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Glyxambi (Generic Empagliflozin)

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Why is this medication prescribed?

Glyxambi is prescribed to treat type 2 diabetes mellitus in adults. It is a combination medication that contains two active ingredients: empagliflozin and linagliptin.

  • Empagliflozin: This component belongs to a class of medications called sodium-glucose cotransporter-2 (SGLT2) inhibitors. It works by helping the kidneys remove glucose from the bloodstream through urine, thus lowering blood sugar levels.
  • Linagliptin: This component is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the levels of incretin hormones in the body, which stimulate the release of insulin and decrease the levels of glucagon, a hormone that raises blood sugar levels.

Combining these two medications in Glyxambi helps to control blood sugar levels in individuals with type 2 diabetes when diet and exercise alone are not sufficient. It is often prescribed as part of a comprehensive treatment plan for managing diabetes, which may include lifestyle modifications, other oral medications, and/or insulin therapy.

How should this medicine be used?

Glyxambi is a prescription medication used to treat type 2 diabetes. It combines two active ingredients: empagliflozin and linagliptin. Empagliflozin belongs to a class of drugs called SGLT2 inhibitors, which work by helping the kidneys remove glucose from the bloodstream through the urine. Linagliptin belongs to a class of drugs called DPP-4 inhibitors, which work by increasing the levels of incretin hormones in the body, thereby helping to decrease blood sugar levels.

Glyxambi is typically taken orally, usually once daily with or without food. The dosage and frequency of Glyxambi will depend on individual factors such as the severity of diabetes, other medications being taken, and overall health.

It’s important to follow the dosage instructions provided by your healthcare provider and to not exceed the prescribed dose. Additionally, it’s important to regularly monitor blood sugar levels as directed by your healthcare provider while taking Glyxambi.

If you have any questions or concerns about how to use Glyxambi, it’s important to consult with your healthcare provider or pharmacist for personalized advice.

Other uses for this medicine

Glyxambi is primarily prescribed for the treatment of type 2 diabetes mellitus in adults, and there are no other approved uses for this medication. It is specifically formulated to help control blood sugar levels in individuals with type 2 diabetes when diet and exercise alone are not sufficient.

What special precautions should I follow?

As for special precautions to follow when taking Glyxambi, there are several important considerations:

  • Allergies: Before taking Glyxambi, inform your healthcare provider if you have any allergies to empagliflozin, linagliptin, or any other ingredients in the medication. Allergic reactions to Glyxambi are rare but can occur.
  • Medical History: Discuss your medical history with your healthcare provider, especially if you have a history of kidney problems, urinary tract infections, liver disease, heart failure, pancreatitis, or if you are on dialysis. These conditions may affect your ability to safely take Glyxambi.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Glyxambi during pregnancy and breastfeeding has not been established, and healthcare providers may need to adjust your treatment plan accordingly.
  • Dehydration: Glyxambi may increase the risk of dehydration, particularly in elderly individuals or those taking diuretics (water pills). Stay well-hydrated and monitor for signs of dehydration such as increased thirst, dry mouth, weakness, dizziness, or decreased urination.
  • Genital Yeast Infections: Women may be at increased risk of genital yeast infections while taking Glyxambi. Inform your healthcare provider if you experience symptoms such as vaginal itching, burning, or discharge.
  • Hypoglycemia (Low Blood Sugar): Glyxambi may increase the risk of hypoglycemia, particularly when used in combination with insulin or other medications that lower blood sugar levels. Monitor your blood sugar levels regularly and be aware of the signs and symptoms of hypoglycemia, including shakiness, dizziness, sweating, confusion, and hunger.
  • Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Glyxambi. Certain medications, such as rifampin or ritonavir, may affect how Glyxambi works or increase the risk of side effects.

Always follow your healthcare provider’s instructions and recommendations when taking Glyxambi, and do not adjust your dosage or stop taking the medication without consulting them first.

What special dietary instructions should I follow?

Regarding special dietary instructions:

  • Monitoring Carbohydrate Intake: Since Glyxambi helps lower blood sugar levels, it’s important to monitor your carbohydrate intake and maintain a balanced diet. Your healthcare provider or a registered dietitian can provide personalized dietary recommendations based on your individual needs.
  • Alcohol Consumption: Limit alcohol consumption while taking Glyxambi, as it can increase the risk of hypoglycemia and other side effects.

What should I do if I forget a dose?

If you forget a dose of Glyxambi:

  • Take it as soon as you remember: If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule.
  • Don’t double up: Do not take a double dose to make up for a missed one. Taking too much Glyxambi can increase the risk of side effects.
  • Notify your healthcare provider: If you frequently forget doses or have difficulty adhering to your medication schedule, inform your healthcare provider. They can provide strategies to help you remember your medication and ensure proper adherence to your treatment plan.

What side effects can this medication cause?

Glyxambi, like any medication, can cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. Some common side effects of Glyxambi include:

  • Urinary Tract Infections (UTIs): Increased urination caused by empagliflozin can sometimes lead to urinary tract infections. Symptoms may include burning sensation during urination, frequent urination, cloudy or bloody urine, and pelvic pain.
  • Genital Yeast Infections: Women may experience vaginal yeast infections due to changes in genital pH levels caused by empagliflozin. Symptoms may include vaginal itching, burning, unusual discharge, and discomfort during sex.
  • Increased Urination and Thirst: Empagliflozin’s mechanism of action involves increasing urinary glucose excretion, leading to increased urination and thirst in some individuals.
  • Hypoglycemia (Low Blood Sugar): Taking Glyxambi alongside other medications that lower blood sugar levels or insulin can increase the risk of hypoglycemia. Symptoms may include shakiness, sweating, confusion, dizziness, hunger, and rapid heartbeat.
  • Dehydration: Empagliflozin can cause increased urination, potentially leading to dehydration, particularly in individuals who are elderly or taking diuretic medications.
  • Orthostatic Hypotension: Some individuals may experience a drop in blood pressure upon standing (orthostatic hypotension) due to volume depletion caused by empagliflozin-induced diuresis.
  • Kidney Problems: Although uncommon, empagliflozin can sometimes cause kidney problems, especially in individuals with pre-existing kidney disease.
  • Increased Cholesterol Levels: Linagliptin, one of the components of Glyxambi, may cause an increase in cholesterol levels in some individuals.
  • Pancreatitis: Rarely, linagliptin, the DPP-4 inhibitor component of Glyxambi, has been associated with pancreatitis, an inflammation of the pancreas.
  • Allergic Reactions: While rare, allergic reactions to Glyxambi can occur. Symptoms may include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing.

It’s essential to discuss any concerns or side effects with your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment plan if necessary. Additionally, if you experience severe or persistent side effects, seek medical attention promptly.

What should I know about storage and disposal of this medication?

Regarding storage and disposal of Glyxambi:

  • Storage: Store Glyxambi at room temperature away from light and moisture. Avoid storing it in the bathroom or kitchen where it could be exposed to moisture. Keep the medication out of reach of children and pets.
  • Disposal: Dispose of unused or expired Glyxambi tablets properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them down the drain unless instructed to do so. Consult with your pharmacist or local waste disposal facility for proper disposal methods.

In case of emergency/overdose

In case of emergency or overdose of Glyxambi:

  • Seek Immediate Medical Attention: If you suspect an overdose of Glyxambi or experience severe symptoms such as confusion, seizures, unconsciousness, or difficulty breathing, call emergency services or go to the nearest emergency room immediately.
  • Provide Information: If possible, provide information about the medication ingested, including the dosage and the time it was taken.

What other information should I know?

  • Regular Monitoring: Your healthcare provider may recommend regular monitoring of blood sugar levels, kidney function, and other parameters while taking Glyxambi to ensure its effectiveness and safety.
  • Avoid Alcohol: Limit alcohol consumption while taking Glyxambi, as it can increase the risk of hypoglycemia and other side effects.
  • Medical Alert Bracelet: If you are at risk of hypoglycemia or have other medical conditions that may require emergency treatment, consider wearing a medical alert bracelet or carrying identification indicating your medical condition and the medications you are taking, including Glyxambi.
  • Follow-up: Attend regular follow-up appointments with your healthcare provider to assess your response to Glyxambi and make any necessary adjustments to your treatment plan.
  • Inform Healthcare Providers: Inform all healthcare providers involved in your care, including dentists and specialists, that you are taking Glyxambi. This information is important for ensuring safe and coordinated medical treatment.

Always follow your healthcare provider’s instructions and recommendations when taking Glyxambi, and do not hesitate to ask any questions or seek clarification about your medication regimen.

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