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Why is this medication prescribed?

Adults with human immunodeficiency virus (HIV) infection who have failed to respond to previous medications, including their current regimen, are treated with fostemsavir in combination with other drugs. The drug fostemsavir belongs to a group of drugs known as HIV attachment inhibitors. It functions by lowering the level of HIV in the blood. Although fostemsavir does not treat HIV, it may lessen your risk of contracting AIDS and other HIV-related diseases such serious infections or cancer. The risk of transmitting (spreading) the HIV virus to others may be reduced by taking these medications, engaging in safer sexual behavior, and changing other aspects of one’s lifestyle.

How should this medicine be used?

A tablet form of foamesavir is available for oral consumption with or without food. Usually, it is taken twice a day. Fuzemsavir should be taken every day at roughly the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. As recommended, take the medication fostemsavir. Never take it in quantities or frequencies other than those recommended by your doctor.

Do not split, chew, or crush the tablets; rather, swallow them whole.

While controlling HIV, fostemsavir does not treat it. Even if you are feeling fine, keep taking fostemsavir. Without consulting your doctor, do not discontinue taking fostemsavir. It may be more challenging to treat your disease if you skip doses or stop taking fostemsavir.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking fostemsavir,

  • If you have an allergy to fostemsavir, any other medications, or any of the ingredients in fostemsavir tablets, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
  • Inform your physician if you are taking any of the following drugs: rifampin (Rifadin, Rimactane), carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), enzalutmide (Xtandi), mitotane (Lysodren), phenytoin (Dilantin, Phenytek), or St. John’s wort. If you are currently on one or more of these drugs, your doctor will likely advise you not to use fostemsavir.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Be sure to mention hormonal contraceptives (birth control pills, patches, rings, or injections), atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), and grazoprevir (in Zepatier), simvastatin (Flolipid, Zocor, in Vytorin), rosuvastatin (Crestor, Ezallor), pitivastatin (Livalo, Zypitamag), or voxilaprevir (in Vosevi) are examples of these medications. Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects. Be sure to inform your doctor of all the drugs you are taking, even those not on this list, as many other drugs may also interact with fostemsavir.
  • Inform your doctor if you have or have ever had a prolonged QT interval, an uncommon cardiac condition that can result in dizziness or an erratic pulse. Additionally, let your doctor know if you currently have, ever had, or have any other liver diseases. Hepatitis is a viral infection of the liver.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking fostemsavir. If you have HIV or are taking fostemsvir, you shouldn’t breastfeed.
  • You should be aware that while you use medications to treat your HIV infection, your immune system could become more powerful and start to combat other infections that were previously present in your body. You could become ill with those infections as a result of this. After beginning your fostemsavir therapy, be sure to let your doctor know if you experience any new or worsening symptoms.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Fotemsavir might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Indigestion
  • Headache
  • Tiredness
  • Rash
  • Having trouble falling or staying asleep

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or symptoms:

  • Fainting, feeling woozy, or having an erratic heartbeat

Other adverse effects of foamesavir are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

To make sure that pets, kids, and other people cannot take leftover pharmaceuticals, they should be disposed of in a specific manner. You shouldn’t flush this medication down the toilet, though. The best option to get rid of your medication is instead through a medication take-back program. To find out about take-back initiatives in your neighborhood, speak with your pharmacist or get in touch with your city’s waste/recycling department. If you do not have access to a take-back program, you can find more information at the FDA’s Safe Disposal of Medicines website (

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to fostemsavir, your doctor will request specific lab tests.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

The smell of the fostemsavir tablets could be mildly vinegar-like. If you have any questions about your medication, ask your pharmacist.

You should keep a written record of every drug you take, including prescription and nonprescription (over-the-counter) medications, vitamins, minerals, and other dietary supplements. Every time you see a doctor or are admitted to the hospital, you should carry this list with you. Additionally, it is crucial to have this knowledge on hand in case of emergency.

Brand names

  • Rukobia®
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