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Fyarro (Generic Sirolimus (with albumin) Injection)

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Why is this medication prescribed?

A specific type of epithelioid cell tumor (soft tissue cancer that can develop in any area of the body) that has spread to surrounding tissues or to other sections of the body or cannot be eliminated by surgery is treated with sirolimus (with albumin) injection. Kinase inhibitors are a class of drugs that includes sirolimus. It functions by impeding the aberrant protein’s ability to direct the growth of cancer cells. This might aid in reducing tumor growth.

How should this medicine be used?

Sirolimus (with albumin) injection is available as a liquid suspension that must be administered intravenously (slowly injected into a vein) over the course of 30 minutes. In a doctor’s office or infusion facility, it is typically administered by a nurse or doctor. Injections of sirolimus (with albumin) are typically administered on days 1 and 8 of a 21-day cycle.

Depending on how you respond to the drug and any side effects you have, your doctor may need to stop, modify, or interrupt your therapy. During your treatment, be careful to let your doctor know how you are feeling.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving sirolimus (with albumin) injection,

  • If you have any allergies, including to any other medications, sirolimus (Fyarro, Rapamune), other rapamycin derivatives such everolimus (Afinitor, Zortress), temsirolimus (Torisel), any other drugs, or any of the ingredients in sirolimus (with albumin) injection, notify your doctor and pharmacist right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any vitamins, nutritional supplements, herbal items, and prescription and over-the-counter medicines you are now taking or intend to take. Any of the following should be mentioned: boceprevir, bromocriptine, carbamazepine, cimetidine, cisapride, clarithromycin, clotrimazole, cyclosporine, danazol, and diltiazem, telaprevir, telithromycin, troleandomycin, verapamil, or voriconazole; erythromycin; indinavir; itraconazole; ketoconazole; metoclopramide; phenobarbital; phenytoin; rifabutin; rifampin; rifapentine; ritonavir; or voriconazole. Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects. It’s important to inform your doctor about all of the medications you are taking, even those that do not appear on this list, as many other drugs may also interact with sirolimus (with albumin) injection.
  • Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
  • Inform your doctor if you have ever experienced liver or renal issues, high cholesterol, high blood potassium levels, diabetes, or high cholesterol.
  • You should be aware that sirolimus (with albumin) injection can affect a man’s ability to produce sperm. But you shouldn’t automatically presume that you can’t conceive someone else. If you are pregnant or want to become pregnant, let your doctor know. To ensure that you are not pregnant when you start getting sirolimus (with albumin) injection, your doctor may run a pregnancy test. Use an effective method of birth control to avoid getting pregnant while receiving sirolimus (with albumin) injection therapy and for three months following your last dosage. Discuss effective birth control options with your doctor. Call your doctor if you conceive while having an albumin-containing sirolimus injection. The fetus may be harmed by sirolimus (with albumin) injection.
  • Knowing that sirolimus (with albumin) injection may raise glucose levels is important if you have diabetes. During the course of your therapy with (with albumin) injection, your doctor may advise you to check your blood sugar levels more regularly.
  • Inform the surgeon or dentist that you are receiving a sirolimus (with albumin) injection if you are undergoing surgery, including dental surgery.
  • Avoid getting any shots without first consulting your doctor.

What special dietary instructions should I follow?

Grapefruit and grapefruit juice should not be consumed in significant quantities while using this medication.

What side effects can this medication cause?

The injection of sirolimus (with albumin) may have unwanted effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Constipation
  • Mouth ache
  • Hemorrhoids
  • Shift in preference
  • Fatigue
  • Headache
  • Hair fall
  • Reduction in appetite
  • Slim down
  • Neck, back, or muscle pain
  • Inability to sleep

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Ulcers on the lips or in the mouth.
  • Fever, chills, a sore throat, or other symptoms of infection
  • Cough, breathlessness, or labored breathing
  • Trouble peeing, lower back pain, or pain or burning when urinating
  • Unusual bleeding or bruises, tarry, bloody, or red feces, bloody or brown vomit that resembles coffee grounds, and coughing up or vomiting
  • Scaly, red, cracked, and swollen skin
  • Hives
  • Rash
  • Itching
  • Breathing or swallowing challenges
  • Edema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
  • Hoarseness

Other negative effects from sirolimus (with albumin) injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor how your body is responding to the injection of sirolimus (with albumin), your doctor will request a few lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Fyarro®
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