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Imitrex Injection (Generic Sumatriptan Injection)

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Why is this medication prescribed?

Imitrex Injection, also known as sumatriptan injection, is a medication prescribed for the treatment of acute migraine attacks with or without aura in adults. Migraine headaches are often characterized by severe head pain, sensitivity to light and sound, and nausea. Sumatriptan belongs to a class of medications called triptans, which work by narrowing blood vessels in the brain and reducing inflammation. This helps to relieve the symptoms of a migraine attack. Imitrex Injection is typically used when a fast-acting migraine relief is required or when other forms of medication, such as oral tablets or nasal sprays, have not provided sufficient relief. The injection delivers the medication directly into the bloodstream, allowing for faster and more effective relief.

How should this medicine be used?

Imitrex Injection, or sumatriptan injection, should be used as directed by your healthcare provider. Here are general guidelines for the use of Imitrex Injection:

  • Preparation: Before using the injection, make sure to read the instructions provided with the medication and follow them carefully. The injection is usually packaged as a single-dose prefilled syringe or an autoinjector device.
  • Administration: Clean the injection site with an alcohol swab and let it dry. The typical injection site is the fatty tissue just under the skin of your thigh, upper arm, or stomach area. Remove the needle cap and hold the syringe or autoinjector at a 90-degree angle to the skin. Firmly press the syringe or autoinjector against the skin to activate the injection. The medication will be delivered subcutaneously (under the skin).
  • Dose: The appropriate dose of Imitrex Injection should be determined by your healthcare provider. The usual recommended dose is 4 mg or 6 mg per injection. A second dose may be administered after a minimum of 1 hour if needed. The maximum recommended dose within a 24-hour period is 12 mg.
  • Timing: Imitrex Injection is most effective when used as soon as possible after the onset of a migraine attack. It can be used at any time during a migraine attack but may be less effective if used during the aura phase (if you experience auras before your migraines).
  • Additional injections: If your migraine symptoms return after an initial injection, you may take a second dose after a minimum of 1 hour. However, the total dose within a 24-hour period should not exceed the maximum recommended dose of 12 mg.
  • Post-injection care: After the injection, dispose of the used syringe or autoinjector as instructed by your healthcare provider or the product label. You should not reuse or share injection devices.

It is important to remember that the above instructions are general guidelines. Always consult your healthcare provider for specific instructions on how to use Imitrex Injection or if you have any questions or concerns about its administration.

Other uses for this medicine

While Imitrex Injection is mainly prescribed for migraines, there may be instances where healthcare professionals prescribe it for off-label uses. Some examples of off-label uses of Imitrex Injection may include cluster headaches, severe headaches associated with other conditions, and certain types of vascular headaches. However, the decision to use Imitrex for these conditions would be made by a healthcare provider based on individual circumstances.

What special precautions should I follow?

As for special precautions associated with Imitrex Injection, here are a few important points to consider:

  • Allergies: If you have a known allergy to sumatriptan or any of the components in Imitrex Injection, you should avoid using it.
  • Cardiovascular conditions: Imitrex can cause narrowing of blood vessels, including those in the heart. Therefore, it is generally not recommended for individuals with a history of heart problems, including heart attacks, angina (chest pain), or ischemic heart disease.
  • Uncontrolled hypertension: Imitrex may increase blood pressure, so it should be used with caution in individuals with uncontrolled high blood pressure.
  • Stroke or transient ischemic attack (TIA): As with heart conditions, Imitrex may increase the risk of cerebrovascular events, so caution is advised in individuals with a history of stroke or TIA.
  • Other medical conditions: It’s important to inform your healthcare provider about any other medical conditions you have, such as liver or kidney disease, as these may affect the use of Imitrex Injection.
  • Drug interactions: Imitrex may interact with certain medications, including other migraine medications, ergotamine derivatives, selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAOIs). Inform your healthcare provider about all the medications you are taking to avoid potential interactions.

These are just a few general precautions associated with Imitrex Injection. Always follow your healthcare provider’s instructions and read the medication guide provided with the product for detailed information on precautions, side effects, and proper use.

What special dietary instructions should I follow?

Imitrex (sumatriptan) is a medication used for the treatment of migraines and cluster headaches. As an injection, it bypasses the digestive system, so there are no specific dietary instructions to follow regarding food or beverages. However, it is important to follow the dosing instructions provided by your healthcare provider. Typically, the injection should be administered as soon as possible after the onset of a migraine or cluster headache.

What should I do if I forget a dose?

If you forget to take a dose of Imitrex, it’s best to take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It’s important not to double the dose to make up for a missed one. If you have any concerns or questions about your dosing schedule, it’s recommended to consult your healthcare provider for further guidance.

What side effects can this medication cause?

Imitrex (sumatriptan) Injection, like any medication, can potentially cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience different reactions. If you have specific concerns about the side effects of Imitrex Injection, it is recommended to consult with your healthcare provider or pharmacist for personalized information. Here are some common side effects associated with Imitrex Injection:

  • Injection site reactions: This can include pain, redness, swelling, or itching at the injection site.
  • Tingling or numbness: Some people may experience a sensation of tingling or numbness, typically transient, which can affect the face, hands, or feet.
  • Flushing or warmth: This may cause a feeling of warmth or flushing, often in the chest or neck area.
  • Dizziness or drowsiness: Imitrex can cause dizziness or drowsiness in some individuals, so caution should be exercised when performing activities that require alertness, such as driving or operating machinery.
  • Nausea and vomiting: These gastrointestinal symptoms may occur after using Imitrex Injection.
  • Sensations of tightness, pressure, or heaviness: Some individuals may experience sensations of tightness, pressure, or heaviness in various parts of the body, including the chest, throat, neck, or limbs.
  • Unusual sensations: Imitrex may cause unusual sensations, such as feelings of heaviness or tightness in the throat, jaw, or neck.
  • Weakness or fatigue: Some people may experience weakness or fatigue after using Imitrex Injection.
  • Palpitations or increased heart rate: Imitrex can affect the cardiovascular system, and some individuals may experience an increased heart rate or palpitations.
  • Blood pressure changes: Imitrex may cause increases or decreases in blood pressure in some individuals.

It’s important to seek medical attention if you experience severe or persistent side effects, as well as any signs of an allergic reaction (e.g., rash, itching, swelling, severe dizziness, difficulty breathing). Your healthcare provider will be able to provide you with more detailed information about the potential side effects and help assess whether the benefits of using Imitrex outweigh the risks for your specific situation.

What should I know about storage and disposal of this medication?


  • Store Imitrex Injection at room temperature between 68°F and 77°F (20°C and 25°C).
  • Keep it away from direct sunlight and heat sources.
  • Do not freeze the medication.
  • Store the injection kit in the original packaging until ready to use.
  • Keep Imitrex Injection out of the reach of children and pets.


  • Follow any specific disposal instructions provided by your healthcare provider or pharmacist.
  • If no specific instructions are given, dispose of the unused or expired medication by following your local regulations.
  • Do not flush Imitrex Injection down the toilet or pour it into drains unless instructed to do so.

In case of emergency/overdose

  • In case of an emergency, such as a severe allergic reaction (e.g., difficulty breathing, hives, swelling), call emergency services immediately (911 in the United States) or go to the nearest emergency room.
  • If you suspect an overdose or have taken more Imitrex than prescribed, contact your local poison control center or seek immediate medical attention.
  • Symptoms of an overdose may include severe headache, dizziness, fainting, changes in mental status, increased heart rate, high blood pressure, and chest pain.

What other information should I know?

  • Imitrex Injection is meant for immediate relief of a migraine attack and should not be used for prophylaxis or to treat other types of headaches.
  • Follow the instructions provided by your healthcare provider on how to use the injection correctly.
  • Do not use Imitrex Injection if you have certain medical conditions such as heart problems, uncontrolled high blood pressure, peripheral vascular disease, or a history of stroke or transient ischemic attacks.
  • Inform your doctor about any other medications you are taking, including over-the-counter drugs and herbal supplements, as they may interact with Imitrex.
  • Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Imitrex during pregnancy or breastfeeding has not been established.

Remember to always consult your healthcare provider or pharmacist for specific instructions and guidance regarding the storage, disposal, and emergency procedures related to Imitrex Injection.

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