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Imitrex Nasal Spray (Generic Sumatriptan Nasal)

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Why is this medication prescribed?

Imitrex Nasal Spray is prescribed for the treatment of acute migraine headaches in adults. Migraine is a neurological condition characterized by severe headaches often accompanied by other symptoms such as nausea, vomiting, and sensitivity to light and sound.

Imitrex Nasal Spray contains the active ingredient sumatriptan, which belongs to a class of medications called triptans. Triptans work by narrowing the blood vessels in the brain, reducing inflammation, and relieving the pain associated with migraines.

The nasal spray form of Imitrex offers a convenient and rapid method of delivery, allowing the medication to be absorbed quickly through the nasal passages and providing faster relief compared to oral medications. It is particularly useful for individuals who experience nausea or vomiting during migraines, as it bypasses the digestive system.

How should this medicine be used?

Imitrex Nasal Spray is prescribed for the treatment of acute migraine headaches in adults. It is used to relieve the symptoms of a migraine attack, including headache pain, nausea, and sensitivity to light and sound.

The specific instructions for using Imitrex Nasal Spray may vary depending on your healthcare provider’s recommendation. However, the general guidelines for using the medication are as follows:

  • Prepare the nasal spray: Remove the protective cap from the nasal spray bottle and check the expiration date. Before the first use or if the nasal spray hasn’t been used for a while, prime the pump by pumping it a few times until a fine mist is produced.
  • Administer the medication: Gently blow your nose to clear your nasal passages. Hold the nasal spray bottle upright and insert the tip into one nostril, aiming slightly away from the center of your nose. Close the other nostril with your finger. Breathe in gently through your nose while pressing down firmly on the pump to release the medication. Remove the nasal spray bottle from your nostril and breathe out through your mouth.
  • Repeat for the other nostril: If your healthcare provider has recommended using two sprays for each dose, repeat the same process for the other nostril.
  • Use as directed: The recommended dose of Imitrex Nasal Spray is usually one spray (5 mg or 20 mg) per nostril. However, your healthcare provider may prescribe a different dosage based on your specific needs. It’s important to follow their instructions carefully.
  • Additional doses: If your migraine symptoms return or if you have a partial response to the initial dose, a second dose may be taken after two hours. However, the maximum recommended dose within a 24-hour period should not exceed 40 mg.
  • Contact your healthcare provider: If your migraine symptoms do not improve or worsen after taking Imitrex Nasal Spray, or if you experience any concerning side effects, it is important to contact your healthcare provider for further guidance.

It’s worth noting that the above instructions are general guidelines and may not apply to everyone. Always follow the specific instructions provided by your healthcare provider and carefully read the medication’s packaging insert. If you have any questions or concerns about the proper use of Imitrex Nasal Spray, consult with your healthcare professional.

Other uses for this medicine

While Imitrex Nasal Spray is primarily prescribed for migraines, it is important to note that it should only be used for this specific purpose and as directed by a healthcare professional. It is not recommended for other types of headaches or conditions unless specifically prescribed by a doctor.

What special precautions should I follow?

Special precautions should be taken when using Imitrex Nasal Spray, and it is essential to consult with a healthcare professional for specific guidance. However, some general precautions include:

  • Allergies: Inform your doctor if you are allergic to sumatriptan or any other medications. Allergic reactions to Imitrex Nasal Spray can be serious and may include symptoms such as difficulty breathing, swelling, or rash.
  • Medical conditions: Inform your doctor about any medical conditions you have, especially if you have a history of heart problems, high blood pressure, liver disease, kidney disease, or any other significant health conditions.
  • Medication interactions: Inform your doctor about all the medications you are currently taking, including prescription, over-the-counter, and herbal products. Some medications, such as certain antidepressants or migraine medications, can interact with Imitrex Nasal Spray and cause potentially harmful effects.
  • Cardiovascular effects: Imitrex Nasal Spray can cause narrowing of blood vessels, which may result in increased blood pressure or other cardiovascular effects. It is important to discuss your cardiovascular health with your doctor before using this medication, especially if you have a history of heart disease, angina, stroke, or other cardiovascular conditions.
  • Serotonin syndrome: Imitrex Nasal Spray affects serotonin levels in the body. Serotonin syndrome is a rare but serious condition that can occur when there is an excess of serotonin in the body. Symptoms may include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and coordination problems. If you experience any of these symptoms, seek medical attention immediately.

Remember, this information provides a general overview of precautions for Imitrex Nasal Spray, and it is crucial to consult with your doctor or healthcare professional for personalized advice based on your specific medical history and circumstances.

What special dietary instructions should I follow?

When it comes to special dietary instructions for Imitrex Nasal Spray, there are no specific dietary restrictions associated with this medication.

What should I do if I forget a dose?

If you forget to take a dose of Imitrex Nasal Spray, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

What side effects can this medication cause?

Imitrex Nasal Spray, which contains the active ingredient sumatriptan, can cause several side effects. Not everyone who uses this medication will experience these side effects, but it’s important to be aware of them. Common side effects of Imitrex Nasal Spray may include:

  • Pain or sensation of pressure or tightness in the chest or throat
  • Tingling or warmth/flushing sensations
  • Dizziness or lightheadedness
  • Nausea or vomiting
  • Fatigue or drowsiness
  • Dry mouth
  • Nasal discomfort or irritation

These side effects are usually temporary and mild, and they tend to improve on their own without medical intervention. However, if they persist or worsen, it’s recommended to consult your healthcare provider.

In rare cases, Imitrex Nasal Spray can cause more serious side effects. If you experience any of the following, it’s important to seek immediate medical attention:

  • Severe chest pain, tightness, or pressure (which may be an indication of a heart-related issue)
  • Signs of a serious allergic reaction, such as hives, itching, rash, swelling, severe dizziness, or difficulty breathing
  • Severe or persistent headache or migraines that are not relieved by the medication
  • Sudden numbness or weakness, especially on one side of the body
  • Severe stomach pain or bloody diarrhea
  • Vision changes or eye pain

These are not all the possible side effects of Imitrex Nasal Spray. If you experience any other unusual symptoms or have concerns about the medication, it’s important to consult your healthcare provider or pharmacist for further evaluation and guidance.

What should I know about storage and disposal of this medication?


  • Store Imitrex Nasal Spray at room temperature, between 68°F and 77°F (20°C and 25°C).
  • Keep it away from direct sunlight and heat.
  • Do not freeze the medication.


  • Follow your local regulations or guidelines for the disposal of medications.
  • If you are unsure about the proper disposal method, consult your pharmacist or healthcare provider.
  • Do not flush the medication down the toilet or pour it down the drain unless instructed to do so.

In case of emergency/overdose

  • If you suspect an overdose or experience severe symptoms after using Imitrex Nasal Spray, seek immediate medical attention or call emergency services.
  • Symptoms of an overdose may include changes in heart rate, severe dizziness, fainting, seizures, or difficulty breathing.
  • It’s important to inform healthcare professionals about the medication you have taken and the dosage.

What other information should I know?

  • Imitrex Nasal Spray is used to treat migraines but is not intended for the prevention of migraines.
  • It should be used as soon as possible after the onset of a migraine attack.
  • Follow the dosage instructions provided by your doctor or pharmacist carefully.
  • Do not exceed the recommended dose or use the medication more frequently than prescribed.
  • Inform your doctor about any other medical conditions you have and any other medications you are taking, as they may interact with Imitrex Nasal Spray.
  • Common side effects may include mild nasal irritation, bad taste, or a feeling of pressure or tightness in the throat or chest. However, if these side effects worsen or persist, contact your doctor.
  • It’s important to keep Imitrex Nasal Spray out of the reach of children and pets.
  • If the medication changes color, becomes cloudy, or shows any signs of deterioration, do not use it and consult your pharmacist.

Remember, this information is not exhaustive, and it’s always advisable to consult your healthcare provider or pharmacist for specific instructions and any additional information about the storage, disposal, and use of Imitrex Nasal Spray.

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