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Increlex (Generic Mecasermin Injection)

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Why is this medication prescribed?

Increlex (mecasermin) is prescribed for the treatment of growth failure in children with severe primary insulin-like growth factor-1 (IGF-1) deficiency or with growth hormone (GH) gene deletion who have developed neutralizing antibodies to GH.

IGF-1 is a hormone that is important for growth and development, particularly during childhood and adolescence. It works in conjunction with growth hormone (GH) to promote bone and tissue growth. In some cases, children may have a deficiency in IGF-1 or may develop antibodies that neutralize the effects of GH, leading to growth failure.

Increlex is a synthetic form of IGF-1 that acts as a replacement therapy for children with IGF-1 deficiency or GH gene deletion. By administering Increlex, the levels of IGF-1 in the body are increased, which can stimulate bone and tissue growth, ultimately helping these children to achieve a more normal height and catch up with their growth.

How should this medicine be used?

Increlex (mecasermin) is administered through subcutaneous (under the skin) injections. The dosage and frequency of injections will be determined by the child’s healthcare provider based on their individual needs.

Here are some general guidelines for using Increlex:

  • Administration: Increlex should be injected subcutaneously, which means it is injected into the fatty tissue just below the skin. The injection sites should be rotated to avoid lipodystrophy (a condition where fatty tissue beneath the skin becomes lumpy or atrophied). Common injection sites include the thigh, upper arm, or abdomen.
  • Preparation: Increlex is supplied as a powder that needs to be reconstituted with the accompanying sterile water for injection. The healthcare provider will provide instructions on how to properly mix the medication. The reconstituted solution should be clear and colorless. Do not use the solution if it appears cloudy or discolored.
  • Dosage: The specific dosage of Increlex will be determined by the healthcare provider based on the child’s weight, age, and individual response to the treatment. It’s important to follow the prescribed dosage carefully and not to adjust the dosage without consulting the healthcare provider.
  • Frequency: Increlex is typically administered once or twice daily. The healthcare provider will provide guidance on the appropriate frequency of injections based on the child’s needs. It’s important to adhere to the prescribed schedule and not miss any doses.
  • Injection technique: The healthcare provider will provide detailed instructions on the proper injection technique. It’s important to follow these instructions carefully to ensure accurate and safe administration. If necessary, a healthcare professional can demonstrate the injection technique and address any concerns or questions.

It’s important to attend regular follow-up appointments with the healthcare provider to monitor the child’s growth progress and response to the treatment. The healthcare provider may adjust the dosage or frequency of Increlex based on the child’s growth and IGF-1 levels.

Remember, the above information provides a general overview of how Increlex is used. The specific instructions and guidance for using Increlex should be provided by the prescribing healthcare professional, and it’s important to follow their instructions closely.

Other uses for this medicine

Besides its primary use for growth failure related to IGF-1 deficiency, Increlex may be used off-label for other conditions. Some potential off-label uses include:

  • Short stature associated with Turner syndrome
  • Insulin resistance syndromes
  • Muscle wasting disorders

What special precautions should I follow?

When it comes to precautions, it’s crucial to follow the guidance provided by your healthcare provider. Some general precautions associated with Increlex include:

  • Hypoglycemia: Increlex can lower blood sugar levels, leading to hypoglycemia. Close monitoring of blood glucose levels is essential during treatment, especially in individuals with diabetes or insulin resistance.
  • Tumors and Cancer Risk: Increlex should not be used in individuals with active or recurring tumors, as it may promote tumor growth. Regular monitoring for tumor development is necessary during treatment.
  • Allergic Reactions: Some individuals may experience allergic reactions to Increlex. Seek immediate medical attention if you develop symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
  • Intracranial Hypertension: Increlex can cause an increase in intracranial pressure, which may lead to headaches, visual disturbances, or other symptoms. It is important to report any such symptoms to your healthcare provider.
  • Pregnancy and Breastfeeding: The safety of Increlex during pregnancy and breastfeeding has not been established. Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Remember, these precautions are not exhaustive, and it’s essential to consult with a healthcare professional to understand the specific precautions and potential risks associated with Increlex in your individual case.

What special dietary instructions should I follow?

When taking Increlex (mecasermin), it’s important to follow special dietary instructions to ensure optimal absorption and effectiveness of the medication. Here are some dietary guidelines to consider:

  • Take Increlex with a meal or snack: It is recommended to take Increlex within 20 minutes before or after a meal or snack. This helps to minimize fluctuations in blood sugar levels and improves absorption.
  • Include carbohydrates in meals or snacks: Including carbohydrates in your meals or snacks helps to prevent low blood sugar (hypoglycemia) that can occur as a side effect of Increlex. Carbohydrates provide a source of energy and help balance blood sugar levels.
  • Avoid foods high in fat: High-fat meals can slow down the absorption of Increlex. It is advisable to avoid consuming large amounts of fatty foods around the time of taking the medication.
  • Limit simple sugars: While carbohydrates are important, it is advisable to avoid excessive consumption of simple sugars, such as sugary drinks and candies, as they can cause rapid fluctuations in blood sugar levels.

What should I do if I forget a dose?

If you forget to take a dose of Increlex, here’s what you should do:

  • Take the missed dose as soon as you remember: If you realize you missed a dose, take it as soon as you remember. However, if it’s already close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
  • Contact your healthcare provider: It is important to inform your healthcare provider about the missed dose. They can provide further guidance and may make adjustments to your dosing schedule if necessary.

What side effects can this medication cause?

Increlex (mecasermin) is a medication used to treat growth failure in children who have a deficiency of insulin-like growth factor 1 (IGF-1). While Increlex can be effective in promoting growth, it may also cause certain side effects. It’s important to note that individual experiences with medication can vary, and not all people will experience these side effects. Common side effects of Increlex may include:

  • Hypoglycemia: Since Increlex affects insulin signaling, it can lower blood sugar levels, leading to symptoms such as dizziness, shakiness, sweating, and confusion.
  • Injection site reactions: Redness, itching, pain, or swelling at the injection site are common side effects of Increlex. These reactions are usually mild and temporary.
  • Lipohypertrophy: With prolonged use of injections in the same area, fatty lumps or thickened skin may develop at the injection sites. Rotating the injection sites can help minimize this effect.
  • Headache: Some individuals may experience headaches while taking Increlex. These headaches are generally mild and resolve on their own.
  • Increased intracranial pressure: Rarely, Increlex can cause an increase in pressure inside the skull, leading to symptoms such as persistent headache, visual disturbances, and nausea. If these symptoms occur, medical attention should be sought immediately.
  • Ear and sinus infections: Increlex may increase the risk of ear and sinus infections, particularly in individuals with a history of these conditions.
  • Respiratory infections: Some individuals may be more prone to developing respiratory infections while taking Increlex.

It’s important to discuss any concerns or potential side effects with a healthcare provider. They can provide personalized advice and guidance based on the individual’s specific circumstances.

What should I know about storage and disposal of this medication?


  • Store Increlex in the refrigerator at a temperature between 36°F and 46°F (2°C and 8°C).
  • Do not freeze the medication.
  • Keep Increlex in its original packaging to protect it from light.


  • Do not dispose of Increlex in household trash or flush it down the toilet unless specifically instructed to do so.
  • Contact your healthcare provider or pharmacist to learn about safe medication disposal methods in your area.
  • Follow any local regulations or guidelines for the disposal of pharmaceutical waste.

In case of emergency/overdose

  • In case of an emergency or overdose, immediately call your local emergency number (e.g., 911) or seek medical assistance.
  • It is essential to provide healthcare professionals with detailed information about the medication, dosage, and the situation.
  • If possible, bring the medication packaging or bottle with you to the healthcare facility.

What other information should I know?

  • Always use Increlex as prescribed by your healthcare provider. Do not change the dosage or stop taking it without consulting your doctor.
  • Inform your healthcare provider about any medical conditions you have, especially if you have a history of diabetes, cancer, or allergies.
  • Inform your healthcare provider about all the medications, supplements, or herbal products you are taking, as they may interact with Increlex.
  • Attend regular follow-up appointments with your doctor to monitor your progress and discuss any concerns or side effects you may be experiencing.

Remember, this information is a general guide, and it’s crucial to consult your healthcare provider or pharmacist for specific instructions regarding the storage, disposal, and emergency procedures related to Increlex. They can provide personalized advice based on your individual needs and circumstances.

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