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Fremanezumab-vfrm Injection

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Why is this medication prescribed?

The injection fremanezumab-vfrm is used to lessen the frequency of migraines, which are intense, throbbing headaches that can occasionally be accompanied by nausea and sensitivity to light or sound. The drug fremanezumab-vfrm injection belongs to the monoclonal antibody drug class. It functions by preventing the body’s natural material from acting in a way that results in migraine headaches.

How should this medicine be used?

Both a solution (liquid) in a prefilled syringe and a prefilled autoinjector are available for the injection of fremanezumab-vfrm subcutaneously (under the skin). Typically, it is injected once per month (as a single dose) or three times per year (as three distinct injections given one after the other). Use fremanezumab-vfrm injectable every one to three months, depending on your dose, on or around the same day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Exactly as instructed, administer fremanezumab-vfrm injection. Use only as directed by your doctor, neither more nor less of it, nor more frequently.

You might be able to administer the medication yourself at home, or you might ask a friend or family member to do it for you. Ask your doctor to demonstrate how to inject the medication to you or the person giving the shots.

The prefilled syringe and autoinjector versions of the fremanezumab-vfrm injection are available. Before administering the drug, give the syringe and autoinjector 30 minutes to warm to room temperature away from direct sunlight. The medication should not be warmed in any other ways, including the microwave, hot water, or any other manner. Only use one syringe or autoinjector per solution, and inject the entire contents of the syringe or autoinjector. Use a container that won’t puncture to dispose of used syringes or the autoinjector. Regarding how to get rid of the puncture-resistant container, see your physician or pharmacist.

Fenonezumab-vfrm should be injected into the upper arm, stomach, or thigh. Injecting into skin that is soft, thick, bruised, red, scaly, hard, or that contains scars or stretch marks is not advised.

Before injecting fremanezumab-vfrm, always have a look at it. It need to be transparent and colorless. If the fremanezumab-vfrm injection is colored, hazy, has flakes, or has solid particles in it, do not use it. Never shake it.

Use a different syringe or autoinjector for each injection if your doctor instructs you to administer three different shots consecutively. Make sure that each injection is not administered at the exact same location as the others if you administer them at the same body site (upper arm, thigh, or stomach).

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using fremanezumab-vfrm injection,

  • If you have an allergy to fremanezumab-vfrm, any other drugs, or any of the ingredients in fremanezumab-vfrm injection, notify your doctor right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while receiving fremanezumab-vfrm injection.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you don’t remember to take your medication at the scheduled time, take it as soon as you do. From the day of your last dose forward, resume your dosing regimen.

What side effects can this medication cause?

The injection of fremanezumab-vfrm may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Pain, erythema, or edema at the injection location

When they start to manifest up to a month following your injection, some side effects can be very significant. Call your doctor right away or seek emergency medical attention if you have any of these symptoms:

  • Swelling in your mouth, throat, tongue, or face
  • Breathing challenges
  • Rash
  • Itching
  • Hives

Other negative effects of the injection of fremanezumab-vfrm are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly wrapped, away from children, and in the original container it came in. Do not freeze it; instead, keep it in the refrigerator. The drug may be kept at room temperature in the original carton for up to 24 hours after being taken out of the fridge. If the fremanezumab-vfrm injection has been stored at room temperature for longer than 24 hours, dispose of it.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

To make sure that pets, kids, and other people cannot take leftover pharmaceuticals, they should be disposed of in a specific manner. You shouldn’t flush this medication down the toilet, though. The best option to get rid of your medication is instead through a medication take-back program. To find out about take-back initiatives in your neighborhood, speak with your pharmacist or get in touch with your city’s waste/recycling department. If you do not have access to a take-back program, you can find more information at the FDA’s Safe Disposal of Medicines website (

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Ajovy®
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