Why is this medication prescribed?

Fostemsavir is a prescription medication used in the treatment of HIV infection. It belongs to a class of drugs known as attachment inhibitors. Fostemsavir works by blocking the entry of HIV into immune cells, thus preventing the virus from replicating and spreading throughout the body.

Fostemsavir is typically prescribed for individuals who have multidrug-resistant HIV-1 infection and have exhausted other treatment options. It is often used in combination with other antiretroviral medications as part of an HIV treatment regimen.

How should this medicine be used?

The usage of Fostemsavir is typically as follows:

• Dosage: The recommended dose of Fostemsavir is 600 mg twice daily, taken orally with or without food.
• Administration: Fostemsavir tablets should be swallowed whole with a glass of water. They should not be crushed, chewed, or broken.
• Combination therapy: Fostemsavir is usually prescribed along with other antiretroviral medications as part of a comprehensive HIV treatment regimen. Your healthcare provider will determine the most suitable combination of medications based on your individual medical history, viral resistance profile, and other factors.
• Adherence: It is essential to take Fostemsavir exactly as prescribed by your healthcare provider. Skipping doses or not following the prescribed regimen may reduce the effectiveness of the medication and increase the risk of developing drug resistance.
• Monitoring: Regular monitoring of your HIV viral load and CD4 cell count is necessary to assess the effectiveness of the treatment and adjust the regimen if needed.
• Side effects: Like any medication, Fostemsavir may cause side effects. Common side effects include nausea, diarrhea, headache, fatigue, and abdominal pain. Inform your healthcare provider if you experience any adverse reactions while taking Fostemsavir.

It’s crucial to consult with a healthcare professional for personalized medical advice and treatment recommendations regarding the use of Fostemsavir or any other medication.

Other uses for this medicine

Fostemsavir is primarily used for the treatment of HIV infection, particularly in individuals who have multidrug-resistant HIV-1 infection and have exhausted other treatment options. As such, its primary use is limited to this indication.

What special precautions should I follow?

Regarding special precautions for Fostemsavir, here are some important points to consider:

• Resistance Testing: Before starting Fostemsavir treatment, it’s essential to undergo resistance testing to determine the sensitivity of your HIV strain to this medication. Fostemsavir should only be used in individuals with HIV-1 strains that are susceptible to it.
• Allergic Reactions: Inform your healthcare provider if you have a history of hypersensitivity or allergic reactions to Fostemsavir or any of its components. Allergic reactions to medications can be severe and may require immediate medical attention.
• Drug Interactions: Fostemsavir may interact with other medications, including certain antiretrovirals and drugs metabolized by CYP3A enzymes. Inform your healthcare provider about all the medications, supplements, and herbal products you are taking to avoid potential interactions.
• Pregnancy and Breastfeeding: The safety of Fostemsavir during pregnancy and breastfeeding has not been established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Fostemsavir treatment with your healthcare provider.
• Liver Function: Fostemsavir may affect liver function. Regular monitoring of liver function tests is recommended, especially in individuals with pre-existing liver conditions or risk factors for liver disease.
• Immune Reconstitution Inflammatory Syndrome (IRIS): In some HIV-infected individuals with severe immune deficiency, initiation of antiretroviral therapy may lead to the development of IRIS, a condition characterized by inflammatory responses to pre-existing infections. Monitor for signs and symptoms of IRIS during Fostemsavir treatment.
• Adherence: It is crucial to take Fostemsavir exactly as prescribed by your healthcare provider. Skipping doses or not following the prescribed regimen may lead to treatment failure and the development of drug resistance.
• Side Effects: Like all medications, Fostemsavir may cause side effects. Common side effects include nausea, diarrhea, headache, fatigue, and abdominal pain. Inform your healthcare provider if you experience any adverse reactions while taking Fostemsavir.

Always follow your healthcare provider’s instructions and consult them for personalized advice regarding the use of Fostemsavir and any necessary precautions.

What special dietary instructions should I follow?

Regarding special dietary instructions for Fostemsavir, it can be taken with or without food, so no specific dietary restrictions are necessary. However, maintaining a balanced and healthy diet is generally recommended for overall well-being, especially for individuals living with HIV.

What should I do if I forget a dose?

• Take the missed dose as soon as you remember, unless it’s almost time for the next scheduled dose.
• If it’s almost time for the next dose, skip the missed dose and continue with the regular dosing schedule.
• Do not take a double dose to make up for the missed one.
• If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Fostemsavir, like any medication, can cause side effects. Not everyone experiences these side effects, and their severity can vary from person to person. Common side effects of Fostemsavir may include:

• Nausea
• Diarrhea
• Headache
• Fatigue
• Abdominal pain
• Rash

These side effects are usually mild to moderate in severity and may improve over time as your body adjusts to the medication. However, if any of these side effects persist or worsen, it’s important to inform your healthcare provider.

In addition to these common side effects, Fostemsavir may also cause more serious side effects in some individuals. These can include:

• Severe allergic reactions: Symptoms may include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing. Seek immediate medical attention if you experience any signs of a severe allergic reaction.
• Liver problems: Fostemsavir may affect liver function, leading to symptoms such as yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or persistent nausea/vomiting. Contact your healthcare provider if you experience any signs of liver problems.
• Immune Reconstitution Inflammatory Syndrome (IRIS): In some individuals with advanced HIV infection, starting antiretroviral therapy (including Fostemsavir) may trigger an inflammatory response to pre-existing infections, known as IRIS. Symptoms may include fever, swollen lymph nodes, or worsening symptoms of infections. Inform your healthcare provider if you experience any signs of IRIS.

It’s important to report any side effects or concerns to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment regimen if necessary. Additionally, do not stop taking Fostemsavir without consulting your healthcare provider, as discontinuing antiretroviral therapy can lead to viral resistance and treatment failure.

What should I know about storage and disposal of this medication?

Storage and Disposal of Fostemsavir:

• Storage:
  • Store Fostemsavir tablets at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep the medication in its original container, tightly closed, and away from moisture and heat.
  • Do not store Fostemsavir in the bathroom or in places where it might be exposed to moisture or extreme temperatures.
  • Keep Fostemsavir out of reach of children and pets.
• Disposal:
  • Dispose of any unused or expired Fostemsavir tablets properly.
  • Follow local regulations or guidelines for medication disposal. You can check with your pharmacist or local waste disposal facility for instructions on how to dispose of medications safely.
  • Do not flush Fostemsavir tablets down the toilet unless instructed to do so by the medication disposal instructions or local regulations.

In case of emergency/overdose

• In case of emergency or suspected overdose with Fostemsavir, contact your local poison control center (in the United States, you can call 1-800-222-1222) or seek immediate medical attention.
• If possible, bring the medication bottle or packaging to provide information about the medication ingested.

What other information should I know?

• Keep all appointments with your healthcare provider for regular monitoring and follow-up.
• Inform all healthcare providers involved in your care (including dentists and pharmacists) that you are taking Fostemsavir.
• Do not share Fostemsavir with others, as it is prescribed based on individual medical conditions and needs.
• Continue taking Fostemsavir as prescribed, even if you feel well, to keep the HIV infection under control. Stopping the medication abruptly can lead to viral rebound and treatment failure.

It’s important to follow these guidelines for storage, disposal, and emergency situations to ensure the safe and effective use of Fostemsavir. If you have any questions or concerns about the medication, don’t hesitate to discuss them with your healthcare provider or pharmacist.