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Frova (Generic Frovatriptan)

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Why is this medication prescribed?

The medication frovatriptan is used to treat migraine headaches, which are characterized by intense throbbing headaches, nausea, and sometimes sensitivity to light and sound. As a selective serotonin receptor agonist, flovatriptan belongs to a group of drugs. It operates by constricting blood arteries surrounding the brain, preventing pain signals from reaching the brain, and halting the production of specific natural compounds that produce pain, nausea, and other migraine symptoms. Both migraine attacks and the amount of headaches you experience do not get better with frovatriptan.

How should this medicine be used?

Frovatriptan is available as an oral tablet. It is typically given as soon as a migraine headache appears. Take a second pill if necessary if your symptoms subside after taking frovatriptan but return in two hours or more. Don’t take a second tablet of frovatriptan before calling your doctor, though, if your symptoms do not get better after taking the medication. In a 24-hour period, don’t take more than three frovatriptan tablets. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Frovatriptan should only be used as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Your first dose of frovatriptan can be administered in a clinic, hospital, or another setting where you can be watched closely for negative effects.

If your headaches do not improve or become more common after taking frovatriptan, contact your doctor right away.

Your headaches may worsen or become more common if you use frovatriptan more regularly or for a longer duration than is advised. No more than 10 days per month should be spent taking frovatriptan or any other headache medication. If you need to take frovatriptan to cure more than four headaches in a month, call your doctor right away.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking frovatriptan,

  • If you have any allergies, including to drugs, foods, or any of the substances in frovatriptan tablets, notify your doctor right once. Request a list of the components from your pharmacist.
  • If you have taken any of the following drugs within the previous 24 hours, avoid taking frovatriptan: Other selective serotonin receptor agonists include sumatriptan (Imitrex, in Treximet), rizatriptan (Maxalt), eletriptan (Relpax), almotriptan (Axert), and zolmitriptan (Zomig); bromocriptine (Parlodel), cabergoline, dihydroergotamine (D.H.E. 45, Migranal), ergoloid mesylates (Hydergine), ergonovine (Ergotrate), ergotamine (Cafergot, Ergomar), methylergonovine (Methergine), methysergide (Sansert), and pergolide (Permax).
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: antidepressants including amitriptyline (Elavil), amoxapine (Asendin), and clomipramine (Anafranil), as well as acetaminophen (Tylenol); Nortriptyline (Aventyl, Pamelor), imipramine (Tofranil), doxepin (Adapin, Sinequan), protriptyline (Vivactil), and trimipramine (Surmontil); oral contraceptives (birth control pills); propranolol (Inderal); aspirin; various nonsteroidal anti-inflammatory drugs (NSAIDS) include ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn); citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine, paroxetine (Paxil), and sertraline (Zoloft) are examples of selective serotonin reuptake inhibitors (SSRIs); desvenlafaxine (Pristiq), duloxetine (Cymbalta), sibutramine (Meridia), and venlafaxine (Effexor) are examples of selective serotonin/norepinephrine reuptake inhibitors (SNRIs). Also let your doctor or pharmacist know if you’ve recently stopped taking any of the following drugs: tranylcypromine (Parnate), isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl), and phenelzine (Nardil). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have or have ever had heart disease, a heart attack, angina (chest pain), irregular heartbeats, a stroke or “mini-stroke,” or circulation issues like varicose veins, blood clots in the legs, Raynaud’s disease (problems with blood flow to the fingers, toes, ears, and nose), or ischemic bowel disease (bloody diarrhea and stomach pain caused by decreased blood flow to the intestines), let your doctor know. You could be advised by your doctor not to take frovatriptan.
  • Inform your doctor if you smoke, are obese, have ever had high blood pressure, high cholesterol, diabetes, or liver disease, have recently experienced menopause (a change in your hormonal balance), or if any members of your family have ever experienced heart disease or a stroke.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. If you intend to engage in sexual activity while taking this medicine, discuss birth control options with your doctor. Call your doctor if you become pregnant while taking frovatriptan.
  • You should be aware that frovatriptan may cause you to feel lightheaded or sleepy. Prior to understanding how this drug affects you, avoid using machinery or driving a car.
  • To ensure that your headaches are caused by migraine, discuss your symptoms with your doctor. Hemiplegic, basilar, or other types of migraines (including cluster headaches) shouldn’t be treated with frovatriptan.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

There may be negative effects from frovatriptan. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Dizziness
  • Headache
  • Mouth ache
  • Indigestion
  • Drowsiness
  • Extreme fatigue
  • Flushing
  • Temperature feeling
  • Aching bones or joints

Some adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Stiffness, discomfort, pressure, or heaviness in the neck, jaw, chest, or throat
  • Breathing difficulty
  • Developing a chilly sweat
  • Lightheadedness
  • Slow or challenging speech
  • Faintness
  • An arm or leg that is weak or numb
  • Strong or sudden stomach discomfort
  • Bloody stools
  • Constipation
  • Unexpected loss of weight
  • Vomiting
  • Irregular, hammering, or quick heartbeat
  • Breathing or swallowing challenges
  • The fingers and toes are pale or bluish in color
  • Hands or feet tingling, burning, or pain
  • Edema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
  • Hoarseness
  • Hives
  • Rash
  • Itching

Other negative effects of frovatriptan are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the easiest approach to get rid of your medication. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments. Regular blood pressure checks are advised.

When you experience headaches and when you take fovatriptan, you should record such events in a headache journal.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Frova®
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