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Fludarabine Injection

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WARNING

Fludarabine injection must be administered under the direction of a physician with training in administering chemotherapy drugs for cancer.

Your bone marrow’s capacity to produce blood cells may be reduced as a result of fludarabine injection. Your risk of getting a serious or life-threatening infection may rise as a result of this decline and you might experience risky symptoms. To reduce the possibility that you’ll experience a serious infection while receiving therapy, your doctor can advise additional medications. Inform your doctor if you have or have ever had an immune system disorder, a low quantity of any sort of blood cells, or if you ever got an infection because your blood cell levels were too low. Call your doctor right away if you have any of the following signs or symptoms: Breathlessness, rapid heartbeat, headache, dizziness, pale skin, extreme fatigue, unusual bleeding or bruising, black, tarry, or bloody stool, bloody or coffee-ground-like vomit, as well as fever, chills, cough, sore throat, difficult, painful, or frequent urination, or other infection-related symptoms.

The nervous system may also be damaged by fludarabine injection. Call your doctor right away if you have any of the following symptoms: convulsions, agitation, disorientation, and coma (prolonged loss of consciousness).

A dangerous or even fatal illness where the body fights and kills its own blood cells might result with fludarabine injection. If you have ever experienced this symptom after taking fludarabine in the past, let your doctor know. Call your doctor right away if you have any of the following symptoms: Blood in the urine, dark urine, yellow skin, tiny red or purple spots on the skin, nosebleeds, severe menstrual bleeding, coughing up blood, or trouble breathing because of throat bleeding are all signs of blood loss.

People with chronic lymphocytic leukemia who combined fludarabine injection and pentostatin (Nipent) were at a high risk of suffering serious lung damage, according to a clinical research. This lung damage did, in some circumstances, result in death. As a result, your doctor won’t advise you to take pentostatin (Nipent) and fludarabine injection at the same time.

Keep all of your appointments with your physician and the lab. In order to monitor your body’s reaction to fludarabine injection, your doctor will prescribe a number of tests.

Discuss the dangers of obtaining an injection of fludarabine with your doctor.

Why is this medication prescribed?

Adults with chronic lymphocytic leukemia (CLL; a form of white blood cell malignancy) who have had at least one other treatment but have not improved are treated with fludarabine injection. The drug fludarabine injection belongs to the group of drugs known as purine analogs. It functions by reducing or halting the development of cancer cells within your body.

How should this medicine be used?

A doctor or nurse will administer the fludarabine injection over the course of 30 minutes intravenously (into a vein) in a doctor’s office or hospital outpatient clinic. The drug is available as a powder to be mixed with fluid. Typically, it is injected once every day for five days straight. This time of treatment is known as a cycle, and it may be repeated every 28 days for a number of cycles.

If you encounter certain adverse effects, your doctor may decide to postpone your treatment or change your dose. Tell your doctor how you are feeling throughout your fludarabine injection treatment.

Other uses for this medicine

Non-Hodgkin’s lymphoma (NHL; a cancer that starts in a type of white blood cell that often fights infection) and mycosis fungoides (a type of lymphoma that affects the skin) are two more conditions that are occasionally treated with fludarabine injection. The dangers of using this drug for your illness should be discussed with your doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving fludarabine injection,

  • If you have any allergies, including those to any of the substances in fludarabine injection, notify your doctor and pharmacist right away. Request an ingredient list from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter medications, vitamins, herbal items, nutritional supplements, and any drugs you are now taking or intend to take. Aside from cytarabine (Cytosar-U, DepoCyt), make sure to specify the drug that is indicated in the IMPORTANT WARNING section. Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects.
  • If you have renal illness now or ever have, let your doctor know.Tell your doctor if you have ever undergone radiation therapy, which employs waves of high-energy particles to kill cancer cells, as well as all the other chemotherapy drugs you have been prescribed. Inform your physician that you have received fludarabine treatment before you get chemotherapy or radiation therapy in the future.
  • You should be aware that fludarabine injection may interfere with a woman’s regular menstrual cycle and may prevent sperm from developing in a man. However, you shouldn’t presumptively believe that neither you nor your partner could conceive. Before starting this medicine, you should let your doctor know if you are pregnant or nursing. While having fludarabine injection or for at least six months after therapy, you shouldn’t intend to become a parent. To avoid getting pregnant during this period, choose a trustworthy birth control method. To learn more, consult your doctor. The fetus could suffer from fludarabine injection.
  • Inform the surgeon or dentist that you are receiving fludarabine injection if you are having surgery, including dental surgery.
  • Fludarabine injection may result in drowsiness, weakness, confusion, agitation, seizures, and changes in eyesight. Prior to understanding how this drug affects you, avoid using machinery or driving a car.
  • Before getting any shots during your fludarabine injection treatment, discuss it with your doctor.
  • You should be aware that if you require a blood transfusion while receiving fludarabine injectable treatment or at any point after treatment, you could experience a severe or life-threatening reaction. Before obtaining a blood transfusion, be sure to inform your doctor that you are undergoing or have recently had fludarabine injection.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Fludarabine injectable side effects are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Reduced appetite
  • Nausea
  • Vomiting
  • Constipation
  • Diarrhea
  • Oral sores
  • Hair fall
  • Tingling, discomfort, burning, or numbness in the hands, arms, feet, or legs
  • Joint or muscle ache
  • Headache
  • Depression
  • Issues with sleep

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

  • Chest discomfort or agony
  • Rapid or erratic heartbeat
  • Loss of hearing
  • Aching on the body’s side
  • Edema of the lower legs, lower arms, feet, ankles, or hands
  • Rash
  • Hives
  • Breathing or swallowing challenges
  • Blistered or flaking skin

Other adverse effects from fludarabine injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online at http://www.fda.gov/Safety/MedWatch or by phone at 1-800-332-1088 if you have a serious side event.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Significant bruising or bleeding
  • A fever, chills, cough, sore throat, or other infection-related symptoms
  • Gradual blindness
  • Coma

What other information should I know?

If you have any queries regarding fludarabine injection, consult your physician or pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Fludara®
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