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Fluticasone and Vilanterol Oral Inhalation

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Why is this medication prescribed?

Fluticasone and vilanterol are used in combination to treat chronic obstructive pulmonary disease (COPD), which comprises chronic bronchitis and emphysema and causes wheezing, shortness of breath, coughing, and tightness in the chest. Fluticasone belongs to the group of drugs known as steroids. It lessens airway edema, which is how it works. Vilanterol belongs to the group of drugs known as long-acting beta-agonists (LABAs). Breathing becomes simpler as a result of the lungs’ opening and relaxation.

How should this medicine be used?

A special inhaler is needed to inhale the powder formulation of fluticasone and vilanterol by mouth. Typically, it is breathed in once daily. Inhale vilanterol and fluticasone at around the same time each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Use it only as directed by your doctor, neither more nor less often.

When experiencing a sudden attack of asthma or COPD, avoid using fluticasone and vilanterol inhalation. A short-acting (rescue) inhaler will be recommended by your doctor for usage during asthmatic and COPD attacks.

Although fluticasone and vilanterol inhalation do not treat COPD or asthma, they can control their symptoms. Even if you feel good, keep using fluticasone and vilanterol. Without consulting your doctor, do not discontinue taking fluticasone with vilanterol. Your symptoms can come back if you stop using fluticasone and vilanterol inhalation.

Request instruction from your physician, pharmacist, or respiratory therapist before using fluticasone and vilanterol inhalation for the first time. While they are watching you, practice using your inhaler.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using fluticasone and vilanterol,

  • If you have any allergies, including to milk protein, vilanterol, fluticasone (Flonase, Flovent), any other drugs, or any of the ingredients in fluticasone and vilanterol inhalation, let your doctor and pharmacist know right once. For a list of the ingredients, ask your pharmacist or look in the patient information.
  • Inform your doctor if you take any other LABAs, including formoterol (Perforomist, Dulera, Symbicort) and salmeterol (Advair, Serevent). Using fluticasone and vilanterol inhalation together is not advised. Which medications you should take and which ones you should quit taking will be determined by your doctor.
  • Inform your physician and pharmacist about any additional prescription and over-the-counter medicines, vitamins, dietary supplements, and herbal products you are using. Any of the following should be mentioned: the beta-blockers atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal, Innopran); the antifungal medications itraconazole (Onmel, Sporanox), ketoconazole, and voriconazole (Vfend); diuretics (often known as “water pills”), conivaptan (Vaprisol), HIV protease inhibitors as indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase), among others; other COPD drugs include nefazodone, troleandomycin (TAO; no longer available in the US), and telithromycin (Ketek; no longer available in the US). Additionally, let your doctor and pharmacist know if you’ve recently stopped taking any of the following medications: Amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), monoamine oxidase (MAO) inhibitors include isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Protriptyline and trimipramine are also available under the brand names Vivactil and Surmontil. Fluticasone and vilanterol may also interact with many other drugs, so be sure to let your doctor know about all the drugs you’re taking even those not on this list. Your doctor might need to adjust the dosage of your medication or keep a close eye out for any negative effects.
  • Inform your doctor if you or anyone in your family has ever experienced osteoporosis (a condition where the bones become brittle and weak), high blood pressure, irregular heartbeat, seizures, hyperthyroidism (a condition where the body produces too much thyroid hormone), diabetes, tuberculosis (TB), glaucoma (an eye disease), cataracts (clouding of the eyes’ lens), any condition that affects your immune system, heart or liver, and hyperthyroidism. Also let your doctor know if you have pneumonia, herpes eye infection, or any other infection.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while taking fluticasone and vilanterol.
  • Inform the surgeon or dentist that you are taking fluticasone and vilanterol if you are having surgery, including dental surgery.
  • If you have never had chickenpox or measles and have not had a vaccination against these diseases, let your doctor know. Avoid sick people, especially those who have the measles or chickenpox. Call your doctor right once if you are exposed to these infections or if you start to experience their symptoms. To safeguard yourself against certain infections, you might need to receive a vaccine (shot).

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

The missed dose should be taken as soon as you remember. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. Never use more than one dose per day, and never take two doses at once to make up for missing ones.

What side effects can this medication cause?

Fluticasone and vilanterol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • Headache
  • Nervousness
  • Region of your body that you are unable to control shakes
  • Joints hurt
  • Painful throat or a runny nose

Some adverse effects can be very harmful. Call your doctor right away if you suffer any of the following adverse effects, or seek emergency medical attention:

  • Hives
  • Rash
  • Face, throat, or tongue swelling
  • Rapid heartbeat or erratic heartbeat
  • Chest pain
  • Chest tightness, wheezing, or coughing that starts soon after inhaling fluticasone with vilanterol
  • Throat or mouth white patches
  • Fever, chills, or other infection-related symptoms
  • Cough, breathing issues, or a change in the hue of sputum (the mucus you may cough up)

The use of fluticasone with vilanterol may make you more likely to develop cataracts or glaucoma. During your fluticasone and vilanterol treatment, you’ll probably need to have regular eye exams. Inform your doctor if you experience any of the following vision changes: blurred vision, seeing haloes or bright colors around lights; or eye pain, redness, or discomfort. During your fluticasone and vilanterol treatment, you’ll probably need to have regular eye exams and bone tests.

Your risk of developing osteoporosis may increase if you use fluticasone and vilanterol. Discuss the dangers of using this drug with your doctor.

Vilanterol and fluticasone may also have other adverse effects. If you experience any strange issues while taking this drug, call your doctor right away.

What should I know about storage and disposal of this medication?

Keep this medication out of children’s reach and tightly closed in the foil tray it was packaged in. It should not be kept in the bathroom. Store it at room temperature away from sunshine, excessive heat, and moisture. After removing the inhaler from the foil overwrap and after each blister has been used (when the dose indicator displays 0), or six weeks later, whichever comes first, dispose of it.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilizing a medicine take-back program is the best way to get rid of your medication. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back program, see the FDA’s Safe Disposal of Medicines website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Seizures
  • Chest ache
  • Breathing difficulty
  • Dizziness
  • Hammering, rapid, or erratic heartbeat
  • Nervousness
  • Headache
  • Region of your body that you are unable to control shakes
  • Weak or cramping muscles
  • Mouth ache
  • Nausea
  • Extreme fatigue
  • Having trouble falling or staying asleep

What other information should I know?

Keep all of your doctor’s appointments.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Breo Ellipta®
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