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Gyne-Lotrimin 3 (Generic Clotrimazole Vaginal)

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Why is this medication prescribed?

Gyne-Lotrimin 3 Cream is a medication used to treat vaginal yeast infections caused by the fungus Candida albicans. It contains the antifungal agent clotrimazole, which works by stopping the growth of the fungus.

It is prescribed to relieve symptoms such as itching, burning, and discharge associated with vaginal yeast infections.

How should this medicine be used?

Gyne-Lotrimin 3 Cream, containing clotrimazole, is used to treat vaginal yeast infections. Here’s how it’s typically applied:

  • Wash your hands: Before and after applying the cream, make sure your hands are clean to prevent introducing bacteria into the vaginal area.
  • Clean the affected area: Gently wash the external vaginal area with mild soap and water, then pat it dry with a clean towel. It’s important not to apply the cream to broken or irritated skin.
  • Prepare the applicator (if provided): If Gyne-Lotrimin 3 Cream comes with an applicator, fill the applicator with the prescribed amount of cream according to your healthcare provider’s instructions or the product label.
  • Insert the cream: Lie on your back with knees bent or stand with one foot elevated. Gently insert the applicator filled with cream into the vagina as far as it will comfortably go, then slowly press the plunger to release the cream. If you’re using your finger to apply the cream, insert it into the vagina and apply the prescribed amount to the vaginal walls.
  • Dispose of the applicator (if used): If an applicator was used, discard it according to the manufacturer’s instructions. Do not flush the applicator down the toilet.
  • Wash your hands: Once you’ve finished applying the cream, wash your hands thoroughly to remove any residue.
  • Continue treatment: Follow your healthcare provider’s instructions regarding the duration of treatment. Typically, Gyne-Lotrimin 3 Cream is used once daily for three days, but your provider may recommend a different regimen based on your specific condition.
  • Avoid sexual activity: Refrain from sexual intercourse during the treatment period, as clotrimazole cream may weaken condoms and diaphragms, potentially reducing their effectiveness.

It’s important to use Gyne-Lotrimin 3 Cream exactly as prescribed by your healthcare provider or as directed on the product label. If your symptoms persist or worsen after completing the treatment, consult your healthcare provider for further evaluation and advice.

Other uses for this medicine

While Gyne-Lotrimin 3 Cream is primarily used to treat vaginal yeast infections, clotrimazole, the active ingredient, may also be used to treat other fungal infections such as athlete’s foot, jock itch, and ringworm. However, it’s essential to consult a healthcare professional before using it for any other condition.

What special precautions should I follow?

As for special precautions when using Gyne-Lotrimin 3 Cream:

  • Allergies: Inform your healthcare provider if you have any allergies to clotrimazole or any other antifungal medications.
  • Medical history: Discuss your medical history with your healthcare provider, especially if you have had liver disease, HIV/AIDS, diabetes, or a weakened immune system, as these conditions may affect your response to Gyne-Lotrimin 3 Cream.
  • Pregnancy and breastfeeding: If you are pregnant or breastfeeding, consult your healthcare provider before using Gyne-Lotrimin 3 Cream. While it’s generally considered safe to use during pregnancy, it’s essential to discuss potential risks and benefits with your healthcare provider.
  • Avoid contact with eyes: Gyne-Lotrimin 3 Cream is for vaginal use only. Avoid getting the cream in your eyes, nose, mouth, or other mucous membranes. If accidental contact occurs, rinse thoroughly with water.
  • Avoid tampons and douches: While using Gyne-Lotrimin 3 Cream, avoid using tampons, vaginal douches, or other vaginal products unless directed otherwise by your healthcare provider.
  • Use with caution with condoms and diaphragms: Clotrimazole cream may weaken latex condoms and diaphragms, potentially reducing their effectiveness. Avoid using these contraceptive methods while using the cream and for at least three days after treatment.
  • Side effects: Like any medication, Gyne-Lotrimin 3 Cream may cause side effects such as irritation, burning, itching, or rash. If you experience severe or persistent side effects, discontinue use and consult your healthcare provider.
  • Complete the course of treatment: Use Gyne-Lotrimin 3 Cream for the full prescribed duration, even if your symptoms improve before completing the treatment. Incomplete treatment may lead to recurrence or incomplete resolution of the infection.

Always follow your healthcare provider’s instructions and read the medication label carefully before using Gyne-Lotrimin 3 Cream. If you have any questions or concerns, consult your healthcare provider or pharmacist.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are typically no specific dietary restrictions associated with using Gyne-Lotrimin 3 Cream. However, maintaining a healthy and balanced diet can support overall health and immune function, which may aid in recovery from vaginal yeast infections.

What should I do if I forget a dose?

If you forget a dose of Gyne-Lotrimin 3 Cream, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one. If you have any questions or concerns about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Gyne-Lotrimin 3 Cream, containing clotrimazole as its active ingredient, may cause some side effects, although not everyone experiences them. Common side effects of Gyne-Lotrimin 3 Cream may include:

  • Local irritation: This can manifest as itching, burning, redness, or discomfort in the vaginal area where the cream is applied.
  • Allergic reactions: Some individuals may experience allergic reactions to clotrimazole, resulting in symptoms such as rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, or severe dizziness. Seek medical attention immediately if you experience any signs of an allergic reaction.
  • Vaginal discharge: You may notice changes in vaginal discharge during or after using Gyne-Lotrimin 3 Cream. This can include an increase in discharge or changes in color or consistency.
  • Abdominal pain: Some individuals may experience mild abdominal discomfort while using Gyne-Lotrimin 3 Cream.
  • Headache: Headaches are a possible side effect, although they are less common.
  • Blisters: In rare cases, the use of clotrimazole cream may cause blistering or severe skin irritation.
  • Burning sensation: A burning sensation in the vaginal area may occur in some individuals after applying the cream.
  • Skin reactions: In rare cases, individuals may experience skin reactions such as dermatitis or eczema at the site of application.

It’s important to note that these side effects are generally mild and temporary. If you experience severe or persistent side effects, discontinue use of Gyne-Lotrimin 3 Cream and consult your healthcare provider for further evaluation and guidance. Additionally, if you have any concerns about potential side effects, discuss them with your healthcare provider or pharmacist before using the medication.

What should I know about storage and disposal of this medication?

Storage and disposal of Gyne-Lotrimin Cream:


  • Store Gyne-Lotrimin 3 Cream at room temperature away from moisture, heat, and light.
  • Keep the medication out of reach of children and pets.
  • Do not freeze the cream.
  • Avoid storing the cream in the bathroom, as moisture and humidity can degrade the medication.


  • Dispose of Gyne-Lotrimin 3 Cream properly according to local regulations or guidelines.
  • Do not flush the cream down the toilet or pour it down the drain unless instructed to do so by your healthcare provider or pharmacist.
  • If you have unused or expired medication, consult your pharmacist or local waste disposal facility for guidance on safe disposal methods.

In case of emergency/overdose

  • In case of accidental ingestion of Gyne-Lotrimin 3 Cream or overdose, contact your local poison control center (in the United States, you can call 1-800-222-1222) or seek emergency medical attention immediately.
  • Be prepared to provide information about the medication ingested, the amount taken, and any symptoms experienced.

What other information should I know?

  • Follow the prescribed dosage and treatment regimen provided by your healthcare provider.
  • Do not share Gyne-Lotrimin 3 Cream with others, even if they have similar symptoms.
  • Inform your healthcare provider of any other medications or supplements you are taking to avoid potential drug interactions.
  • If your symptoms persist or worsen after completing the treatment, consult your healthcare provider for further evaluation and advice.
  • Keep the medication container tightly closed when not in use to prevent contamination.
  • Wash your hands before and after applying the cream to prevent the spread of infection.

By adhering to these guidelines for storage, disposal, and handling of Gyne-Lotrimin 3 Cream, you can ensure its effectiveness and safety while minimizing the risk of accidental ingestion, overdose, or improper disposal.

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