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Glydeine (Generic Codeine)

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Glydeine, also known as codeine, is an opioid medication used to treat pain and sometimes coughing. While it can be effective for managing certain conditions, it also carries several risks:

  • Addiction: Codeine is addictive, especially when taken in high doses or for prolonged periods. It can lead to physical and psychological dependence.
  • Respiratory depression: Taking high doses of codeine can slow down breathing to dangerous levels, particularly in individuals with respiratory issues or when combined with other depressants like alcohol or benzodiazepines.
  • Overdose: Taking too much codeine can result in an overdose, which can be life-threatening. Symptoms may include extreme drowsiness, shallow breathing, clammy skin, slowed heartbeat, and even coma.
  • Constipation: Codeine commonly causes constipation, which can be severe and require additional treatment.
  • Tolerance and dependence: Over time, individuals may develop tolerance to codeine, requiring higher doses to achieve the same effects. This can further increase the risk of addiction and overdose.
  • Withdrawal symptoms: Abruptly stopping codeine after regular use can lead to withdrawal symptoms such as anxiety, irritability, nausea, vomiting, muscle aches, and insomnia.
  • Interactions: Codeine can interact with other medications, especially other central nervous system depressants, potentially leading to dangerous effects or overdose.

Due to these risks, it’s essential to use codeine only as prescribed by a healthcare professional and to be aware of its potential dangers, especially in individuals with a history of substance abuse or respiratory problems.

Why is this medication prescribed?

Codeine, often referred to as Glydeine, is prescribed for several medical conditions, primarily to alleviate pain and suppress coughing. Here’s why it may be prescribed:

  • Pain relief: Codeine is used to manage mild to moderate pain, such as that caused by injuries, dental procedures, surgeries, or chronic conditions like arthritis.
  • Cough suppression: It is also prescribed to suppress coughing, particularly in cases where coughing is persistent or disrupting sleep. It works by reducing the brain’s urge to cough.
  • Combination therapies: Codeine is sometimes combined with other medications, such as acetaminophen (paracetamol) or ibuprofen, to enhance pain relief effectiveness. These combination drugs are often prescribed for conditions like migraines, dental pain, or menstrual cramps.

How should this medicine be used?

When using codeine, it’s crucial to follow your healthcare provider’s instructions carefully. Here are general guidelines for its use:

  • Dosage: Take codeine exactly as prescribed by your doctor. Do not take more than the recommended dose or take it more frequently than prescribed. Dosage varies depending on the severity of pain, individual response, and other factors.
  • Administration: Codeine is typically taken orally in the form of tablets or liquid. Swallow the tablets whole with a full glass of water. If you’re taking the liquid form, use a measuring device to ensure accurate dosing.
  • Timing: Take codeine as soon as you feel pain or as directed by your doctor. It can be taken with or without food, but taking it with food may help reduce stomach upset.
  • Avoid alcohol: Refrain from consuming alcohol while taking codeine, as it can increase the risk of side effects such as drowsiness, dizziness, and respiratory depression.
  • Duration of use: Use codeine for the shortest duration possible to relieve your symptoms. Prolonged use can lead to tolerance, dependence, and addiction.
  • Discontinuation: Do not stop taking codeine suddenly without consulting your doctor, as this can lead to withdrawal symptoms. Your doctor may gradually reduce your dosage to prevent withdrawal.
  • Storage: Store codeine securely out of reach of children and pets, and at room temperature away from moisture and heat.

Always consult your healthcare provider if you have any questions or concerns about the appropriate use of codeine or if you experience any adverse effects.

Other uses for this medicine

Some of these alternative uses may include:

  • Diarrhea: Codeine can be used in certain cases to help alleviate severe diarrhea, particularly when other treatments have been ineffective. It works by slowing down intestinal contractions.
  • Antitussive: In some cases, codeine may be prescribed for its cough-suppressant properties in conditions other than those officially approved, such as chronic bronchitis or whooping cough.
  • Premature ejaculation: There is some evidence to suggest that codeine may have a role in delaying ejaculation, though this use is not common and should be carefully monitored by a healthcare provider.

What special precautions should I follow?

Regarding special precautions for using codeine (Glydeine), here are some important considerations:

  • Medical history: Inform your healthcare provider about any medical conditions you have, especially respiratory issues (such as asthma or COPD), liver or kidney problems, gastrointestinal disorders, history of substance abuse, mental health disorders, or any allergies.
  • Pregnancy and breastfeeding: Codeine should be used with caution during pregnancy and breastfeeding, as it can pass through the placenta to the fetus or into breast milk. Discuss the risks and benefits with your doctor before using codeine if you are pregnant or breastfeeding.
  • Children and elderly: Codeine should be used cautiously in children and older adults, as they may be more sensitive to its effects, including respiratory depression and sedation.
  • Driving and operating machinery: Codeine can cause drowsiness, dizziness, and impair cognitive function. Avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until you know how codeine affects you.
  • Interactions: Inform your doctor about all medications, supplements, and herbal products you are taking, as codeine can interact with certain drugs, including other opioids, benzodiazepines, antidepressants, and sedatives, potentially leading to dangerous effects or overdose.
  • Avoid alcohol: Refrain from consuming alcohol while taking codeine, as it can increase the risk of side effects such as drowsiness, dizziness, and respiratory depression.

Always follow your doctor’s instructions carefully and report any unusual symptoms or concerns while taking codeine.

What special dietary instructions should I follow?

Regarding special dietary instructions for Glydeine, there are no specific dietary restrictions associated with its use. However, it’s important to maintain a balanced diet and stay hydrated while taking any medication.

What should I do if I forget a dose?

If you forget a dose of Glydeine, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Glydeine, or codeine, like all medications, can cause side effects. Common side effects of Glydeine may include:

  • Drowsiness: Codeine can cause drowsiness or sedation, which may impair your ability to perform tasks requiring alertness, such as driving or operating machinery.
  • Constipation: Codeine is known to slow down bowel movements, leading to constipation. Increasing fluid intake, dietary fiber, and physical activity can help alleviate this side effect.
  • Nausea and vomiting: Some individuals may experience nausea or vomiting when taking codeine. Taking codeine with food may help reduce these symptoms.
  • Dizziness: Codeine can cause dizziness or lightheadedness, especially when standing up quickly from a sitting or lying position.
  • Confusion: Some people may experience confusion or difficulty concentrating while taking codeine.
  • Dry mouth: Codeine may cause dry mouth, which can be alleviated by drinking water or using sugar-free gum or candies.
  • Difficulty urinating: Codeine can sometimes lead to difficulty urinating or urinary retention.
  • Itching or rash: Skin reactions such as itching or rash may occur in some individuals taking codeine.
  • Respiratory depression: In high doses or in susceptible individuals, codeine can depress the respiratory system, leading to slow or shallow breathing. This is more common in those with underlying respiratory conditions.
  • Allergic reactions: Although rare, some people may experience allergic reactions to codeine, characterized by symptoms such as hives, swelling of the face or throat, difficulty breathing, or severe dizziness.

It’s essential to monitor for any adverse effects while taking Glydeine and to report them to your healthcare provider if they persist or worsen. Additionally, seek immediate medical attention if you experience any severe or concerning symptoms, such as difficulty breathing, chest pain, or signs of an allergic reaction.

What should I know about storage and disposal of this medication?

Storage and disposal instructions for Glydeine typically include the following:


  • Keep Glydeine out of reach of children and pets, preferably in a locked cabinet or a high shelf.
  • Store it at room temperature, away from moisture and heat. Avoid storing it in the bathroom or near the kitchen sink.
  • Do not share Glydeine with others, even if they have similar symptoms or conditions.


  • Dispose of unused or expired Glydeine properly to prevent accidental ingestion by others.
  • Follow any specific disposal instructions provided by your pharmacist or local waste management authorities.
  • Do not flush Glydeine down the toilet unless instructed to do so.

In case of emergency/overdose

In case of emergency or overdose of Glydeine, take the following steps:

  • If you suspect an overdose of Glydeine, call emergency services (e.g., 911) immediately.
  • Signs of overdose may include extreme drowsiness, slow or shallow breathing, clammy skin, fainting, or loss of consciousness.
  • While waiting for help to arrive, try to keep the person awake and breathing. Do not attempt to induce vomiting unless instructed by medical professionals.
  • Be prepared to provide information about the amount of Glydeine ingested, when it was taken, and any other medications or substances the person may have consumed.

What other information should I know?

  • Follow your healthcare provider’s instructions precisely when taking Glydeine.
  • Do not exceed the recommended dosage or frequency of use without consulting your doctor.
  • Avoid consuming alcohol while taking Glydeine, as it can increase the risk of side effects.
  • Inform your doctor about all medications, supplements, and herbal products you are taking to avoid potential interactions.
  • Do not abruptly stop taking Glydeine without consulting your doctor, as withdrawal symptoms may occur.
  • Store Glydeine in its original packaging to ensure proper identification and dosing instructions.
  • Keep track of your Glydeine supply and refill it as needed to prevent running out of medication.
  • If you have any questions or concerns about Glydeine, consult your healthcare provider or pharmacist for guidance.
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