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Imipenem, Cilastatin, and Relebactam Injection

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Why is this medication prescribed?

Imipenem, cilastatin, and relebactam injection is a medication prescribed for the treatment of complicated urinary tract infections (including pyelonephritis, which is a kidney infection) and complicated intra-abdominal infections.

Imipenem is a broad-spectrum antibiotic that belongs to the carbapenem class. It works by inhibiting the growth of bacteria, including those that are resistant to other antibiotics. Imipenem is effective against a wide range of bacteria, including both Gram-positive and Gram-negative organisms.

Cilastatin is added to imipenem to prevent its breakdown by an enzyme called dehydropeptidase in the kidneys. By inhibiting this enzyme, cilastatin helps to increase the levels of imipenem in the body, enhancing its effectiveness.

Relebactam is a beta-lactamase inhibitor that is combined with imipenem and cilastatin to further enhance the spectrum of activity against certain types of bacteria. Beta-lactamase inhibitors work by inhibiting enzymes produced by bacteria that can destroy or inactivate certain antibiotics, such as imipenem. Relebactam helps to restore the effectiveness of imipenem against beta-lactamase-producing bacteria.

Together, imipenem, cilastatin, and relebactam provide a potent combination therapy against a broad range of bacteria, including those that are multidrug-resistant. It is usually prescribed when other antibiotics may not be effective or when the infection is known or suspected to involve bacteria that produce beta-lactamase enzymes. As with any antibiotic, it is important to use imipenem, cilastatin, and relebactam injection only as prescribed by a healthcare professional and to complete the full course of treatment to ensure the best possible outcome.

How should this medicine be used?

Imipenem, cilastatin, and relebactam injection is administered as an intravenous (IV) infusion, which means it is given directly into a vein. The dosage and administration of this medication should be determined by a healthcare professional, such as a doctor or nurse, based on the specific condition being treated and the patient’s individual factors.

Here are some general guidelines for the use of imipenem, cilastatin, and relebactam injection:

  • Administration: It is typically given as a 30-minute infusion into a vein. The injection is usually prepared by a healthcare professional in a healthcare setting such as a hospital.
  • Dosage: The dosage of imipenem, cilastatin, and relebactam is based on factors such as the severity of the infection, the patient’s weight, and kidney function. The healthcare professional will determine the appropriate dosage for each individual.
  • Duration of treatment: The duration of treatment with this medication will depend on the specific infection being treated. It is important to complete the full course of treatment as prescribed, even if symptoms improve before the medication is finished.
  • Follow healthcare professional’s instructions: It is crucial to follow the instructions provided by the healthcare professional regarding the administration of the medication, including the dosage, frequency, and duration of treatment.
  • Hospital setting: Imipenem, cilastatin, and relebactam injection is usually administered in a hospital or healthcare facility under the supervision of healthcare professionals. They will monitor the patient’s response to the medication and ensure its safe and effective use.

It is important to note that these are general guidelines, and the specific instructions for using imipenem, cilastatin, and relebactam injection may vary depending on the individual circumstances. It is always recommended to consult a healthcare professional for accurate and personalized information regarding the use of this medication.

Other uses for this medicine

Here are some other uses associated with this medication:

  • Imipenem, cilastatin, and relebactam injection is primarily used to treat complicated urinary tract infections, including pyelonephritis (kidney infection), caused by susceptible bacteria.
  • It may also be used for the treatment of complicated intra-abdominal infections, including appendicitis and peritonitis, caused by certain bacteria.

What special precautions should I follow?

Special Precautions:

  • Allergies: If you are allergic to any of the ingredients in imipenem, cilastatin, and relebactam injection or to other beta-lactam antibiotics (such as penicillins or cephalosporins), you should not take this medication. Inform your healthcare provider about any known allergies or sensitivities.
  • Seizure Disorders: Imipenem, cilastatin, and relebactam injection may lower the seizure threshold, potentially increasing the risk of seizures. If you have a history of seizure disorders or epilepsy, caution is advised, and your healthcare provider should monitor you closely during treatment.
  • Renal Impairment: This medication is primarily eliminated from the body through the kidneys. If you have impaired kidney function or are on dialysis, the dosage may need to be adjusted accordingly. Your healthcare provider will determine the appropriate dose for you based on your renal function.
  • Clostridioides difficile Infection: The use of antibiotics, including imipenem, cilastatin, and relebactam injection, can lead to an overgrowth of Clostridioides difficile bacteria in the colon, causing severe diarrhea and colitis. If you experience persistent diarrhea during or after treatment, inform your healthcare provider.
  • Drug Interactions: Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some drugs may interact with imipenem, cilastatin, and relebactam injection, potentially affecting its efficacy or increasing the risk of side effects.

It’s important to note that these are general precautions, and specific instructions and warnings may vary based on individual circumstances. Always follow the advice and instructions provided by your healthcare provider and read the medication guide or package insert for detailed information about the medication.

What special dietary instructions should I follow?

For Imipenem, Cilastatin, and Relebactam Injection, there aren’t any specific dietary restrictions mentioned in the prescribing information. However, it’s always a good idea to follow a healthy and balanced diet to support your overall well-being.

What should I do if I forget a dose?

Regarding missed doses, it’s crucial to take your medication as prescribed to ensure the effectiveness of the treatment. If you happen to forget a dose, contact your healthcare provider or pharmacist for guidance. They can advise you on the best course of action based on your specific situation. They may recommend taking the missed dose as soon as you remember or adjusting your dosing schedule. It’s important not to double up on doses unless instructed to do so.

What side effects can this medication cause?

Imipenem, Cilastatin, and Relebactam Injection are antibiotics used to treat certain types of infections. Like any medication, they can cause side effects. Here are some potential side effects associated with this medication:

  • Nausea and vomiting
  • Diarrhea
  • Headache
  • Rash or itching
  • Local reactions at the injection site, such as pain or inflammation
  • Changes in taste
  • Increased liver enzymes (seen in blood tests)
  • Allergic reactions, including severe allergic reactions (e.g., anaphylaxis) which can be life-threatening

It’s important to note that not everyone will experience these side effects, and some individuals may experience different or no side effects at all. If you experience any severe or persistent side effects, or if you have concerns about any symptoms you’re experiencing, it’s crucial to contact your healthcare provider for further evaluation and guidance.

Additionally, there may be other side effects not listed here, so it’s essential to read the medication’s package insert or consult with your healthcare provider or pharmacist for a comprehensive list of potential side effects specific to your situation. They can provide you with more detailed information based on your medical history and current medications.

What should I know about storage and disposal of this medication?


  • Follow the storage instructions provided by your pharmacist or on the medication packaging.
  • Typically, this medication should be stored at room temperature, away from excessive heat and moisture.
  • Do not freeze the medication unless instructed otherwise.


  • It is important to dispose of unused or expired medications properly to prevent accidental ingestion or environmental contamination.
  • Follow the specific disposal instructions provided by your healthcare provider, pharmacist, or local regulations.
  • In some cases, there may be designated disposal programs or medication take-back events in your community. You can inquire about these options at your local pharmacy or healthcare facility.

In case of emergency/overdose

  • In case of an emergency or suspected overdose, immediately call your local emergency number or go to the nearest emergency room.
  • If possible, bring the medication packaging or container with you to provide necessary information to healthcare professionals.

What other information should I know?

  • Inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as they can potentially interact with Imipenem, Cilastatin, and Relebactam Injection.
  • It is essential to complete the full course of treatment prescribed by your healthcare provider, even if you start feeling better before finishing the medication.
  • Attend all follow-up appointments as scheduled to monitor your progress and ensure appropriate treatment.

Remember, the above information is a general guideline, and it’s important to follow the specific instructions provided by your healthcare provider or pharmacist for the proper storage, disposal, and management of Imipenem, Cilastatin, and Relebactam Injection.

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