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Fycompa (Generic Perampanel)

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Perampanel users have had significant or potentially fatal changes in their mental health and behavior, including a rise in hatred or violence against others. Inform your doctor if you currently or in the past have displayed aggressive or mental illness. However, you should be aware that even if you have never before experienced issues with your mental health or behavior, you could acquire these changes while using perampanel. If you suffer any changes in mood, behavior, or personality while receiving treatment with perampanel or for up to a month after ending treatment, you, your family, or your caretaker should notify your doctor straight once. Throughout your perampanel treatment, particularly when you first start taking the drug and whenever your dose is adjusted, your doctor will keep a close eye on your mental well-being. Call your doctor right away if you see any of the following signs: hostility, aggression, rage, anxiety, irritability, suspicious or distrustful conduct, disorientation, memory issues, or thoughts of hurting or killing people or making threats to do so. Your medicine may be stopped or its dosage reduced by your doctor.

Whenever you need a prescription refill for perampanel, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

You should discuss the dangers of using perampanel with your doctor.

Why is this medication prescribed?

In adults and children aged 4 and older, perampanel is used to treat certain partial onset seizures (seizures that only affect one portion of the brain). It is also used to treat some types of primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; a seizure that affects the entire body) in adults and children 12 years of age and older in combination with other drugs. Anticonvulsants are a group of drugs that includes perampanel. It reduces the brain’s aberrant electrical activity in order to work.

How should this medicine be used?

Perampanel is available as a tablet and a suspension (liquid) that can be ingested. It is often given before bedtime, once daily. Take perampanel every day at about the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Take perampanel as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Before each use, thoroughly shake the suspension to combine the medication.

To prepare and measure your dose, always use the oral (by mouth) dosing syringe that is supplied with perampanel suspension. Don’t measure your dose with a regular spoon.

Perampanel will likely be prescribed to you at a low dosage by your doctor, who will then likely gradually raise it up to once per week.

Perampanel could lead to habit formation. Don’t take the medication in excess of what your doctor has suggested in terms of dosage, frequency, or duration.

Although it doesn’t treat your illness, perampanel may help you manage it. Without consulting your doctor, do not discontinue taking perampanel. Your seizures can get worse if you abruptly stop using perampanel. Your dose will likely be gradually reduced by your doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking perampanel,

  • If you have any allergies, including to any of the substances in perampanel tablets or the oral suspension, notify your doctor and pharmacist right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Incorporate any of the following: antidepressants, barbiturates such secobarbital (Seconal) and phenobarbital; drugs for pain, mental illness, mental illness, mental illness, allergies, anxiety, cough, cold, and seizures, including carbamazepine (Carbatrol, Tegretol, Equetro), rifampin (Rifadin); sedatives; sleeping aids; and tranquilizers; oxcarbazepine (Trileptal, Oxtellar), phenytoin (Dilantin, Phenytek), primidone (Mysoline), and topiramate (Topamax). The dosage of your drugs may need to be adjusted, and your health may need to be closely watched for any negative effects. Be sure to let your doctor know about all the drugs you are taking, even those not on this list, as many other drugs may also interact with perampanel.
  • You should be aware that levonorgestrel-containing hormonal contraceptives, such as birth control pills, patches, rings, or implants, may become less effective when perampanel is present. While taking perampanel and for one month following your final dose, use a different method of birth control. If you are unsure whether the birth control you are using contains levonorgestrel, consult your doctor or pharmacist.
  • Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
  • Inform your doctor if you regularly consume excessive amounts of alcohol, have ever used illicit drugs, or have ever taken prescription drugs in excess. If you have kidney or liver illness now or formerly had it, let your doctor know.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking perampanel.
  • You should be aware that perampanel may cause sleepiness, coordination issues, and dizziness. In particular if you are senior, this could raise your chance of significant injury-causing falls. Until you are certain of how this drug affects you, avoid operating machinery, driving a car, or engaging in other tasks that call for attentiveness or coordination.
  • Inquire with your doctor if drinking alcohol is okay for you to do while taking perampanel. Perampanel side effects can get worse after drinking alcohol.
  • You should be aware that while using perampanel, your mental health may alter in unexpected ways and you could develop suicidal thoughts (plans or attempts to hurt or kill yourself). One in 500 adults and children aged 5 years and older who were treated with anticonvulsants like perampanel for a variety of illnesses during clinical studies developed suicidal thoughts while on the medication. Some of these individuals started exhibiting suicidal thoughts and actions as little as one week after beginning the medicine. If you take an anticonvulsant drug like perampanel, there is a chance that your mental state may change, but there is also a chance that your condition will not be addressed and that your mental state will change. Whether the hazards of using an anticonvulsant drug outweigh the dangers of not using it will be decided by you and your doctor. If you experience any of the following symptoms, you should call your doctor as soon as possible. This goes for you, your family, or your caretaker. panic attacks, agitation or restlessness, fresh occurrences of, or worsening of, irritability, anxiety, or depression, acting on risky impulses, sleep difficulties, aggressive, angry, or violent behavior, mania (frenzied, abnormally excited mood), talking or thinking about wanting to harm yourself or end your life, or any other unusual changes in behavior or mood. Make sure your family or caregiver is aware of any symptoms that could be significant so they can contact the doctor on your behalf if you are unable to call for help.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Ignore the missed dose and carry on with my normal dosing routine. To make up for a missing dose, do not take a second one. Call your doctor if you miss more than one dose.

What side effects can this medication cause?

Side effects from perampanel are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Feeling unsteady or spinning
  • Drowsiness
  • Constipation
  • Nausea
  • Vomiting
  • Headache
  • Tiredness
  • Gaining weight
  • Irritability
  • Weakness
  • Difficulty coordinating
  • Back, joint, or muscular pain
  • Lowered touch or sensory sensitivity
  • Double or blurry vision

Some adverse effects can be very harmful. Stop taking perampanel and contact your doctor right away, or seek emergency medical attention, if you develop any of the symptoms mentioned below, together with those in the IMPORTANT WARNING and SPECIAL PRECAUTIONS sections:

  • Hives, rash, fever, swollen glands, face or leg swelling, shortness of breath, yellow skin or eyes, or black urine

Other negative effects of perampanel could exist. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. Don’t let the suspension freeze. Any unused suspension should be thrown away 90 days after the bottle is first opened.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the easiest approach to get rid of your medication. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of overdose may include the following:

  • Dizziness
  • Unexpected alterations in mood or conduct
  • Agitation
  • Aggressive conduct

What other information should I know?

Keep all of your doctor’s appointments.

No one else should take your medication. Perampanel is a drug under supervision. Only a limited amount of refills are permitted for prescriptions; if you have any doubts, speak with your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Fycompa®
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