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Imipenem and Cilastatin Injection

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Why is this medication prescribed?

Imipenem and cilastatin injection is a medication prescribed for the treatment of severe bacterial infections. It is a combination of two drugs: imipenem and cilastatin.

Imipenem is a broad-spectrum antibiotic belonging to the carbapenem class. It works by inhibiting the growth of bacteria by interfering with their cell wall synthesis. Imipenem is effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria. It is commonly used to treat infections caused by multidrug-resistant organisms or when other antibiotics have failed.

Cilastatin is added to imipenem to prevent the breakdown of imipenem by an enzyme called dehydropeptidase I, which is found in the kidneys. By inhibiting this enzyme, cilastatin helps to increase the concentration of imipenem in the body and enhances its effectiveness.

Imipenem and cilastatin injection is typically used to treat serious infections, such as intra-abdominal infections, urinary tract infections, respiratory tract infections, skin and soft tissue infections, and gynecological infections. It may also be used in patients with a compromised immune system, such as those with neutropenia (low white blood cell count) or those who have undergone organ transplantation.

It is important to note that imipenem and cilastatin injection is a potent antibiotic and is usually reserved for severe infections that have not responded to other antibiotics. It is typically administered in a hospital setting under the supervision of a healthcare professional. The dosage and duration of treatment will be determined by the healthcare provider based on the specific infection and the patient’s condition.

How should this medicine be used?

Here are some general guidelines for using imipenem and cilastatin injection:

  • Administration: The medication is usually given by a healthcare professional, such as a nurse or doctor. It is typically administered slowly over a period of 20 to 30 minutes.
  • Dosage: The appropriate dosage will be determined by your healthcare provider based on factors such as the type and severity of the infection, your age, weight, and kidney function. It is important to follow the prescribed dosage and not exceed or miss any doses.
  • Frequency: Imipenem and cilastatin injection is usually given every 6 to 8 hours. Again, the frequency of administration will depend on the specific infection and the patient’s condition.
  • Duration of treatment: The duration of treatment will vary depending on the type and severity of the infection. It is important to complete the full course of treatment as prescribed, even if you start feeling better before the treatment is finished. Stopping the medication too soon may allow the infection to come back or lead to antibiotic resistance.
  • Medical supervision: It is crucial to receive imipenem and cilastatin injection under medical supervision. Your healthcare provider will monitor your response to the medication and may order laboratory tests to check your blood counts, liver function, and kidney function during the course of treatment.
  • Precautions: Inform your healthcare provider about any allergies or previous adverse reactions to antibiotics. It is important to mention any other medications, supplements, or herbal products you are taking, as they may interact with imipenem and cilastatin injection.

Remember, these are general guidelines, and it’s essential to follow the specific instructions given by your healthcare provider for your unique situation. Always consult your healthcare provider if you have any questions or concerns about the proper use of imipenem and cilastatin injection.

Other uses for this medicine

Apart from its primary use as an antibiotic, there are no other approved indications for imipenem and cilastatin injection. It is essential to note that this medication should only be used under the guidance and prescription of a qualified healthcare professional.

What special precautions should I follow?

When using imipenem and cilastatin injection, there are several special precautions that need to be considered:

  • Allergies: Inform your healthcare provider if you have any known allergies to imipenem, cilastatin, or any other medications, as serious allergic reactions can occur.
  • Seizure disorders: Imipenem can lower the seizure threshold, so caution is advised in individuals with a history of seizures or other neurological disorders.
  • Kidney problems: Imipenem and cilastatin injection should be used with caution in patients with impaired kidney function or those at risk of developing renal insufficiency. Dosage adjustments may be necessary.
  • Gastrointestinal issues: This medication may cause diarrhea, which could be a sign of a serious intestinal infection. If you experience persistent diarrhea, inform your healthcare provider.
  • Pregnancy and breastfeeding: Imipenem and cilastatin injection should be used during pregnancy only if clearly needed. It may pass into breast milk, so caution is advised when using it while breastfeeding.
  • Drug interactions: Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, as certain drugs may interact with imipenem and cilastatin.

It is crucial to follow your healthcare provider’s instructions carefully and report any unusual or severe side effects while using imipenem and cilastatin injection.

What special dietary instructions should I follow?

Imipenem and cilastatin injection is an antibiotic medication used to treat various bacterial infections. When it comes to dietary instructions, there are no specific dietary restrictions that need to be followed with this medication. However, it’s generally recommended to take it on an empty stomach, at least 1 hour before or 2 hours after a meal, as food may interfere with its absorption.

What should I do if I forget a dose?

If you happen to forget a dose of imipenem and cilastatin injection, it’s important to take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, it’s better to skip the missed dose and continue with your regular dosing schedule. Taking a double dose to make up for a missed one is not recommended, as it can increase the risk of side effects without providing additional benefits.

What side effects can this medication cause?

Imipenem and cilastatin injection is a combination medication used to treat severe bacterial infections. Like any medication, it can cause side effects in some individuals. Common side effects of imipenem and cilastatin injection may include:

  • Diarrhea: This is a common side effect and can range from mild to severe. It is important to stay hydrated while experiencing diarrhea.
  • Nausea and vomiting: Some individuals may experience feelings of nausea or may vomit after receiving the injection.
  • Skin rash: It is possible to develop a rash or itching as a reaction to the medication. If you notice any skin changes, it is advisable to inform your healthcare provider.
  • Headache: Some individuals may experience headaches while taking imipenem and cilastatin injection. If the headaches are severe or persistent, it is important to consult a healthcare professional.
  • Injection site reactions: Redness, pain, or swelling at the site of injection can occur. If these symptoms worsen or persist, it is advisable to seek medical attention.
  • Allergic reactions: Although rare, imipenem and cilastatin injection can cause severe allergic reactions, including difficulty breathing, swelling of the face, lips, tongue, or throat, and hives. If you experience any signs of an allergic reaction, it is important to seek immediate medical assistance.
  • Changes in laboratory tests: Imipenem and cilastatin injection can affect certain laboratory test results, such as liver function tests, kidney function tests, and blood cell counts. Your healthcare provider will monitor these parameters during treatment.

It is important to note that this is not an exhaustive list of side effects. Some individuals may experience other side effects while taking imipenem and cilastatin injection. If you have any concerns about the medication or experience any unusual symptoms, it is recommended to consult your healthcare provider for further evaluation and guidance.

What should I know about storage and disposal of this medication?


  • Imipenem and cilastatin injection should be stored at room temperature, typically between 20°C and 25°C (68°F and 77°F).
  • Keep the medication away from excessive heat, moisture, and light.
  • Do not freeze the medication.


  • Unused or expired imipenem and cilastatin injection should be properly disposed of to prevent accidental ingestion or environmental contamination.
  • Follow the specific disposal instructions provided by your healthcare provider, local waste management regulations, or community guidelines.
  • Do not flush the medication down the toilet or pour it down the drain unless instructed to do so.

In case of emergency/overdose

  • If you suspect an overdose or experience severe side effects after using imipenem and cilastatin injection, immediately contact emergency services or a poison control center.
  • Be prepared to provide information such as the dosage, time of administration, and any symptoms or reactions observed.

What other information should I know?

  • Imipenem and cilastatin injection should only be used under the guidance and prescription of a healthcare professional.
  • Inform your healthcare provider about any allergies, medical conditions, or medications you are currently taking, as they may interact with imipenem and cilastatin.
  • Follow the prescribed dosage and duration of treatment as directed by your healthcare provider. Do not exceed the recommended dose.
  • Report any new or worsening symptoms to your healthcare provider.
  • Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the medication’s safety during pregnancy and breastfeeding is not fully established.

Remember, it is crucial to consult with a healthcare professional or pharmacist for specific instructions regarding the storage, disposal, and emergency procedures related to imipenem and cilastatin injection.

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