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Why is this medication prescribed?

Fostamatinib is a medication used to treat thrombocytopenia in adults with chronic immune thrombocytopenia (ITP) who have had an insufficient response to other treatments. ITP is a condition characterized by a low platelet count, which can lead to an increased risk of bleeding.

The medication works by inhibiting spleen tyrosine kinase (SYK), which plays a role in the destruction of platelets. By blocking SYK, fostamatinib helps to increase platelet counts in individuals with ITP.

How should this medicine be used?

Fostamatinib is typically taken orally in the form of tablets. The dosage and frequency of administration will be determined by a healthcare provider based on factors such as the patient’s medical history, severity of the condition, and response to treatment.

Generally, the recommended starting dose of fostamatinib is 100 mg twice daily, which may be adjusted based on individual response and tolerability. It’s important to follow the prescribed dosage and administration instructions provided by the healthcare provider.

Patients should take fostamatinib with food to help reduce the risk of gastrointestinal side effects. It’s important to swallow the tablets whole and not crush, break, or chew them.

As with any medication, it’s essential to adhere to the prescribed regimen and attend follow-up appointments with the healthcare provider to monitor progress and manage any potential side effects or complications.

Other uses for this medicine

Fostamatinib is primarily approved for the treatment of chronic immune thrombocytopenia (ITP) in adults who have had an insufficient response to other therapies. However, there may be ongoing research or off-label uses for fostamatinib in other conditions. It’s essential to consult a healthcare provider for information about any potential alternative uses of fostamatinib.

What special precautions should I follow?

When taking fostamatinib, there are several special precautions to consider:

  • Allergies: Inform your healthcare provider if you have any allergies to fostamatinib or any of its ingredients.
  • Medical History: Provide your healthcare provider with your complete medical history, especially if you have a history of liver problems, high blood pressure, bleeding disorders, or infections.
  • Medication Interactions: Inform your healthcare provider about all medications, vitamins, and supplements you are currently taking to avoid potential interactions with fostamatinib. Some drugs may interact with fostamatinib, affecting its effectiveness or increasing the risk of side effects.
  • Pregnancy and Breastfeeding: Fostamatinib may cause harm to a developing fetus, so it’s crucial to inform your healthcare provider if you are pregnant or planning to become pregnant. Additionally, it’s essential to discuss the potential risks and benefits of taking fostamatinib while breastfeeding.
  • Liver Function Monitoring: Regular monitoring of liver function tests may be necessary during fostamatinib treatment due to the potential risk of liver toxicity. Your healthcare provider will determine the appropriate monitoring schedule based on your individual circumstances.
  • Blood Pressure Monitoring: Fostamatinib may cause an increase in blood pressure, so blood pressure should be monitored regularly during treatment. Inform your healthcare provider if you experience any symptoms of high blood pressure, such as headaches, dizziness, or visual changes.
  • Infections: Fostamatinib may increase the risk of infections, so it’s essential to promptly report any signs or symptoms of infection to your healthcare provider, such as fever, chills, cough, or difficulty breathing.
  • Bleeding Risk: Since fostamatinib works by affecting platelet function, there is a risk of bleeding. It’s important to inform your healthcare provider if you experience any signs of bleeding, such as easy bruising, nosebleeds, or prolonged bleeding from cuts.

Always follow your healthcare provider’s instructions and recommendations regarding fostamatinib treatment, and do not hesitate to ask any questions or raise concerns about your treatment plan.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Fostamatinib. However, taking Fostamatinib with food may help reduce the risk of gastrointestinal side effects. Therefore, it’s generally recommended to take Fostamatinib with food. If you have any concerns about your diet while taking Fostamatinib, consult your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you miss a dose of Fostamatinib, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure about what to do, contact your healthcare provider or pharmacist for guidance. It’s important to maintain a consistent dosing schedule to ensure the effectiveness of the medication.

What side effects can this medication cause?

Fostamatinib, like any medication, can cause side effects. Common side effects of Fostamatinib may include:

  • Diarrhea: This is one of the most common side effects of Fostamatinib. It may range from mild to severe.
  • Hypertension (High Blood Pressure): Fostamatinib can cause an increase in blood pressure. Regular monitoring of blood pressure is essential during treatment.
  • Nausea and Vomiting: Some individuals may experience nausea or vomiting while taking Fostamatinib.
  • Elevated Liver Enzymes: Fostamatinib can affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function tests is usually recommended during treatment.
  • Headache: Headaches are another common side effect reported by individuals taking Fostamatinib.
  • Fatigue: Some people may experience fatigue or tiredness while taking Fostamatinib.
  • Dizziness: Fostamatinib may cause dizziness in some individuals.
  • Upper Respiratory Tract Infections: Infections of the upper respiratory tract, such as the common cold, may occur more frequently in individuals taking Fostamatinib.
  • Decreased Appetite: Some individuals may experience a decrease in appetite while taking Fostamatinib.
  • Abdominal Pain: Pain or discomfort in the abdominal area may occur as a side effect of Fostamatinib.
  • Rash: Skin rash or itching may occur in some individuals.
  • Bruising and Bleeding: Since Fostamatinib affects platelet function, there may be an increased risk of bruising or bleeding.
  • Joint Pain: Some individuals may experience joint pain or discomfort while taking Fostamatinib.

It’s important to note that not all individuals will experience these side effects, and some may experience side effects not listed here. Additionally, the severity and frequency of side effects can vary from person to person. If you experience any bothersome or persistent side effects while taking Fostamatinib, it’s important to inform your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Fostamatinib:


  • Store Fostamatinib tablets at room temperature, away from moisture and heat.
  • Keep the medication in its original container with the lid tightly closed.
  • Store Fostamatinib out of reach of children and pets, as accidental ingestion can be harmful.
  • Do not store Fostamatinib in the bathroom, as moisture and humidity can affect its stability.
  • If you have any questions about storage, consult your healthcare provider or pharmacist.


  • Dispose of expired or unused Fostamatinib tablets properly according to local guidelines or medication take-back programs.
  • Do not flush Fostamatinib down the toilet or pour it down the drain unless instructed to do so by a healthcare professional or local waste disposal authority.
  • If you are unsure about how to dispose of Fostamatinib, consult your pharmacist or healthcare provider for guidance.

In case of emergency/overdose

  • In case of an overdose of Fostamatinib, seek emergency medical attention or contact a poison control center immediately.
  • Symptoms of overdose may include severe diarrhea, vomiting, dizziness, fainting, or difficulty breathing.
  • Do not attempt to induce vomiting unless instructed to do so by a healthcare professional.

What other information should I know?

  • Keep all appointments with your healthcare provider for monitoring and management of your condition while taking Fostamatinib.
  • Inform all healthcare providers involved in your care that you are taking Fostamatinib, including dentists and pharmacists.
  • It’s important to follow all instructions provided by your healthcare provider regarding dosing, dietary considerations, and monitoring while taking Fostamatinib.
  • Report any new or worsening symptoms to your healthcare provider promptly.
  • Carry a list of all your medications, including Fostamatinib, with you in case of emergencies.
  • Avoid consuming grapefruit or grapefruit juice while taking Fostamatinib, as it may interact with the medication.

As always, if you have any questions or concerns about Fostamatinib or its use, consult your healthcare provider or pharmacist for further information and guidance.

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