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Folotyn (Generic Pralatrexate Injection)

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Why is this medication prescribed?

After receiving treatment with various drugs, peripheral T-cell lymphoma (PTCL; a type of cancer that starts in specific immune system cells) that has not improved or returned is treated with pralatrexate injection. There is no evidence that pralatrexate injection prolongs the lives of lymphoma patients. The drug pralatrexate injection belongs to the group of drugs known as folate analogue metabolic inhibitors. It eliminates cancer cells to work.

How should this medicine be used?

In a hospital or clinic, a doctor or nurse will administer pralatrexate injection as an intravenous (into a vein) solution. It is typically administered once a week for 6 weeks throughout a 7-week cycle, lasting 3 to 5 minutes total. The likelihood is that you will receive therapy until your condition deteriorates or you experience major side effects.

If you have certain adverse effects, your doctor may need to change your dose, skip a dose, or stop your therapy. During your pralatrexate injection therapy, be sure to let your doctor know how you are feeling.

To assist prevent some adverse effects, you must take folic acid and vitamin B12 while receiving treatment with pralatrexate injection. Your doctor would probably advise you to consume folic acid every day for 30 days following the last dose of pralatrexate injection, starting 10 days prior to the commencement of your treatment. As long as your medication is in effect, your doctor will likely also inform you that you must have vitamin B12 injections every 8 to 10 weeks and no more than 10 weeks prior to your first dosage of pralatrexate.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving pralatrexate injection,

  • If you have an allergy to pralatrexate injection, any other medications, any of the ingredients in pralatrexate injection, or any combination of these, notify your doctor right away. Request a list of the ingredients from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Any of the following should be mentioned: aspirin, other NSAIDS such ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), probenecid (Probalan), and trimethoprim/sulfamethoxazole (Bactrim); and probenecid. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have or have previously had renal or liver illness, let your doctor know.
  • If you think you might be pregnant or if you intend to get pregnant, inform your doctor right away. Pregnancy should not occur while a patient is getting pralatrexate injection. Consult your physician about birth control options you can use while undergoing treatment. Call your doctor right away if you get pregnant while having pralatrexate injection. The fetus could suffer from pralatrexate injection.
  • Inform your doctor or dentist that you are receiving pralatrexate injection if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Side effects from pralatrexate injection could exist. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Reduction in appetite
  • Tiredness
  • Weakness
  • Rash
  • Itching
  • Morning sweats
  • Back, leg, arm, or stomach ache
  • Edema of the lower legs, ankles, feet, or hands

Some adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • White spots or sores in the mouth, throat, or on the lips
  • Fever, chills, a cough, a sore throat, or other symptoms of illness
  • Uncommon bruising or bleeding
  • Bluish gums
  • Nosebleeds
  • Small skin spots that are red or purple
  • Blood in the feces or urine
  • Breathing difficulty
  • Chest ache
  • Rapid or erratic heartbeat
  • Light skin
  • Chilly fingers and feet
  • Severe thirst
  • Sticky, dry mouth
  • Darkened eyes
  • Fewer urinations
  • Feeling unsteady or lightheaded

Other negative effects of pralatrexate injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at or by phone at 1-800-332-1088 if you have a serious side event.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the pralatrexate injection, your doctor will request a few lab tests.

Any queries you may have regarding your medicine, ask your doctor.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Folotyn®
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