph for any signs of respiratory depression.
  • Sedation and drowsiness: Infumorph can cause sedation and drowsiness, which may impair cognitive and motor functions. Patients taking Infumorph should avoid activities such as driving or operating heavy machinery that require alertness.
  • Nausea and vomiting: Infumorph can cause gastrointestinal side effects, including nausea and vomiting. These symptoms can be distressing for patients and may require additional medications to manage.
  • Itching and skin reactions: Some individuals may experience itching or other skin reactions as a result of Infumorph treatment. These symptoms can be bothersome but can usually be managed with antihistamines.
  • Infection and catheter-related complications: Since Infumorph requires the insertion of a catheter into the spinal fluid, there is a risk of infection at the site of insertion. Additionally, catheter-related complications such as catheter displacement or blockage can occur, requiring medical intervention.
  • Opioid tolerance and dependence: Long-term use of Infumorph can lead to the development of tolerance, meaning higher doses are needed to achieve the same level of pain relief. Prolonged use can also result in physical dependence, where abrupt discontinuation of the medication can lead to withdrawal symptoms.
  • Drug interactions and contraindications: Infumorph can interact with other medications, particularly other central nervous system depressants, such as sedatives or benzodiazepines, leading to increased sedation and respiratory depression. It is essential to inform healthcare providers about all medications being taken to avoid potential interactions.

It’s important to note that this is just a brief overview of the risks associated with Infumorph, and individual circumstances can vary. It is crucial to consult with a healthcare professional who can provide a comprehensive evaluation of the risks and benefits based on your specific medical history and condition.

Why is this medication prescribed?

Infumorph is a brand name for a medication called intrathecal morphine sulfate. It is a type of opioid analgesic that is primarily prescribed for the management of severe pain that cannot be adequately controlled with other pain medications or therapies. Intrathecal administration refers to the delivery of the medication directly into the cerebrospinal fluid (CSF) through a catheter placed in the spinal canal.

Infumorph is used when other methods of pain relief, such as oral or intravenous medications, have not been effective or are associated with intolerable side effects. It is commonly employed in cases of chronic pain, cancer pain, and certain types of postoperative pain.

How should this medicine be used?

Infumorph, or intrathecal morphine sulfate, is typically administered through an implanted pump system that delivers the medication directly into the cerebrospinal fluid (CSF) in the spinal canal. The pump is surgically placed under the skin, usually in the abdominal area, and is connected to a catheter that delivers the medication to the intrathecal space.

The dosing and administration of Infumorph are highly individualized and depend on various factors, including the severity of pain, patient response, and tolerability. The pump is programmed to deliver a specific amount of medication over a predetermined period, and the dosage may be adjusted over time to optimize pain control while minimizing side effects.

It’s crucial to follow the prescribed dosing instructions and any specific guidelines provided by the healthcare professional overseeing the treatment. Regular follow-up appointments and ongoing monitoring are necessary to ensure the medication is effective and to address any potential complications or side effects associated with its use.

It is important to note that the administration of Infumorph and the management of the pump system require specialized medical expertise. Therefore, it should only be used under the guidance of a qualified healthcare professional who has experience in intrathecal therapy and can provide proper monitoring and support throughout the treatment.

Other uses for this medicine

While its primary use is for pain relief, there are a few other specific indications for Infumorph:

  • Postoperative pain control: Infumorph may be used in patients who have undergone major surgeries, particularly those involving the abdomen, pelvis, or lower extremities, where traditional pain management methods may not provide adequate relief.
  • Chronic pain management: In some cases, when other pain medications and interventions have not been effective, Infumorph may be used for long-term pain management in chronic conditions like cancer-related pain, neuropathic pain, or severe back pain.

What special precautions should I follow?

As for special precautions when using Infumorph, it is crucial to consider the following:

  • Expert administration: Infumorph should only be administered by trained healthcare professionals who are experienced in the technique of intrathecal drug delivery. This is necessary to ensure accurate dosage and minimize the risk of complications.
  • Sterility: Strict aseptic technique is essential during the preparation and administration of Infumorph to minimize the risk of infection.
  • Titration and monitoring: Infumorph dosages need to be carefully titrated to find the optimal amount that provides pain relief without causing excessive side effects. Patients receiving Infumorph should be closely monitored for respiratory depression, sedation, and other opioid-related adverse effects.
  • Respiratory depression: Infumorph is a potent opioid, and one of the most significant risks associated with its use is respiratory depression. It should be used with caution in patients with compromised respiratory function, such as those with severe chronic obstructive pulmonary disease (COPD) or sleep apnea.
  • Potential side effects and interactions: Infumorph can cause various side effects, including nausea, vomiting, constipation, dizziness, sedation, and itching. It can also interact with other medications, particularly other opioids, sedatives, or benzodiazepines, leading to increased central nervous system depression.

It’s important to note that specific precautions and recommendations may vary depending on the patient’s individual condition and the prescribing healthcare professional’s judgment. Therefore, it is essential to consult with a healthcare provider for personalized advice and guidance regarding the use of Infumorph.

What special dietary instructions should I follow?

It’s essential to follow your healthcare provider’s instructions regarding any dietary restrictions or modifications specific to your overall treatment plan. They may recommend certain dietary changes or restrictions based on your individual needs, overall health, and other medications you might be taking.

What should I do if I forget a dose?

Regarding a missed dose, it’s crucial to consult your healthcare provider for specific guidance. They will be able to advise you on the best course of action. Missing a dose of Infumorph may result in a return of pain symptoms, so it’s important to address any missed doses promptly. It’s generally not recommended to double up on doses to make up for a missed one without medical guidance.

What side effects can this medication cause?

Infumorph, also known as intrathecal morphine, is a medication used to manage severe and chronic pain by delivering morphine directly into the spinal fluid through a catheter. While infumorph can be effective in providing pain relief, it may also have some side effects. Common side effects of infumorph can include:

  • Nausea and vomiting: These are relatively common side effects of opioid medications, including morphine.
  • Constipation: Opioids can slow down bowel movements, leading to constipation. Adequate fluid intake and the use of stool softeners or laxatives may be necessary.
  • Itching or rash: Some individuals may experience itching or develop a rash as a result of infumorph treatment.
  • Respiratory depression: Infumorph, like other opioids, can suppress breathing in high doses or in individuals who are sensitive to the medication. This effect is more common when higher doses are used.
  • Sedation or drowsiness: Infumorph can cause drowsiness or sedation, which may impair cognitive and physical abilities. It is important to exercise caution when performing activities that require alertness, such as driving or operating heavy machinery.
  • Urinary retention: Infumorph can affect bladder function, leading to difficulty in urination or urinary retention.
  • Hypotension: Infumorph may cause a drop in blood pressure, resulting in dizziness or lightheadedness.
  • Allergic reactions: While rare, some individuals may experience allergic reactions to infumorph, which can manifest as swelling, hives, or difficulty breathing.

It is essential to note that not everyone will experience these side effects, and the severity and occurrence can vary from person to person. Additionally, other less common or more severe side effects may occur. It is crucial to consult with a healthcare professional who can provide personalized information and guidance based on an individual’s specific situation.

What should I know about storage and disposal of this medication?


  • Keep Infumorph in its original container and tightly closed to protect it from light and moisture.
  • Store it at room temperature (between 68°F and 77°F or 20°C and 25°C), away from heat sources.
  • Ensure that it is kept out of reach of children and pets.
  • Follow any specific storage instructions provided by your healthcare provider or pharmacist.


  • Dispose of unused or expired Infumorph properly to prevent misuse or accidental ingestion.
  • Follow local regulations and guidelines for medication disposal. Do not flush it down the toilet or pour it into drains, unless instructed otherwise.
  • If you are unsure about the appropriate disposal method, consult your pharmacist or healthcare provider for guidance.

In case of emergency/overdose

  • If someone has taken too much Infumorph or is experiencing an overdose, call emergency services immediately (e.g., 911 in the United States).
  • Stay with the person until help arrives and provide them with comfort and reassurance.
  • Do not induce vomiting unless instructed by a healthcare professional.
  • Be prepared to provide information about the individual’s age, weight, the amount of medication taken, and the time it was ingested.

What other information should I know?

  • Only use Infumorph as prescribed by your healthcare provider. Do not change the dosage or frequency without consulting them.
  • Inform your healthcare provider about any other medications or substances you are taking, as they may interact with Infumorph and cause adverse effects.
  • It’s important to be aware of the potential side effects of Infumorph, such as drowsiness, constipation, nausea, vomiting, or respiratory depression. Contact your healthcare provider if you experience severe or persistent side effects.
  • Infumorph is a controlled substance, and its use should be closely monitored to prevent misuse, addiction, or dependence.
  • Follow your healthcare provider’s instructions regarding the proper administration of Infumorph, such as dosage, duration, and method of use (e.g., intravenous, intrathecal).
  • Inform your healthcare provider if you have a history of substance abuse, respiratory disorders, kidney or liver problems, or any other medical conditions.

It’s crucial to consult your healthcare provider or pharmacist for detailed and personalized instructions on the storage, disposal, and handling of Infumorph, as they can provide the most accurate and up-to-date information based on your specific situation.

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